2W6R
| Crystal structure of an artificial (ba)8-barrel protein designed from identical half barrels | 分子名称: | IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF | 著者 | Hocker, B, Lochner, A, Seitz, T, Claren, J, Sterner, R. | 登録日 | 2008-12-18 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | High-Resolution Crystal Structure of an Artificial (Betaalpha)(8)-Barrel Protein Designed from Identical Half-Barrels. Biochemistry, 48, 2009
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4Q37
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5OWF
| Structure of a LAO-binding protein mutant with glutamine | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLUTAMINE, ... | 著者 | Shanmugaratnam, S, Banda-Vazquez, J, Sosa-Peinado, A, Hocker, B. | 登録日 | 2017-08-31 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Redesign of LAOBP to bind novel l-amino acid ligands. Protein Sci., 27, 2018
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8ASZ
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8AT0
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6EJW
| Tryptophan Repressor TrpR from E.coli wildtype with Indole-3-acetic acid as ligand | 分子名称: | 1H-INDOL-3-YLACETIC ACID, Trp operon repressor | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-09-23 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
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6ELB
| Tryptophan Repressor TrpR from E.coli variant M42F T44L T81M N87G S88Y with Indole-3-acetic acid as ligand | 分子名称: | 1H-INDOL-3-YLACETIC ACID, Trp operon repressor | 著者 | Stiel, A.C, Shanmugaratnam, S, Herud-Sikimic, O, Juergens, G, Hocker, B. | 登録日 | 2017-09-28 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.437 Å) | 主引用文献 | A biosensor for the direct visualization of auxin Nature, 2021
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3CWO
| A beta/alpha-barrel built by the combination of fragments from different folds | 分子名称: | SULFATE ION, beta/alpha-barrel protein based on 1THF and 1TMY | 著者 | Bharat, T.A.M, Eisenbeis, S, Zeth, K, Hocker, B. | 登録日 | 2008-04-22 | 公開日 | 2008-07-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A beta alpha-barrel built by the combination of fragments from different folds. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5BVL
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6Z2I
| Crystal structure of DeNovoTIM6, a de novo designed TIM barrel | 分子名称: | de novo designed TIM barrel DeNovoTIM6 | 著者 | Romero-Romero, S, Kordes, S, Shanmugaratnam, S, Rodriguez-Romero, A, Fernandez-Velasco, D.A, Hocker, B. | 登録日 | 2020-05-15 | 公開日 | 2021-07-21 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | 主引用文献 | The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach. J.Mol.Biol., 433, 2021
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7PU4
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7A8S
| de novo designed ba8-barrel sTIM11 with an alpha-helical extension | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, sTIM11_h3 | 著者 | Shanmugaratnam, S, Wiese, J.G, Hocker, B. | 登録日 | 2020-08-31 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Extension of a de novo TIM barrel with a rationally designed secondary structure element. Protein Sci., 30, 2021
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7QSQ
| Permutated N-terminal lobe of the ribose binding protein from Thermotoga maritima | 分子名称: | 1,2-ETHANEDIOL, Ribose ABC transporter, periplasmic ribose-binding protein, ... | 著者 | Shanmugaratnam, S, Michel, F, Hocker, B. | 登録日 | 2022-01-14 | 公開日 | 2023-01-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structures of permuted halves of a modern ribose-binding protein. Acta Crystallogr D Struct Biol, 79, 2023
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7QSP
| Permutated C-terminal lobe of the ribose binding protein from Thermotoga maritima | 分子名称: | 1,2-ETHANEDIOL, Ribose ABC transporter, periplasmic ribose-binding protein | 著者 | Shanmugaratnam, S, Michel, F, Hocker, B. | 登録日 | 2022-01-14 | 公開日 | 2023-01-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Structures of permuted halves of a modern ribose-binding protein. Acta Crystallogr D Struct Biol, 79, 2023
