8RB6
| Structure of Aldo-Keto Reductase 1C3 (AKR1C3) in complex with an inhibitor M689, with the 3-hydroxy-benzoisoxazole moiety. Resolution 2.0A | 分子名称: | 1,2-ETHANEDIOL, 4-[[4-(3-hydroxyphenyl)phenyl]amino]-1,2-benzoxazol-3-ol, Aldo-keto reductase family 1 member C3, ... | 著者 | Frydenvang, K, Mirza, O.A. | 登録日 | 2023-12-03 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer. Eur.J.Med.Chem., 268, 2024
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8A7D
| Partial dimer complex of PAPP-A and its inhibitor STC2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Pappalysin-1, ... | 著者 | Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C. | 登録日 | 2022-06-20 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13, 2022
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8A7E
| PAPP-A dimer in complex with its inhibitor STC2 | 分子名称: | CALCIUM ION, Pappalysin-1, Stanniocalcin-2, ... | 著者 | Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C. | 登録日 | 2022-06-20 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (5.02 Å) | 主引用文献 | Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13, 2022
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6RUQ
| Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution | 分子名称: | (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Krintel, C, Venskutonyte, R, Mirza, O.A, Gajhede, M, Kastrup, J.S. | 登録日 | 2019-05-28 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4.65 Å) | 主引用文献 | Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. Febs J., 288, 2021
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5M99
| Functional Characterization and Crystal Structure of Thermostable Amylase from Thermotoga petrophila, reveals High Thermostability and an Archaic form of Dimerization | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-amylase, ... | 著者 | Hameed, U, Price, I, Mirza, O.A. | 登録日 | 2016-11-01 | 公開日 | 2017-07-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization. Biochim. Biophys. Acta, 1865, 2017
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