8DI2
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1JY9
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![BU of 1jy9 by Molmil](/molmil-images/mine/1jy9) | MINIMIZED AVERAGE STRUCTURE OF DP-TT2 | 分子名称: | DP-TT2 | 著者 | Stanger, H.E, Syud, F.A, Espinosa, J.F, Giriat, I, Muir, T, Gellman, S.H. | 登録日 | 2001-09-11 | 公開日 | 2001-09-19 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Length-dependent stability and strand length limits in antiparallel beta -sheet secondary structure. Proc.Natl.Acad.Sci.USA, 98, 2001
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6BFX
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![BU of 6bfx by Molmil](/molmil-images/mine/6bfx) | BACE crystal structure with hydroxy pyrrolidine inhibitor | 分子名称: | Beta-secretase 1, GLYCEROL, N-{(1S,2S)-3-(3,5-difluorophenyl)-1-[(3R,5S,6R)-6-(2,2-dimethylpropoxy)-5-methylmorpholin-3-yl]-1-hydroxypropan-2-yl}acetamide | 著者 | Timm, D.E. | 登録日 | 2017-10-27 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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6BFE
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![BU of 6bfe by Molmil](/molmil-images/mine/6bfe) | BACE crystal structure with hydroxy pyrrolidine inhibitor | 分子名称: | Beta-secretase 1, GLYCEROL, N-[(1R,2S)-1-[(2R,4R)-4-(cyclohexylmethoxy)pyrrolidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide | 著者 | Timm, D.E. | 登録日 | 2017-10-26 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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6BFD
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![BU of 6bfd by Molmil](/molmil-images/mine/6bfd) | BACE crystal structure with hydroxy pyrrolidine inhibitor | 分子名称: | 2-{[(2S)-butan-2-yl]amino}-N-{(1R,2S)-1-hydroxy-3-phenyl-1-[(2R)-pyrrolidin-2-yl]propan-2-yl}-6-(methylsulfonyl)pyridine-4-carboxamide, Beta-secretase 1, GLYCEROL | 著者 | Timm, D.E. | 登録日 | 2017-10-26 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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6BFW
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![BU of 6bfw by Molmil](/molmil-images/mine/6bfw) | BACE crystal structure with hydroxy morpholine inhibitor | 分子名称: | Beta-secretase 1, GLYCEROL, N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide | 著者 | Timm, D.E. | 登録日 | 2017-10-27 | 公開日 | 2017-11-15 | 最終更新日 | 2017-12-27 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. J. Med. Chem., 60, 2017
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8TCE
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8V8Z
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8V9B
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![BU of 8v9b by Molmil](/molmil-images/mine/8v9b) | Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732 | 分子名称: | (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ... | 著者 | Hendle, J, Weichert, K, Sauder, J.M. | 登録日 | 2023-12-07 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629, 2024
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7U6E
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7U6D
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