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8R8N
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8R8O
| Hallucinated de novo TIM barrel with three helical extensions - HalluTIM3-1 | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Beck, J, Shanmugaratnam, S, Hocker, B. | 登録日 | 2023-11-29 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Diversifying de novo TIM barrels by hallucination. Protein Sci., 33, 2024
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8Q52
| A PBP-like protein built from fragments of different folds | 分子名称: | Leucine-specific-binding protein,Chemotaxis protein CheY, SULFATE ION | 著者 | Shanmugaratnam, S, Toledo-Patino, S, Goetz, S.K, Farias-Rico, J.A, Hocker, B. | 登録日 | 2023-08-08 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Molecular handcraft of a well-folded protein chimera. Febs Lett., 2024
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2WRZ
| Crystal structure of an arabinose binding protein with designed serotonin binding site in open, ligand-free state | 分子名称: | L-ARABINOSE-BINDING PERIPLASMIC PROTEIN | 著者 | Schreier, B, Stumpp, C, Wiesner, S, Hocker, B. | 登録日 | 2009-09-03 | 公開日 | 2009-10-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Computational Design of Ligand Binding is not a Solved Problem Proc.Natl.Acad.Sci.USA, 106, 2009
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4J5N
| Crystal Structure of a Deinococcus radiodurans PTE-like lactonase (drPLL) mutant Y28L/D71N/E101G/E179D/V235L/L270M | 分子名称: | COBALT (II) ION, Phosphotriesterase, putative | 著者 | Meier, M.M, Rajendran, C, Malisi, C, Fox, N.G, Xu, C, Schlee, S, Barondeau, D.P, Hocker, B, Sterner, R, Raushel, F.M. | 登録日 | 2013-02-08 | 公開日 | 2013-07-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template. J.Am.Chem.Soc., 135, 2013
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2W79
| Establishing wild-type levels of catalytic activity on natural and artificial (ba)8-barrel protein scaffolds | 分子名称: | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, CHLORIDE ION | 著者 | Claren, J, Malisi, C, Hocker, B, Sterner, R. | 登録日 | 2008-12-21 | 公開日 | 2009-02-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Establishing Wild-Type Levels of Catalytic Activity on Natural and Artificial (Beta Alpha)8- Barrel Protein Scaffolds. Proc.Natl.Acad.Sci.USA, 106, 2009
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6YED
| E.coli's Putrescine receptor PotF in its open apo state | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Shanmugaratnam, S, Kroeger, P, Hocker, B. | 登録日 | 2020-03-24 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF. Structure, 29, 2021
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6YE6
| E.coli's Putrescine receptor PotF complexed with Agmatine | 分子名称: | (2R)-1-methoxypropan-2-amine, (2~{R})-1-[(2~{R})-1-(2-methoxyethoxy)propan-2-yl]oxypropan-2-amine, (2~{S})-1-(2-methoxyethoxy)propan-2-amine, ... | 著者 | Shanmugaratnam, S, Kroeger, P, Hocker, B. | 登録日 | 2020-03-24 | 公開日 | 2021-01-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF. Structure, 29, 2021
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6YE8
| E.coli's Putrescine receptor PotF complexed with Spermidine | 分子名称: | (2R)-1-methoxypropan-2-amine, (2~{S})-1-(2-methoxyethoxy)propan-2-amine, CHLORIDE ION, ... | 著者 | Shanmugaratnam, S, Kroeger, P, Hocker, B. | 登録日 | 2020-03-24 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF. Structure, 29, 2021
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6YEB
| E.coli's Putrescine receptor PotF in its closed apo state | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Shanmugaratnam, S, Kroeger, P, Hocker, B. | 登録日 | 2020-03-24 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF. Structure, 29, 2021
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6YE7
| E.coli's Putrescine receptor PotF complexed with Cadaverine | 分子名称: | 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CHLORIDE ION, ... | 著者 | Shanmugaratnam, S, Kroeger, P, Hocker, B. | 登録日 | 2020-03-24 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF. Structure, 29, 2021
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