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3HWK
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BU of 3hwk by Molmil
Crystal structure of methylcitrate synthase from Mycobacterium tuberculosis
分子名称: Methylcitrate synthase, SUCCINIC ACID
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-06-17
公開日2009-06-30
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
8UAI
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BU of 8uai by Molmil
Crystal structure of hetero hexameric hazelnut allergen Cor a 9
分子名称: 11S globulin 1, 11S globulin 2, 11S globulin 3, ...
著者Zhang, Y.Z, Guo, F.
登録日2023-09-21
公開日2024-05-15
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal structure of hetero hexameric 11S seed storage protein of hazelnut.
Plant Physiol Biochem., 210, 2024
3ICO
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BU of 3ico by Molmil
Crystal structure of 6-phosphogluconolactonase from Mycobacterium tuberculosis
分子名称: 6-phosphogluconolactonase, SULFATE ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-07-17
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
7K7Q
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BU of 7k7q by Molmil
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide
分子名称: 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2
著者Khan, J.A.
登録日2020-09-23
公開日2021-08-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J.Med.Chem., 64, 2021
7K7O
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BU of 7k7o by Molmil
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide
分子名称: 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2
著者Khan, J.A.
登録日2020-09-23
公開日2021-08-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J.Med.Chem., 64, 2021
6IV3
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BU of 6iv3 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation W252A
分子名称: Bestrophin homolog, ZINC ION
著者Kittredge, A, Chen, S, Yang, T.
登録日2018-12-02
公開日2019-11-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.515 Å)
主引用文献Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
4NFN
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BU of 4nfn by Molmil
Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol
分子名称: 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol, SULFATE ION, Tau-tubulin kinase 1
著者Sheriff, S.
登録日2013-10-31
公開日2014-02-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Acta Crystallogr F Struct Biol Commun, 70, 2014
5C90
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BU of 5c90 by Molmil
Staphylococcus aureus ClpP mutant - Y63A
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit
著者Ye, F, Liu, H, Zhang, J, Gan, J, Yang, C.-G.
登録日2015-06-26
公開日2016-05-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure
Acs Chem.Biol., 11, 2016
6E29
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BU of 6e29 by Molmil
Crystal structure of Myceliophteria_thermophila Cps50 (Swd1) beta-propeller domain
分子名称: SWD1-like protein
著者Joshi, M, Yang, Y, Brunzelle, J.S, Couture, J.F.
登録日2018-07-10
公開日2018-07-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.818 Å)
主引用文献Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell, 174, 2018
5M4Y
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BU of 5m4y by Molmil
Crystal structure of the Sec3/Sso2 complex at 2.20 angstrom resolution
分子名称: Exocyst complex component SEC3, GLYCEROL, Protein SSO2
著者Zhang, Y.B, Dong, G.
登録日2016-10-19
公開日2017-02-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.
Nat Commun, 8, 2017
1CC0
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BU of 1cc0 by Molmil
CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, rho GDP dissociation inhibitor alpha, ...
著者Longenecker, K.L, Read, P, Derewenda, U, Dauter, Z, Garrard, S, Walker, L, Somlyo, A.V, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S.
登録日1999-03-03
公開日2000-01-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (5 Å)
主引用文献How RhoGDI binds Rho.
Acta Crystallogr.,Sect.D, 55, 1999
3H7F
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BU of 3h7f by Molmil
Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis
分子名称: MAGNESIUM ION, Serine hydroxymethyltransferase 1
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-04-24
公開日2009-05-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
1CHZ
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BU of 1chz by Molmil
A NEW NEUROTOXIN FROM BUTHUS MARTENSII KARSCH
分子名称: CHLORIDE ION, PROTEIN (BMK M2)
著者He, X.L, Deng, J.P, Li, H.M, Wang, D.C.
登録日1999-03-31
公開日2000-03-31
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structure of a new neurotoxin from the scorpion Buthus martensii Karsch at 1.76 A.
Acta Crystallogr.,Sect.D, 56, 2000
3IFT
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BU of 3ift by Molmil
Crystal structure of glycine cleavage system protein H from Mycobacterium tuberculosis, using X-rays from the Compact Light Source.
分子名称: Glycine cleavage system H protein
著者Edwards, T.E, Abendroth, J, Staker, B, Mayer, C, Phan, I, Kelley, A, Analau, E, Leibly, D, Rifkin, J, Loewen, R, Ruth, R.D, Stewart, L.J, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
登録日2009-07-25
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.
J.Struct.Funct.Genom., 11, 2010
5LG4
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BU of 5lg4 by Molmil
Crystal structure of the Sec3/Sso2 complex at 2.9 angstrom resolution
分子名称: Exocyst complex component SEC3, Protein SSO2, SULFATE ION
著者Zhang, Y.B, Dong, G.
登録日2016-07-05
公開日2017-02-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.
Nat Commun, 8, 2017
4YKC
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BU of 4ykc by Molmil
Crystal structure of cerebral cavernous malformation 2 C-terminal adaptor domain
分子名称: Malcavernin
著者Ding, J, Wang, X, Wang, D.C.
登録日2015-03-04
公開日2015-06-03
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3
Structure, 23, 2015
6IV4
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BU of 6iv4 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation W252F
分子名称: Bestrophin homolog, ZINC ION
著者Kittredge, A, Chen, S, Yang, T.
登録日2018-12-02
公開日2019-11-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
6IV0
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BU of 6iv0 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation I180A
分子名称: Bestrophin homolog, ZINC ION
著者Kittredge, A, Chen, S, Yang, T.
登録日2018-12-02
公開日2019-11-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
6IVW
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BU of 6ivw by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation D269A
分子名称: Bestrophin homolog, ZINC ION
著者Kittredge, A, Chen, S, Yang, T.
登録日2018-12-04
公開日2019-11-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.72 Å)
主引用文献Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
5J8V
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BU of 5j8v by Molmil
Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion
分子名称: Ryanodine receptor 1
著者Wang, X, Wei, R, Yin, C, Sun, F.
登録日2016-04-08
公開日2016-09-14
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1
Cell Res., 26, 2016
6IV1
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BU of 6iv1 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation I180T
分子名称: Bestrophin homolog, ZINC ION
著者Kittredge, A, Chen, S, Yang, T.
登録日2018-12-02
公開日2019-11-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
6FKQ
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BU of 6fkq by Molmil
THE CRYSTAL STRUCTURE OF A FRAGMENT OF NETRIN-1 IN COMPLEX WITH A FRAGMENT OF DRAXIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Bhowmick, T, Meijers, R.
登録日2018-01-24
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.
Neuron, 97, 2018
3GTD
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BU of 3gtd by Molmil
2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii
分子名称: Fumarate hydratase class II, MALONATE ION, SODIUM ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-03-27
公開日2009-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.
Acta Crystallogr.,Sect.F, 67, 2011
3GVC
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BU of 3gvc by Molmil
Crystal structure of probable short-chain dehydrogenase-reductase from Mycobacterium tuberculosis
分子名称: Probable short-chain type dehydrogenase/reductase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-03-30
公開日2009-04-07
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
7EW9
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BU of 7ew9 by Molmil
GDP-bound KRAS G12D in complex with TH-Z816
分子名称: 7-(8-methylnaphthalen-1-yl)-4-[(2~{R})-2-methylpiperazin-1-yl]-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ...
著者Shen, P, Yang, Y, Yang, Y, Zhang, L, Chen, C.-C, Guo, R.-T.
登録日2021-05-25
公開日2021-12-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.
Cell Discov, 8, 2022

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