6HMZ
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![BU of 6hmz by Molmil](/molmil-images/mine/6hmz) | Crystal Structure of a Single-Domain Cyclophilin from Brassica napus Phloem Sap | 分子名称: | Cyclosporin, MAGNESIUM ION, MALONATE ION, ... | 著者 | Falke, S, Hanhart, P, Garbe, M, Thiess, M, Betzel, C, Kehr, J. | 登録日 | 2018-09-13 | 公開日 | 2018-11-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus. Sci Rep, 9, 2019
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6YUR
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![BU of 6yur by Molmil](/molmil-images/mine/6yur) | Crystal structure of S. aureus FabI inhibited by SKTS1 | 分子名称: | 6-[4-(4-hexyl-2-oxidanyl-phenoxy)phenoxy]pyridin-2-ol, Enoyl-[acyl-carrier-protein] reductase [NADPH], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Weinrich, J.D, Eltschkner, S, Schiebel, J, Kehrein, J, Le, T.A, Davoodi, S, Merget, B, Tonge, P.J, Engels, B, Sotriffer, C.A, Kisker, C. | 登録日 | 2020-04-27 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure. Acs Infect Dis., 7, 2021
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6YUU
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![BU of 6yuu by Molmil](/molmil-images/mine/6yuu) | Crystal structure of M. tuberculosis InhA inhibited by SKTS1 | 分子名称: | 6-[4-(4-hexyl-2-oxidanyl-phenoxy)phenoxy]pyridin-2-ol, CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | 著者 | Eltschkner, S, Schiebel, J, Kehrein, J, Le, T.A, Davoodi, S, Merget, B, Weinrich, J.D, Tonge, P.J, Engels, B, Sotriffer, C.A, Kisker, C. | 登録日 | 2020-04-27 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure. Acs Infect Dis., 7, 2021
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6EU5
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![BU of 6eu5 by Molmil](/molmil-images/mine/6eu5) | Leishmania major N-myristoyltransferase with bound myristoyl-CoA and inhibitor | 分子名称: | 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA | 著者 | Brenk, R, Kehrein, J, Kersten, C. | 登録日 | 2017-10-27 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.496083 Å) | 主引用文献 | How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 2019
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6EWF
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![BU of 6ewf by Molmil](/molmil-images/mine/6ewf) | |
6F56
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![BU of 6f56 by Molmil](/molmil-images/mine/6f56) | |
7PLK
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![BU of 7plk by Molmil](/molmil-images/mine/7plk) | |
7PUX
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![BU of 7pux by Molmil](/molmil-images/mine/7pux) | |
7O6R
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![BU of 7o6r by Molmil](/molmil-images/mine/7o6r) | |
7ODI
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![BU of 7odi by Molmil](/molmil-images/mine/7odi) | |
7ODB
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![BU of 7odb by Molmil](/molmil-images/mine/7odb) | Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with triazine-derivative | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-methyl-5-sulfanylidene-2H-1,2,4-triazin-3-one, GLYCEROL, ... | 著者 | Zehe, M, Grimm, C, Sotriffer, C. | 登録日 | 2021-04-29 | 公開日 | 2022-06-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.662 Å) | 主引用文献 | Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
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7ODD
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![BU of 7odd by Molmil](/molmil-images/mine/7odd) | |
6H54
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![BU of 6h54 by Molmil](/molmil-images/mine/6h54) | CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, GLYCEROL, ... | 著者 | Plank, C, Zehe, M, Grimm, C, Sotriffer, C. | 登録日 | 2018-07-23 | 公開日 | 2019-08-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
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6FZ3
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![BU of 6fz3 by Molmil](/molmil-images/mine/6fz3) | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | 分子名称: | 2,6-bis(chloranyl)-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | 著者 | Kersten, F.C, Brenk, R. | 登録日 | 2018-03-13 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 63, 2020
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6FZ2
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![BU of 6fz2 by Molmil](/molmil-images/mine/6fz2) | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | 分子名称: | GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, MAGNESIUM ION, ... | 著者 | Kersten, F.C, Brenk, R, Jaenicke, E. | 登録日 | 2018-03-13 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 63, 2020
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6FZ5
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![BU of 6fz5 by Molmil](/molmil-images/mine/6fz5) | Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound | 分子名称: | 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | 著者 | Kersten, F.C, Brenk, R. | 登録日 | 2018-03-14 | 公開日 | 2019-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 63, 2020
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