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An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
分子名称:	(1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside, DNA (5'-D(GPCPTPAPTPAPGPC)-3')
著者	Woo, C.M, Li, Z, Paulson, E, Herzon, S.B.
登録日	2015-11-07
公開日	2016-06-01
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A. Proc.Natl.Acad.Sci.USA, 113, 2016

Crystal structure of a self resistance protein ClbS from colibactin biosynthetic gene cluster
分子名称:	Colibactin self-protection protein ClbS
著者	Tripathi, P, Bruner, S.D.
登録日	2017-08-14
公開日	2018-06-27
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.098 Å)
主引用文献	ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance. J. Am. Chem. Soc., 139, 2017

Crystal structure of ClbQ from the colibactin NRPS/PKS pathway
分子名称:	BETA-MERCAPTOETHANOL, Putative thioesterase
著者	Guntaka, N.S, Bruner, S.D.
登録日	2017-01-10
公開日	2017-09-20
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.983 Å)
主引用文献	Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. ACS Chem. Biol., 12, 2017