1ZDY
 
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1ZB6
 | | Co-Crystal Structure of ORF2 an Aromatic Prenyl Transferase from Streptomyces sp. strain cl190 complexed with GSPP and 1,6-dihydroxynaphtalene | | 分子名称: | 1,6-DIHYDROXY NAPHTHALENE, Aromatic prenyltransferase, GERANYL S-THIOLODIPHOSPHATE, ... | | 著者 | Kuzuyama, T, Noel, J.P, Richard, S.B. | | 登録日 | 2005-04-07 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products.
Nature, 435, 2005
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1ZCW
 | | Co-crystal structure of Orf2 an aromatic prenyl transferase from Streptomyces sp. strain CL190 complexed with GPP | | 分子名称: | Aromatic prenyltransferase, GERANYL DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Kuzuyama, T, Noel, J.P, Richard, S.B. | | 登録日 | 2005-04-13 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products.
Nature, 435, 2005
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1ZDW
 | | Co-crystal structure of Orf2 an aromatic prenyl transferase from Streptomyces sp. strain CL190 complexed with GSPP and Flaviolin | | 分子名称: | Aromatic prenyltransferase, FLAVIOLIN, GERANYL S-THIOLODIPHOSPHATE, ... | | 著者 | Kuzuyama, T, Noel, J.P, Richard, S.B. | | 登録日 | 2005-04-15 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products.
Nature, 435, 2005
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7YLZ
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8HAR
 | | SAH-bound C-Methyltransferase Fur6 from Streptomyces sp. KO-3988 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fur6, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Noguchi, T, Nagata, R, Tomita, T, Kuzuyama, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Reductive biosynthesis of meroterpenoids via transient diazotization
To Be Published
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6KTQ
 | | Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA | | 分子名称: | 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ... | | 著者 | Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2019-08-28 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius.
Febs J., 288, 2021
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4Y1P
 | | Crystal structure of 3-isopropylmalate dehydrogenase (Saci_0600) from Sulfolobus acidocaldarius complex with 3-isopropylmalate and Mg2+ | | 分子名称: | 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, MAGNESIUM ION, ... | | 著者 | Takahashi, K, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2015-02-08 | | 公開日 | 2016-03-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Characterization of two beta-decarboxylating dehydrogenases from Sulfolobus acidocaldarius
Extremophiles, 20, 2016
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4YB4
 | | Crystal structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium ion (II) and NADH | | 分子名称: | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Takahashi, K, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2015-02-18 | | 公開日 | 2016-03-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium(II) and NADH
To Be Published
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5X3D
 | | Crystal structure of HEP-CMP-bound form of cytidylyltransferase (CyTase) domain of Fom1 from Streptomyces wedmorensis | | 分子名称: | Phosphoenolpyruvate phosphomutase, [[(2R,3S,4R,5R)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-(2-hydroxyethyl)phosphinic acid | | 著者 | Tomita, T, Cho, S.H, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2017-02-04 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme
ACS Chem. Biol., 12, 2017
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5XOY
 | | Crystal structure of LysK from Thermus thermophilus in complex with Lysine | | 分子名称: | LYSINE, SULFATE ION, [LysW]-lysine hydrolase | | 著者 | Tomita, T, Fujita, S, Hasebe, F, Cho, S.-H, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2017-05-31 | | 公開日 | 2017-09-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Crystal structure of LysK, an enzyme catalyzing the last step of lysine biosynthesis in Thermus thermophilus, in complex with lysine: Insight into the mechanism for recognition of the amino-group carrier protein, LysW
Biochem. Biophys. Res. Commun., 491, 2017
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3D40
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with diphosphate | | 分子名称: | DIPHOSPHATE, FomA protein | | 著者 | Pakhomova, S, Bartlett, S.G, Augustus, A, Kuzuyama, T, Newcomer, M.E. | | 登録日 | 2008-05-13 | | 公開日 | 2008-08-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Crystal Structure of Fosfomycin Resistance Kinase FomA from Streptomyces wedmorensis.
J.Biol.Chem., 283, 2008
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3D41
 | | Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgAMPPNP and fosfomycin | | 分子名称: | FOSFOMYCIN, FomA protein, MAGNESIUM ION, ... | | 著者 | Pakhomova, S, Bartlett, S.G, Augustus, A, Kuzuyama, T, Newcomer, M.E. | | 登録日 | 2008-05-13 | | 公開日 | 2008-08-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of Fosfomycin Resistance Kinase FomA from Streptomyces wedmorensis.
