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X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M1 Alanyl Aminopeptidase from P. falciparum
分子名称:	(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2014-11-27
公開日	2015-02-18
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17. Proteins, 83, 2015

4X2T

X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M17 Leucyl Aminopeptidase from P. falciparum
分子名称:	(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid, CARBONATE ION, M17 leucyl aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2014-11-27
公開日	2015-02-18
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.729 Å)
主引用文献	X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17. Proteins, 83, 2015

4J4P

The complex of human IgE-Fc with two bound Fab fragments
分子名称:	Ig epsilon chain C region, Immunoglobulin G Fab Fragment Heavy Chain, Immunoglobulin G Fab Fragment Light Chain, ...
著者	Drinkwater, N, Sutton, B.J.
登録日	2013-02-07
公開日	2014-03-12
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.91 Å)
主引用文献	Human immunoglobulin E flexes between acutely bent and extended conformations. Nat.Struct.Mol.Biol., 21, 2014

5JQK

The Xray Crystal Structure of P. falciparum Aminopeptidase P
分子名称:	MANGANESE (II) ION, PHOSPHATE ION, Peptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2016-05-05
公開日	2016-08-31
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum. Biochem.J., 473, 2016

5JR6

The Xray Crystal Structure of P. falciparum Aminopeptidase P in Complex With Apstatin
分子名称:	Apstatin, MANGANESE (II) ION, PHOSPHATE ION, ...
著者	Drinkwater, N, McGowan, S.
登録日	2016-05-05
公開日	2016-08-31
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum. Biochem.J., 473, 2016

3HCF

Crystal Structure of hPNMT in Complex With 3-trifluoromethyl phenylethanolamine and AdoHcy
分子名称:	(1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol, 1,2-ETHANEDIOL, Phenylethanolamine N-methyltransferase, ...
著者	Drinkwater, N, Martin, J.L.
登録日	2009-05-06
公開日	2009-08-25
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.702 Å)
主引用文献	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009

3HCB

Crystal Structure of hPNMT in Complex With Noradrenochrome and AdoHcy
分子名称:	(3S)-3-hydroxy-2,3-dihydro-1H-indole-5,6-dione, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L, Gee, C.L.
登録日	2009-05-06
公開日	2009-08-25
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009

3HCD

Crystal Structure of hPNMT in Complex With Noradrenaline and AdoHcy
分子名称:	L-NOREPINEPHRINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-05-06
公開日	2009-08-25
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.392 Å)
主引用文献	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009

3HCA

Crystal Structure of E185Q hPNMT in Complex With Octopamine and AdoHcy
分子名称:	1,2-ETHANEDIOL, 4-(2R-AMINO-1-HYDROXYETHYL)PHENOL, Phenylethanolamine N-methyltransferase, ...
著者	Drinkwater, N, Martin, J.L.
登録日	2009-05-06
公開日	2009-08-25
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009

3HCC

Crystal Structure of hPNMT in Complex With anti-9-amino-5-(trifluromethyl) benzonorbornene and AdoHcy
分子名称:	(1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L, Gee, C.L, Puri, M.
登録日	2009-05-06
公開日	2009-08-25
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009

3HCE

Crystal Structure of E185D hPNMT in Complex With Octopamine and AdoHcy
分子名称:	4-(2R-AMINO-1-HYDROXYETHYL)PHENOL, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者	Drinkwater, N, Martin, J.L.
登録日	2009-05-06
公開日	2009-08-25
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.85 Å)
主引用文献	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009

4ZX5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f
分子名称:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY2

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10o
分子名称:	CARBONATE ION, DIMETHYL SULFOXIDE, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluorobiphenyl-4-yl)ethyl]-2,2-dimethylpropanamide, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-21
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW8

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY0

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10q
分子名称:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(thiophen-3-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-21
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX9

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10b
分子名称:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX8

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b
分子名称:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW7

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZYQ

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10s
分子名称:	CARBONATE ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, PENTAETHYLENE GLYCOL, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-22
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b
分子名称:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX4

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10b
分子名称:	DIMETHYL SULFOXIDE, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

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