4Q1N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q1n by Molmil](/molmil-images/mine/4q1n) | Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors | 分子名称: | (3S,4R,5R)-N-cyclopropyl-N'-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-N-[5-(propan-2-yl)pyridin-2-yl]piperidine-3,5-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Schiering, N, D'Arcy, A, Irie, O, Yokokawa, F. | 登録日 | 2014-04-04 | 公開日 | 2014-08-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. ACS Med Chem Lett, 5, 2014
|
|
2R6N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r6n by Molmil](/molmil-images/mine/2r6n) | Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K | 分子名称: | 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine, Cathepsin K | 著者 | Cowan-Jacob, S.W, Ramage, P, Mathis, B, Geisse, S. | 登録日 | 2007-09-06 | 公開日 | 2007-11-06 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Novel scaffold for cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
|
|
4PYV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pyv by Molmil](/molmil-images/mine/4pyv) | Crystal structure of renin in complex with compound4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Renin, ... | 著者 | Ostermann, N, Zink, F. | 登録日 | 2014-03-28 | 公開日 | 2014-10-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. ACS Med Chem Lett, 5, 2014
|
|