J.Biol.Chem., 283, 2008
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7VWS
 | | Carbazole Prenyl Transferase LvqB4 | | 分子名称: | 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, LvqB4, MAGNESIUM ION, ... | | 著者 | Suemune, H, Nagata, R, Kuzuyama, T, Nagano, S. | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7VWT
 | | Carbazole Prenyl Transferase CqsB4 | | 分子名称: | 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, CqsB4, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Suemune, H, Nagata, R, Kuzuyama, T, Nagano, S. | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes.
Angew.Chem.Int.Ed.Engl., 61, 2022
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1IV4
 | | Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form Substrate) | | 分子名称: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION | | 著者 | Kishida, H, Wada, T, Unzai, S, Kuzuyama, T, Terada, T, Sirouzu, M, Yokoyama, S, Tame, J.R.H, Park, S.-Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2002-03-11 | | 公開日 | 2002-09-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
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1IV1
 | | Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase | | 分子名称: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | | 著者 | Kishida, H, Wada, T, Unzai, S, Kuzuyama, T, Terada, T, Sirouzu, M, Yokoyama, S, Tame, J.R.H, Park, S.-Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2002-03-11 | | 公開日 | 2002-09-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
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1IV3
 | | Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form MG atoms) | | 分子名称: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MAGNESIUM ION | | 著者 | Kishida, H, Wada, T, Unzai, S, Kuzuyama, T, Terada, T, Sirouzu, M, Yokoyama, S, Tame, J.R.H, Park, S.-Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2002-03-11 | | 公開日 | 2002-09-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
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1IV2
 | | Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form CDP) | | 分子名称: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | Kishida, H, Wada, T, Unzai, S, Kuzuyama, T, Terada, T, Sirouzu, M, Yokoyama, S, Tame, J.R.H, Park, S.-Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2002-03-11 | | 公開日 | 2002-09-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
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6IR4
 | | Crystal structure of BioU from Synechocystis sp.PCC6803 (apo form) | | 分子名称: | Slr0355 protein | | 著者 | Sakaki, K, Oishi, K, Shimizu, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2018-11-10 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.
Nat.Chem.Biol., 16, 2020
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6ITD
 | | Crystal structure of BioU (K124A) from Synechocystis sp.PCC6803 in complex with the analog of reaction intermediate, 3-(1-aminoethyl)-nonanedioic acid | | 分子名称: | 3-(1-AMINOETHYL)NONANEDIOIC ACID, Slr0355 protein | | 著者 | Sakaki, K, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2018-11-21 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.
Nat.Chem.Biol., 16, 2020
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5GUK
 | | Crystal structure of apo form of cyclolavandulyl diphosphate synthase (CLDS) from Streptomyces sp. CL190 | | 分子名称: | CHLORIDE ION, Cyclolavandulyl diphosphate synthase | | 著者 | Tomita, T, Kobayashi, M, Nishiyama, M, Kuzuyama, T. | | 登録日 | 2016-08-29 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization.
Angew. Chem. Int. Ed. Engl., 56, 2017
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5GUL
 | | Crystal structure of Tris/PPix2/Mg2+ bound form of cyclolavandulyl diphosphate synthase (CLDS) from Streptomyces sp. CL190 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclolavandulyl diphosphate synthase, MAGNESIUM ION, ... | | 著者 | Tomita, T, Kobayashi, M, Nishiyama, M, Kuzuyama, T. | | 登録日 | 2016-08-29 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization.
Angew. Chem. Int. Ed. Engl., 56, 2017
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5GUE
 | | Crystal structure of CotB2 (GGSPP/Mg2+-Bound Form) from Streptomyces melanosporofaciens | | 分子名称: | Cyclooctat-9-en-7-ol synthase, MAGNESIUM ION, phosphonooxy-[(10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]sulfanyl-phosphinic acid | | 著者 | Tomita, T, Kim, S.-Y, Ozaki, T, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2016-08-28 | | 公開日 | 2017-06-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
ACS Chem. Biol., 12, 2017
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5GUC
 | | Crystal structure of CotB2 (apo form) from Streptomyces melanosporofaciens | | 分子名称: | Cyclooctat-9-en-7-ol synthase, FORMIC ACID | | 著者 | Tomita, T, Kim, S.-Y, Ozaki, T, Yoshida, A, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2016-08-28 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
ACS Chem. Biol., 12, 2017
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