3K0M
 
 | | Cryogenic structure of CypA | | 分子名称: | Cyclophilin A | | 著者 | Fraser, J.S, Alber, T. | | 登録日 | 2009-09-24 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Hidden alternative structures of proline isomerase essential for catalysis.
Nature, 462, 2009
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3K0R
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3K0P
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3K0N
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3K0Q
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3K0O
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3TGP
 | | Room temperature H-ras | | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Fraser, J.S, Alber, T. | | 登録日 | 2011-08-17 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.3075 Å) | | 主引用文献 | Accessing protein conformational ensembles using room-temperature X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2NT3
 | | Receiver domain from Myxococcus xanthus social motility protein FrzS (Y102A Mutant) | | 分子名称: | Response regulator homolog | | 著者 | Fraser, J.S, Echols, N, Merlie, J.P, Zusman, D.R, Alber, T. | | 登録日 | 2006-11-06 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.
Mol.Microbiol., 65, 2007
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5WC7
 | | CypA Mutant - I97V S99T C115S | | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | | 著者 | Fraser, J.S. | | 登録日 | 2017-06-29 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Rescue of conformational dynamics in enzyme catalysis by directed evolution.
Nat Commun, 9, 2018
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5F66
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6BTA
 | | CypA Mutant - S99T C115S | | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | | 著者 | Fraser, J.S, Kenner, L.R, Liu, L. | | 登録日 | 2017-12-06 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Rescue of conformational dynamics in enzyme catalysis by directed evolution.
Nat Commun, 9, 2018
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7RGR
 | | Lysozyme 056 from Deep neural language modeling | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Artificial protein L056, CHLORIDE ION | | 著者 | Fraser, J.S, Holton, J.M, Olmos Jr, J.L, Greene, E.R. | | 登録日 | 2021-07-15 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Large language models generate functional protein sequences across diverse families.
Nat.Biotechnol., 2023
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4OBV
 | | Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT) | | 分子名称: | Pyridoxal-dependent decarboxylase domain protein, alpha-(fluoromethyl)-D-tryptophan, {5-hydroxy-4-[(1E)-4-(1H-indol-3-yl)-3-oxobut-1-en-1-yl]-6-methylpyridin-3-yl}methyl dihydrogen phosphate | | 著者 | Fraser, J.S, Van Benschoten, A.H. | | 登録日 | 2014-01-07 | | 公開日 | 2014-10-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
Cell Host Microbe, 16, 2014
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6DML
 | | A multiconformer ligand model of 3,5 dimethylisoxaxole bound to the bromodomain of human BRD4 | | 分子名称: | 1,2-ETHANEDIOL, 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid, Bromodomain-containing protein 4 | | 著者 | Hudson, B.M, van Zundert, G, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H. | | 登録日 | 2018-06-05 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
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8SPL
 | | Proteinase K Multiconformer Model at 343K | | 分子名称: | ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... | | 著者 | Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. | | 登録日 | 2023-05-03 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.
Methods Enzymol., 688, 2023
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8SOV
 | | Proteinase K Multiconformer Model at 353K | | 分子名称: | ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... | | 著者 | Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. | | 登録日 | 2023-04-30 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.291 Å) | | 主引用文献 | Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.
Methods Enzymol., 688, 2023
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8SOU
 | | Proteinase K Multiconformer Model at 363K | | 分子名称: | ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... | | 著者 | Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. | | 登録日 | 2023-04-30 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.
Methods Enzymol., 688, 2023
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8SQV
 | | Proteinase K Multiconformer Model at 333K | | 分子名称: | CALCIUM ION, Proteinase K, SULFATE ION | | 著者 | Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. | | 登録日 | 2023-05-04 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.
Methods Enzymol., 688, 2023
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8SOG
 | | Proteinase K Multiconformer Model at 313K | | 分子名称: | CALCIUM ION, Proteinase K, SULFATE ION | | 著者 | Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. | | 登録日 | 2023-04-28 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.
Methods Enzymol., 688, 2023
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8SH8
 | | Crystal structure of SARS-CoV-2 NSP3 macrodomain Asn40Asp mutant in complex with ADP-ribose (P43 crystal form) | | 分子名称: | Papain-like protease nsp3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | 著者 | Correy, G.J, Fraser, J.S. | | 登録日 | 2023-04-13 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | | 主引用文献 | Crystal structure of SARS-CoV-2 NSP3 macrodomain Asn40Asp mutant in complex with ADP-ribose (P43 crystal form)
To Be Published
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8SH6
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8FG7
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8FG5
 | | Apo mouse acidic mammalian chitinase, catalytic domain at 100 K | | 分子名称: | Acidic mammalian chitinase, MAGNESIUM ION | | 著者 | Diaz, R.E, Correy, G.J, Young, I.D, Thompson, M.C, Fraser, J.S. | | 登録日 | 2022-12-12 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
Biorxiv, 2024
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8FRA
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8FRC
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