2Y4W
 
 | | Solution structure of human ubiquitin conjugating enzyme Rad6b | | 分子名称: | UBIQUITIN-CONJUGATING ENZYME E2 B | | 著者 | Huang, A, Hibbert, R.G, deJong, R.N, Das, D, Sixma, T.K, Boelens, R. | | 登録日 | 2011-01-11 | | 公開日 | 2011-05-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Symmetry and Asymmetry of the Ring-Ring Dimer of Rad18
J.Mol.Biol., 410, 2011
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2K4D
 | | E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity | | 分子名称: | E3 ubiquitin-protein ligase CBL, ZINC ION | | 著者 | Huang, A, De Jong, R.N, Wienk, H, Winkler, S.G, Timmers, H.T.M, Boelens, R. | | 登録日 | 2008-06-06 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity
J.Mol.Biol., 385, 2009
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2PJT
 | | Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344 | | 分子名称: | CALCIUM ION, Collagenase 3, TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE, ... | | 著者 | Xu, Z, Huang, A, Lovering, F, Levin, J.I, Mosyak, L. | | 登録日 | 2007-04-16 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Bioorg.Med.Chem., 15, 2007
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3C8O
 | | The Crystal Structure of RraA from PAO1 | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Regulator of ribonuclease activity A, ... | | 著者 | Luo, M, Niu, S, Yin, Y, Huang, A, Wang, D. | | 登録日 | 2008-02-12 | | 公開日 | 2009-02-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Crystal Structure of RraA from PAO1
To be published
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2LH8
 | | Syrian hamster prion protein with thiamine | | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Major prion protein | | 著者 | Perez-Pineiro, R, Bjorndahl, T.C, Berjanskii, M, Hau, D, Li, L, Huang, A, Lee, R, Gibbs, E, Ladner, C, Wei Dong, Y, Abera, A, Cashman, N.R, Wishart, D. | | 登録日 | 2011-08-05 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The prion protein binds thiamine.
Febs J., 278, 2011
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2Y43
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1T2M
 | | Solution Structure Of The Pdz Domain Of AF-6 | | 分子名称: | AF-6 protein | | 著者 | Zhou, H, Wu, J.H, Xu, Y.Q, Huang, A.D, Shi, Y.Y. | | 登録日 | 2004-04-22 | | 公開日 | 2005-02-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of AF-6 PDZ Domain and Its Interaction with the C-terminal Peptides from Neurexin and Bcr
J.Biol.Chem., 280, 2005
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5KSJ
 | | Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | | 著者 | Ahmed, M.H, Safo, M.K, Xia, Y. | | 登録日 | 2016-07-08 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sci Rep, 7, 2017
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8IEM
 | | Cryo-EM structure of ATP13A2 in the E2P state | | 分子名称: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IES
 | | Cryo-EM structure of ATP13A2 in the E1P-ADP state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEN
 | | Cryo-EM structure of ATP13A2 in the E2-Pi state | | 分子名称: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IER
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8IEO
 | | Cryo-EM structure of ATP13A2 in the nominal E1P state | | 分子名称: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | | 著者 | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | 登録日 | 2023-02-15 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEL
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8IEK
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5KSI
 | | Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate | | 分子名称: | (2R)-2,3-diphosphoglyceric acid, (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, ... | | 著者 | Ahmed, M.H, Safo, M.K, Xia, Y. | | 登録日 | 2016-07-08 | | 公開日 | 2017-07-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sci Rep, 7, 2017
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8VEU
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8VET
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8VEX
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8VEY
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8VEW
 | | Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24 | | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5-{2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl](oxo)acetamido}pyridine-3-carboxamide, CHLORIDE ION, ... | | 著者 | Whittington, D.A. | | 登録日 | 2023-12-20 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.
J.Med.Chem., 67, 2024
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8VEO
 | | Crystal structure of PRMT5:MEP50 in complex with MTA | | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Whittington, D.A. | | 登録日 | 2023-12-20 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.
J.Med.Chem., 67, 2024
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2YB6
 | | Native human Rad6 | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, UBIQUITIN-CONJUGATING ENZYME E2 B | | 著者 | Hibbert, R.G, Sixma, T.K. | | 登録日 | 2011-03-02 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | E3 Ligase Rad18 Promotes Monoubiquitination Rather Than Ubiquitin Chain Formation by E2 Enzyme Rad6.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2YBF
 | | Complex of Rad18 (Rad6 binding domain) with Rad6b | | 分子名称: | BETA-MERCAPTOETHANOL, E3 UBIQUITIN-PROTEIN LIGASE RAD18, SODIUM ION, ... | | 著者 | Hibbert, R.G, Sixma, T.K. | | 登録日 | 2011-03-08 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | E3 Ligase Rad18 Promotes Monoubiquitination Rather Than Ubiquitin Chain Formation by E2 Enzyme Rad6.
Proc.Natl.Acad.Sci.USA, 108, 2011
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8VJB
 | | Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | | 登録日 | 2024-01-06 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
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