1GZE
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![BU of 1gze by Molmil](/molmil-images/mine/1gze) | Structure of the Clostridium botulinum C3 exoenzyme (L177C mutant) | 分子名称: | MERCURY (II) ION, MONO-ADP-RIBOSYLTRANSFERASE C3 | 著者 | Menetrey, J, Flatau, G, Stura, E.A, Charbonnier, J.B, Gas, F, Teulon, J.M, Le Du, M.H, Boquet, P, Menez, A. | 登録日 | 2002-05-21 | 公開日 | 2002-08-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Nad Binding Induces Conformational Changes in Rho Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme J.Biol.Chem., 277, 2002
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1GZF
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![BU of 1gzf by Molmil](/molmil-images/mine/1gzf) | Structure of the Clostridium botulinum C3 exoenzyme (wild-type) in complex with NAD | 分子名称: | 3-(AMINOCARBONYL)-1-[(3R,4S,5R)-3,4-DIHYDROXY-5-METHYLTETRAHYDRO-2-FURANYL]PYRIDINIUM, ADENOSINE-5'-DIPHOSPHATE, MONO-ADP-RIBOSYLTRANSFERASE C3, ... | 著者 | Menetrey, J, Flatau, G, Stura, E.A, Charbonnier, J.B, Gas, F, Teulon, J.M, Le Du, M.H, Boquet, P, Menez, A. | 登録日 | 2002-05-21 | 公開日 | 2002-08-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Nad Binding Induces Conformational Changes in Rho Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme J.Biol.Chem., 277, 2002
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4UYN
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![BU of 4uyn by Molmil](/molmil-images/mine/4uyn) | SAR156497 an exquisitely selective inhibitor of Aurora kinases | 分子名称: | AURORA KINASE A, ethyl (9S)-9-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]-8-hydroxy-5,6,7,9-tetrahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate | 著者 | Carry, J.C, Clerc, F, Minoux, H, Schio, L, Mauger, J, Nair, A, Parmantier, E, Lemoigne, R, Delorme, C, Nicolas, J.P, Krick, A, Abecassis, P.Y, Crocq-Stuerga, V, Pouzieux, S, Delarbre, L, Maignan, S, Bertrand, T, Bjergarde, K, Ma, N, Lachaud, S, Guizani, H, Lebel, R, Doerflinger, G, Monget, S, Perron, S, Gasse, F, Angouillant-Boniface, O, Filoche-Romme, B, Murer, M, Gontier, S, Prevost, C, Monteiro, M.L, Combeau, C. | 登録日 | 2014-09-02 | 公開日 | 2014-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Sar156497, an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58, 2015
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4CQE
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![BU of 4cqe by Molmil](/molmil-images/mine/4cqe) | B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor | 分子名称: | N-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide, SLC45A3-BRAF FUSION PROTEIN | 著者 | Casale, E, Fasolini, M, Pulici, M, Traquandi, G, Marchionni, C, Modugno, M, Lupi, R, Amboldi, N, Colombo, N, Corti, L, Gasparri, F, Pastori, W, Scolaro, A, Donati, D, Felder, E, Galvani, A, Isacchi, A, Pesenti, E, Ciomei, M. | 登録日 | 2014-02-14 | 公開日 | 2014-12-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Optimization of Diarylthiazole B-Raf Inhibitors: Identification of a Compound Endowed with High Oral Antitumor Activity, Mitigated Herg Inhibition, and Low Paradoxical Effect. Chemmedchem, 10, 2015
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4O2P
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![BU of 4o2p by Molmil](/molmil-images/mine/4o2p) | Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine | 分子名称: | 1-[(2R)-2-chloro-2-phenylethyl]-6-{[2-(morpholin-4-yl)ethyl]sulfanyl}-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src | 著者 | Richters, A, Rauh, D. | 登録日 | 2013-12-17 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. J.Med.Chem., 58, 2015
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2C8C
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![BU of 2c8c by Molmil](/molmil-images/mine/2c8c) | Structure of the ARTT motif Q212A mutant C3bot1 Exoenzyme (NAD-bound state, crystal form I) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MONO-ADP-RIBOSYLTRANSFERASE C3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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2C8G
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![BU of 2c8g by Molmil](/molmil-images/mine/2c8g) | Structure of the PN loop Q182A mutant C3bot1 Exoenzyme (Free state, crystal form I) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Properties of Wild-Type and Two Artt Motif Mutants Clostridium Botulinum C3 Exoenzyme Isoform 1 in Different Substrate Complexed States and Crystal Forms. To be Published
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2C8B
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![BU of 2c8b by Molmil](/molmil-images/mine/2c8b) | Structure of the ARTT motif Q212A mutant C3bot1 Exoenzyme (Free state, crystal form II) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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2C8F
