1N7I
| The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046 | 分子名称: | 8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | McMillan, F.M, Archbold, J, McLeish, M.J, Caine, J.M, Criscione, K.R, Grunewald, G.L, Martin, J.L. | 登録日 | 2002-11-15 | 公開日 | 2003-12-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J.Med.Chem., 47, 2004
|
|
1N7J
| The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor | 分子名称: | 7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | McMillan, F.M, Archbold, J, McLeish, M.J, Caine, J.M, Criscione, K.R, Grunewald, G.L, Martin, J.L. | 登録日 | 2002-11-15 | 公開日 | 2003-12-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J.Med.Chem., 47, 2004
|
|
2G8N
| Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy | 分子名称: | (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Drinkwater, N, Gee, C.L, Martin, J.L. | 登録日 | 2006-03-02 | 公開日 | 2006-09-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase J.Med.Chem., 49, 2006
|
|
3HCA
| |
3HCB
| Crystal Structure of hPNMT in Complex With Noradrenochrome and AdoHcy | 分子名称: | (3S)-3-hydroxy-2,3-dihydro-1H-indole-5,6-dione, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Drinkwater, N, Martin, J.L, Gee, C.L. | 登録日 | 2009-05-06 | 公開日 | 2009-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009
|
|
3HCD
| |
3HCC
| Crystal Structure of hPNMT in Complex With anti-9-amino-5-(trifluromethyl) benzonorbornene and AdoHcy | 分子名称: | (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Drinkwater, N, Martin, J.L, Gee, C.L, Puri, M. | 登録日 | 2009-05-06 | 公開日 | 2009-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422, 2009
|
|
3HCF
| |
3HCE
| |
4DM3
| Crystal structure of human PNMT in complex adohcy, resorcinol and imidazole | 分子名称: | IMIDAZOLE, Phenylethanolamine N-methyltransferase, RESORCINOL, ... | 著者 | Nair, P.C, Malde, A.K, Mark, A.E. | 登録日 | 2012-02-06 | 公開日 | 2012-04-25 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4001 Å) | 主引用文献 | Missing fragments: detecting cooperative binding in fragment-based drug design. ACS Med Chem Lett, 3, 2012
|
|
3KPY
| Crystal Structure of hPNMT in Complex AdoHcy and 6-Chlorooxindole | 分子名称: | 6-chloro-1,3-dihydro-2H-indol-2-one, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Drinkwater, N, Martin, J.L. | 登録日 | 2009-11-17 | 公開日 | 2010-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
|
|
3KQV
| Crystal Structure of hPNMT in Complex AdoHcy and Formanilide | 分子名称: | FORMANILIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Drinkwater, N, Martin, J.L. | 登録日 | 2009-11-17 | 公開日 | 2010-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
|
|
3KPW
| |
3KQP
| |
3KQT
| |
3KPU
| Crystal Structure of hPNMT in Complex AdoHcy and 4-quinolinol | 分子名称: | Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, quinolin-4-ol | 著者 | Drinkwater, N, Martin, J.L. | 登録日 | 2009-11-17 | 公開日 | 2010-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
|
|
3KR0
| |
3KR2
| |
3KQM
| |
3KQS
| |
3KPV
| Crystal Structure of hPNMT in Complex AdoHcy and Adenine | 分子名称: | ADENINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Drinkwater, N, Martin, J.L. | 登録日 | 2009-11-17 | 公開日 | 2010-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
|
|
3KQQ
| |
3KPJ
| |
3KQW
| |
3KQY
| |