1XCM
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1ZW6
| Crystal Structure of the GTP-bound form of RasQ61G | 分子名称: | CALCIUM ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Ford, B, Hornak, V, Kleinman, H, Nassar, N. | 登録日 | 2005-06-03 | 公開日 | 2006-03-14 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of a transient intermediate for GTP hydrolysis by ras. Structure, 14, 2006
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1ZVQ
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2KT6
| Structural homology between the C-terminal domain of the PapC usher and its plug | 分子名称: | Outer membrane usher protein papC | 著者 | Ford, B, Rego, A, Ragan, T.J, Pinkner, J, Dodson, K, Driscoll, P.C, Hultgren, S, Waksman, G. | 登録日 | 2010-01-19 | 公開日 | 2010-04-21 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Homology between the C-Terminal Domain of the PapC Usher and Its Plug. J.Bacteriol., 192, 2010
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2H0Q
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4XX5
| Structure of PI3K gamma in complex with an inhibitor | 分子名称: | N-[5-(5-methoxypyridin-3-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Collier, P.N, Messersmith, D, Le Tiran, A, Bandarage, U.K, Boucher, C, Come, J, Cottrell, K.M, Damagnez, V, Doran, J.D, Griffith, J.P, Khare-Pandit, S, Krueger, E.B, Ledeboer, M.W, Ledford, B, Liao, Y, Mahajan, S, Moody, C.S, Wang, T, Xu, J, Aronov, A.M. | 登録日 | 2015-01-29 | 公開日 | 2015-08-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structure of PI3K gamma in complex with an inhibitor To Be Published
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4XZ4
| Structure of PI3K gamma in complex with an inhibitor | 分子名称: | N-[5-(6-methoxypyrazin-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Collier, P.N, Messersmith, D, Le Tiran, A, Bandarage, U.K, Boucher, C, Come, J, Cottrell, K.M, Damagnez, V, Doran, J.D, Griffith, J.P, Khare-Pandit, S, Krueger, E.B, Ledeboer, M.W, Ledford, B, Liao, Y, Mahajan, S, Moody, C.S, Wang, T, Xu, J, Aronov, A.M. | 登録日 | 2015-02-03 | 公開日 | 2016-02-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of PI3K gamma in complex with an inhibitor To Be Published
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3L48
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3MCY
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5F2F
| Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to FimH lectin domain | 分子名称: | 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL, Protein FimH | 著者 | Kalas, V, Hultgren, S.J. | 登録日 | 2015-12-01 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.665 Å) | 主引用文献 | Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. Chemmedchem, 11, 2016
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3OHN
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3RFZ
| Crystal structure of the FimD usher bound to its cognate FimC:FimH substrate | 分子名称: | Chaperone protein fimC, Outer membrane usher protein, type 1 fimbrial synthesis, ... | 著者 | Phan, G, Remaut, H, Lebedev, A, Geibel, S, Waksman, G. | 登録日 | 2011-04-07 | 公開日 | 2011-06-01 | 最終更新日 | 2012-03-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature, 474, 2011
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2IKQ
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8VB1
| Crystal structure of HIV-1 protease with GS-9770 | 分子名称: | (2S)-2-{(3M)-4-chloro-3-[1-(difluoromethyl)-1H-1,2,4-triazol-5-yl]phenyl}-2-[(2E,4R)-4-[4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)phenyl]-2-imino-5-oxo-4-(3,3,3-trifluoro-2,2-dimethylpropyl)imidazolidin-1-yl]ethyl [1-(difluoromethyl)cyclopropyl]carbamate, HIV-1 protease | 著者 | Lansdon, E.B. | 登録日 | 2023-12-11 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob.Agents Chemother., 68, 2024
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4YD0
| Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor | 分子名称: | 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine, Polymerase basic protein 2 | 著者 | Jacobs, M.D. | 登録日 | 2015-02-20 | 公開日 | 2015-04-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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5JUR
| PB2 bound to an azaindole inhibitor | 分子名称: | (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethyl-pentanoic acid, Polymerase basic protein 2 | 著者 | Jacobs, M.D. | 登録日 | 2016-05-10 | 公開日 | 2017-03-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2. ACS Med Chem Lett, 8, 2017
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5JUN
| PB2 bound to an azaindole inhibitor | 分子名称: | (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-3-(1-methylcyclobutyl)propanoic acid, Polymerase basic protein 2 | 著者 | Jacobs, M.D. | 登録日 | 2016-05-10 | 公開日 | 2017-05-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2. ACS Med Chem Lett, 8, 2017
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4NCM
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4NCE
| Influenza polymerase basic protein 2 (PB2) bound to 7-methyl-GTP | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid, Polymerase basic protein 2 | 著者 | Jacobs, M.D. | 登録日 | 2013-10-24 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2. J.Med.Chem., 57, 2014
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4P1U
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