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![BU of 2c8f by Molmil](/molmil-images/mine/2c8f) | Structure of the ARTT motif E214N mutant C3bot1 Exoenzyme (NAD-bound state, crystal form III) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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2C8A
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![BU of 2c8a by Molmil](/molmil-images/mine/2c8a) | Structure of the wild-type C3bot1 Exoenzyme (Nicotinamide-bound state, crystal form I) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, NICOTINAMIDE, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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2C89
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![BU of 2c89 by Molmil](/molmil-images/mine/2c89) | Structure of the wild-type C3bot1 Exoenzyme (Free state, crystal form I) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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2C8H
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![BU of 2c8h by Molmil](/molmil-images/mine/2c8h) | Structure of the PN loop Q182A mutant C3bot1 Exoenzyme (NAD-bound state, crystal form I) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Properties of Wild-Type and Two Artt Motif Mutants Clostridium Botulinum C3 Exoenzyme Isoform 1 in Different Substrate Complexed States and Crystal Forms. To be Published
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2C8D
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![BU of 2c8d by Molmil](/molmil-images/mine/2c8d) | Structure of the ARTT motif Q212A mutant C3bot1 Exoenzyme (Free state, crystal form I) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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2C8E
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![BU of 2c8e by Molmil](/molmil-images/mine/2c8e) | Structure of the ARTT motif E214N mutant C3bot1 Exoenzyme (Free state, crystal form III) | 分子名称: | MONO-ADP-RIBOSYLTRANSFERASE C3, SULFATE ION | 著者 | Stura, E.A, Menetrey, J, Flatau, G, Boquet, P, Menez, A. | 登録日 | 2005-12-03 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Basis for the Nad-Hydrolysis Mechanism and the Artt-Loop Plasticity of C3 Exoenzymes. Protein Sci., 17, 2008
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7NP4
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![BU of 7np4 by Molmil](/molmil-images/mine/7np4) | cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Giese, H, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | 登録日 | 2021-02-26 | 公開日 | 2021-08-11 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021
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7NP3
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![BU of 7np3 by Molmil](/molmil-images/mine/7np3) | cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Giese, H.M, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | 登録日 | 2021-02-26 | 公開日 | 2021-08-11 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021
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7NMN
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![BU of 7nmn by Molmil](/molmil-images/mine/7nmn) | Rabbit HCN4 stabilised in amphipol A8-35 | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Rabbit HCN4 | 著者 | Chaves-Sanjuan, A. | 登録日 | 2021-02-23 | 公開日 | 2021-06-30 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021
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4UZD
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![BU of 4uzd by Molmil](/molmil-images/mine/4uzd) | SAR156497 an exquisitely selective inhibitor of Aurora kinases | 分子名称: | AURORA KINASE A, ethyl (9S)-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate | 著者 | Pouzieux, S, Delarbre, L, Crenne, J.Y. | 登録日 | 2014-09-05 | 公開日 | 2014-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58, 2015
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4UZH
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![BU of 4uzh by Molmil](/molmil-images/mine/4uzh) | SAR156497 an exquisitely selective inhibitor of Aurora kinases | 分子名称: | (4S)-4-(2-fluorophenyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b][1,7]naphthyridin-5-one, AURORA 2 KINASE DOMAIN | 著者 | Pouzieux, S, Maignan, S, Crenne, J.Y. | 登録日 | 2014-09-05 | 公開日 | 2014-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58, 2015
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3AWX
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![BU of 3awx by Molmil](/molmil-images/mine/3awx) | |
3AWT
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![BU of 3awt by Molmil](/molmil-images/mine/3awt) | |
3AWY
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![BU of 3awy by Molmil](/molmil-images/mine/3awy) | |
3AWW
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![BU of 3aww by Molmil](/molmil-images/mine/3aww) | |
3AWV
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![BU of 3awv by Molmil](/molmil-images/mine/3awv) | |
3AWS
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![BU of 3aws by Molmil](/molmil-images/mine/3aws) | |