8TBK
| Tricomplex of RMC-7977, KRAS G12C, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8TBI
| Tricomplex of RMC-7977, NRAS WT, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase NRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8TBL
| Tricomplex of RMC-7977, KRAS G12D, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8TBM
| Tricomplex of RMC-7977, KRAS G12V, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GLYCEROL, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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8TBN
| Tricomplex of RMC-7977, KRAS G12S, and CypA | 分子名称: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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6K0Y
| Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor | 分子名称: | 1,2-ETHANEDIOL, Antibody Heavy Chain, Antibody Light Chain, ... | 著者 | Liu, J.X, Wang, G.Q. | 登録日 | 2019-05-08 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor. Sci Rep, 9, 2019
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7XCZ
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7XDK
| Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA7054 fab, ... | 著者 | Liu, Z, Lui, S, Gao, Y. | 登録日 | 2022-03-27 | 公開日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov, 9, 2023
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7XDB
| Cryo-EM structure of SARS-CoV-2 Omicron Spike protein in complex with BA7208 fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA7208 fab, ... | 著者 | Liu, Z, Liu, S, Gao, Y.Z. | 登録日 | 2022-03-26 | 公開日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov, 9, 2023
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7XDA
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7XDL
| Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA7125 fab, ... | 著者 | Liu, Z, Liu, S, Yuanzhu, G. | 登録日 | 2022-03-27 | 公開日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov, 9, 2023
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8X5E
| Cryo-EM structure of human XPR1 in open state | 分子名称: | PHOSPHATE ION, Solute carrier family 53 member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Jiang, D.H, Yan, R. | 登録日 | 2023-11-17 | 公開日 | 2024-07-03 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Human XPR1 structures reveal phosphate export mechanism. Nature, 633, 2024
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8X5F
| human XPR1 in complex with InsP6 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Jiang, D.H, Yan, R. | 登録日 | 2023-11-17 | 公開日 | 2024-07-03 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Human XPR1 structures reveal phosphate export mechanism. Nature, 633, 2024
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8X5B
| Cryo-EM structures of human XPR1 in closed states | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, PHOSPHATE ION, ... | 著者 | Jiang, D.H, Yan, R. | 登録日 | 2023-11-16 | 公開日 | 2024-07-03 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Human XPR1 structures reveal phosphate export mechanism. Nature, 633, 2024
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8D9N
| CryoEM structures of bAE1 captured in multiple states. | 分子名称: | Anion exchange protein | 著者 | Zhekova, H.R, Wang, W.G, Jiang, J.S, Tsirulnikov, K, Muhammad-Khan, G.H, Azimov, R, Abuladze, N, Kao, L, Newman, D, Noskov, S.Y, Tieleman, P, Zhou, Z.H, Pushkin, A, Kurtz, I. | 登録日 | 2022-06-10 | 公開日 | 2023-01-25 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations. Commun Biol, 5, 2022
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3JAY
| Atomic model of transcribing cytoplasmic polyhedrosis virus | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | 登録日 | 2015-07-06 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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8E34
| CryoEM structures of bAE1 captured in multiple states | 分子名称: | Anion exchange protein | 著者 | Zhekova, H.R, Wang, W.G, Jiang, J.S, Tsirulnikov, K, Muhammad-Khan, G.H, Azimov, R, Abuladze, N, Kao, L, Newman, D, Noskov, S.Y, Tieleman, P, Zhou, Z.H, Pushkin, A, Kurtz, I. | 登録日 | 2022-08-16 | 公開日 | 2023-01-25 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations. Commun Biol, 5, 2022
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3JB2
| Atomic model of cytoplasmic polyhedrosis virus with SAM and GTP | 分子名称: | Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | 登録日 | 2015-07-06 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JB3
| Atomic model of cytoplasmic polyhedrosis virus with SAM, GTP and ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | 登録日 | 2015-07-06 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JAZ
| Atomic model of cytoplasmic polyhedrosis virus with ATP | 分子名称: | Capsid protein VP1, Structural protein VP3, Viral structural protein 5 | 著者 | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | 登録日 | 2015-07-06 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JB0
| Atomic model of cytoplasmic polyhedrosis virus with GTP | 分子名称: | Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, Structural protein VP3, ... | 著者 | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | 登録日 | 2015-07-06 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JB1
| Atomic model of cytoplasmic polyhedrosis virus with SAM | 分子名称: | Capsid protein VP1, S-ADENOSYLMETHIONINE, Structural protein VP3, ... | 著者 | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | 登録日 | 2015-07-06 | 公開日 | 2015-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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8EEQ
| CryoEM structures of bAE1 captured in multiple states. | 分子名称: | Anion exchange protein | 著者 | Zhekova, H.R, Wang, W.G, Jiang, J.S, Tsirulnikov, K, Muhammad-Khan, G.H, Azimov, R, Abuladze, N, Kao, L, Newman, D, Noskov, S.Y, Tieleman, P, Zhou, Z.H, Pushkin, A, Kurtz, I. | 登録日 | 2022-09-07 | 公開日 | 2023-01-25 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations. Commun Biol, 5, 2022
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5GPP
| Crystal structure of zebrafish ASC PYD domain | 分子名称: | ACETATE ION, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, ... | 著者 | Jin, T, Li, Y. | 登録日 | 2016-08-04 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Functional and structural characterization of zebrafish ASC. FEBS J., 285, 2018
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5GPQ
| Crystal Structure of zebrafish ASC CARD Domain | 分子名称: | CITRIC ACID, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Jin, T, Li, Y. | 登録日 | 2016-08-04 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional and structural characterization of zebrafish ASC. FEBS J., 285, 2018
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