Search by PDB author

Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, ...
著者	Adams, R, Griffin, R, Doyle, C, Ettorre, A.
登録日	2016-01-25
公開日	2017-01-25
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep, 7, 2017

2M2D

Human programmed cell death 1 receptor
分子名称:	Programmed cell death protein 1
著者	Veverka, V, Cheng, X, Waters, L.C, Muskett, F.W, Morgan, S, Lesley, A, Griffiths, M, Stubberfield, C, Griffin, R, Henry, A.J, Robinson, M.K, Jansson, A, Ladbury, J.E, Ikemizu, S, Davis, S.J, Carr, M.D.
登録日	2012-12-18
公開日	2013-02-27
最終更新日	2013-05-15
実験手法	SOLUTION NMR
主引用文献	Structure and interactions of the human programmed cell death 1 receptor. J.Biol.Chem., 288, 2013

4CFN

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
分子名称:	2,3-DIHYDROXY-1,4-DITHIOBUTANE, 6-(cyclohexylmethoxy)-8-(trifluoromethyl)-9H-purin-2-amine, CYCLIN-A2, ...
著者	Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R.
登録日	2013-11-19
公開日	2013-12-18
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

7KW1

Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-3
分子名称:	(2R,5R,7R,8R,10R,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)oxy]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者	Skene, R.
登録日	2020-11-29
公開日	2021-06-02
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021

7KVX

Structure of hSTING in complex with novel carbocyclic pyrimidine CDN 1
分子名称:	(2R,5R,7R,8R,10R,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)amino]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者	Skene, R.
登録日	2020-11-29
公開日	2021-06-02
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.48 Å)
主引用文献	Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021

7KVZ

Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-2
分子名称:	(2R,5R,7R,8R,10S,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,10,16-trihydroxy-14-[(pyrimidin-4-yl)oxy]decahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者	Skene, R.J.
登録日	2020-11-29
公開日	2022-02-09
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021

8CTO

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in d6-DMSO with cis/trans switching (B-CT conformation)
分子名称:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-05-16
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBF

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in 50% d6-DMSO and 50% water with cis/trans switching (CC conformation, 50%)
分子名称:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBD

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in d6-DMSO with cis/trans switching (A-CC conformation)
分子名称:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBI

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in CDCl3 with cis/trans switching (TT conformation, 47%)
分子名称:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UZL

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in CDCl3 with cis/trans switching (B-TC conformation)
分子名称:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-05-09
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBC

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in d6-DMSO with cis/trans switching
分子名称:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
著者	Ramelot, T.A, Tejero, R, Monteltione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBE

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in d6-DMSO with cis/trans switching
分子名称:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBG

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in CDCl3 with cis/trans switching (A-TT conformation)
分子名称:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBH

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in CDCl3 with cis/trans switching
分子名称:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-03-14
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

8CUN

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in 50% d6-DMSO and 50% water with cis/trans switching (CC conformation, 50%)
分子名称:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-05-17
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

8CWA

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in CDCl3 with cis/trans switching (TC conformation, 53%)
分子名称:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
著者	Ramelot, T.A, Tejero, R, Montelione, G.T.
登録日	2022-05-18
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	SOLUTION NMR
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UCP

computationally designed macrocycle
分子名称:	computationally designed cyclic peptide D8.3.p2
著者	Bhardwaj, G, Baker, D, Rettie, S, Glynn, C, Sawaya, M.
登録日	2022-03-17
公開日	2022-09-14
最終更新日	2022-09-28
実験手法	X-RAY DIFFRACTION (0.85 Å)
主引用文献	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7L7H

Alpha-synuclein fibrils
分子名称:	Alpha-synuclein
著者	Hojjatian, A, Dasari, A.
登録日	2020-12-28
公開日	2022-01-12
最終更新日	2024-05-29
実験手法	ELECTRON MICROSCOPY (4 Å)
主引用文献	Distinct cryo-EM Structure of Alpha-synuclein Filaments derived by Tau To Be Published

4CFX

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
分子名称:	3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]benzenesulfonamide, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2
著者	Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R.
登録日	2013-11-19
公開日	2014-12-10
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

4CFV

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
分子名称:	3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylphenol, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
著者	Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R.
登録日	2013-11-19
公開日	2014-12-10
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

4CFM

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
分子名称:	6-(cyclohexylmethoxy)-8-(2-methylphenyl)-9H-purin-2-amine, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2
著者	Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R.
登録日	2013-11-18
公開日	2014-12-10
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.85 Å)
主引用文献	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

4CFU

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
分子名称:	3-[2-azanyl-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methyl-benzoic acid, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
著者	Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R.
登録日	2013-11-19
公開日	2014-12-10
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

4CFW

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
分子名称:	3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylbenzenesulfonamide, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2
著者	Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R.
登録日	2013-11-19
公開日	2013-12-18
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.45 Å)
主引用文献	8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

6C99

Crystal structure of FcRn bound to UCB-303
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, CITRIC ACID, ...
著者	Fox III, D, Abendroth, J, Porter, J, Deboves, H.
登録日	2018-01-25
公開日	2018-05-30
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biol., 16, 2018

12 >

全ヒット件数:	28
表示件数:	25
表示順	関連性が高い順