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Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106
分子名称:	2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid, SULFATE ION, Transcriptional enhancer factor TEF-1
著者	Freire, F, Heinrich, T, Petersson, C, Schneider, R, Garg, S, Schwarz, D, Gunera, J, Seshire, A, Koetzner, L, Schlesiger, S, Musil, D, Schilke, H, Doerfel, B, Diehl, P, Boepple, P, Lemos, A.R, Sousa, P.M.F, Freire, F, Bandeiras, T.M, Carswell, E, Pearson, N, Sirohi, S, Hooker, M, Trivier, E, Broome, R, Balsiger, A, Crowden, A, Dillon, C, Wienke, D.
登録日	2022-04-11
公開日	2022-07-13
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.19 Å)
主引用文献	Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 . J.Med.Chem., 65, 2022

TEAD1/YAP in complex with a reversible inhibitor N-[(4-phenoxyphenyl)methyl]imidazo[1,2-a]pyridine-3-carboxamide
分子名称:	CHLORIDE ION, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-1, ...
著者	Musil, D, Freire, F.
登録日	2024-07-04
公開日	2024-10-16
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (2.214 Å)
主引用文献	Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold. Bioorg.Med.Chem.Lett., 114, 2024

Human TEAD3 in complex with 1-Cyclopentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
分子名称:	1-cyclopentylpyrazolo[3,4-b]pyridine-5-carboxylic acid, Transcriptional enhancer factor TEF-5
著者	Musil, D, Sousa, C.M.
登録日	2022-04-11
公開日	2022-07-13
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.095 Å)
主引用文献	Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 . J.Med.Chem., 65, 2022