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Discovery of DS15060524; Gene targeting chimera (GeneTAC) for the treatment of Friedreich's Ataxia (FRDA)
分子名称:	DNA (5'-D(APAPGPAPAPGPAPAPG)-3'), DNA (5'-D(CPTPTPCPTPTPCPTPT)-3'), ~{N}-[3-[3-(dimethylamino)propylamino]-3-oxidanylidene-propyl]-1-methyl-4-[3-[[1-methyl-4-[[1-methyl-4-[3-[[1-methyl-4-[(1-methylimidazol-2-yl)carbonylamino]pyrrol-2-yl]carbonylamino]propanoylamino]imidazol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]propanoylamino]imidazole-2-carboxamide
著者	Takase, N, Kawai, G, Igarashi, W, Katagiri, T.
登録日	2021-07-28
公開日	2022-08-03
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Discovery of DS15060524; Gene targeting chimera (GeneTAC) for the treatment of Friedreich's Ataxia (FRDA) To be published

Crystal structure of EHMT2 SET domain in complex with compound 5.
分子名称:	Histone-lysine N-methyltransferase EHMT2, N~2~-{4-methoxy-3-[3-(pyrrolidin-1-yl)propoxy]phenyl}-N~4~,6-dimethylpyrimidine-2,4-diamine, S-ADENOSYLMETHIONINE, ...
著者	Suzuki, M, Mizuno, T, Katayama, K.
登録日	2020-04-03
公開日	2020-11-11
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. Bioorg.Med.Chem.Lett., 30, 2020

Crystal structure of EHMT2 SET domain in complex with compound 13
分子名称:	Histone-lysine N-methyltransferase EHMT2, N2-[4-methoxy-3-(2,3,4,7-tetrahydro-1H-azepin-5-yl)phenyl]-N4,6-dimethyl-pyrimidine-2,4-diamine, S-ADENOSYLMETHIONINE, ...
著者	Suzuki, M, Mizuno, M, Katayama, K.
登録日	2020-04-06
公開日	2020-11-11
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. Bioorg.Med.Chem.Lett., 30, 2020