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Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
分子名称:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide, ...
著者	Dasgupta, T, Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Nichols, S, Lyons, T.M, Tirado-Rives, J, Jorgensen, W.L, Yuthavong, Y, Anderson, K.S.
登録日	2008-06-13
公開日	2009-01-27
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.58 Å)
主引用文献	Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. Acs Chem.Biol., 4, 2009

Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
分子名称:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide, ...
著者	Dasgupta, T, Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Nichols, S, Lyons, T.M, Tirado-Rives, J, Jorgensen, W.L, Yuthavong, Y, Anderson, K.S.
登録日	2008-06-13
公開日	2009-01-27
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. Acs Chem.Biol., 4, 2009

The crystal structure of MtbTOP1 in complex with both G- and T-segments
分子名称:	ACETATE ION, DNA (5'-D(CPTPTPCPCPGPCPTPTPGPAPC)-3'), DNA topoisomerase 1, ...
著者	Tan, K, Tse-Dinh, Y.-C.
登録日	2022-05-25
公開日	2022-12-14
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.78 Å)
主引用文献	The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments. Nucleic Acids Res., 51, 2023