5ICV
 
 | | Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue | | 分子名称: | MET-LYS-ALA-VAL-LIG, N-alpha-acetyltransferase 60, [5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)furan-2-yl]methyl (3R)-4-{[3-({(E)-2-[(2,2-dihydroxyethyl)sulfanyl]ethenyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate | | 著者 | Stove, S.I, Magin, R.S, Marmorstein, R, Arnesen, T. | | 登録日 | 2016-02-23 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Crystal Structure of the Golgi-Associated Human N alpha-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
Structure, 24, 2016
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5ICW
 | | Crystal structure of human NatF (hNaa60) homodimer bound to Coenzyme A | | 分子名称: | CHLORIDE ION, COENZYME A, N-alpha-acetyltransferase 60 | | 著者 | Stove, S.I, Magin, R.S, Marmorstein, R, Arnesen, T. | | 登録日 | 2016-02-23 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | | 主引用文献 | Crystal Structure of the Golgi-Associated Human N alpha-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
Structure, 24, 2016
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5WJD
 | | Crystal structure of Naa80 bound to acetyl-CoA | | 分子名称: | ACETYL COENZYME *A, CG8481, isoform B, ... | | 著者 | Goris, M, Magin, R.S, Marmorstein, R, Arnesen, T. | | 登録日 | 2017-07-21 | | 公開日 | 2018-03-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WJE
 | | Crystal structure of Naa80 bound to a bisubstrate analogue | | 分子名称: | Actin N-terminus peptide, CARBOXYMETHYL COENZYME *A, CG8481, ... | | 著者 | Goris, M, Magin, R.S, Marmorstein, R, Arnesen, T. | | 登録日 | 2017-07-21 | | 公開日 | 2018-03-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.765 Å) | | 主引用文献 | Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6PPL
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6PW9
 | | Cryo-EM structure of human NatE/HYPK complex | | 分子名称: | ACETYL COENZYME *A, Huntingtin-interacting protein K, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Deng, S, Marmorstein, R. | | 登録日 | 2019-07-22 | | 公開日 | 2020-02-19 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK.
Nat Commun, 11, 2020
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3TFY
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6NBW
 | | Ternary Complex of Beta/Gamma-Actin with Profilin and AnCoA-NAA80 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Rebowski, G, Boczkowska, M, Dominguez, R. | | 登録日 | 2018-12-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanism of actin N-terminal acetylation.
Sci Adv, 6, 2020
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6NAS
 | | Ternary Complex of Ac-Alpha-Actin with Profilin and AcCoA-NAA80 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Rebowski, G, Boczkowska, M, Dominguez, R. | | 登録日 | 2018-12-06 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Mechanism of actin N-terminal acetylation.
Sci Adv, 6, 2020
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6NBE
 | | Ternary Complex of Ac-Alpha-Actin with Profilin and CoA-NAA80 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Rebowski, G, Boczkowska, M, Dominguez, R. | | 登録日 | 2018-12-07 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mechanism of actin N-terminal acetylation.
Sci Adv, 6, 2020
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4KVO
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4KVM
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4KVX
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8PI9
 | | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A) | | 分子名称: | Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha | | 著者 | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
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8PI8
 | | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA | | 分子名称: | Chains: E, Chains: F, GLYCEROL, ... | | 著者 | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
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8PI7
 | | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -169C>T) | | 分子名称: | CHLORIDE ION, Chains: E, Chains: F, ... | | 著者 | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
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8PIA
 | | DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>T) | | 分子名称: | Chains: E, Chains: F, GLYCEROL, ... | | 著者 | Kind, L, Myllykoski, M, Raasakka, A, Kursula, P. | | 登録日 | 2023-06-21 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
JCI Insight, 9, 2024
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