6MCB
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4YN7
| Non-oxidized YfiR | 分子名称: | SULFATE ION, YfiR | 著者 | Yang, X, Jiang, T. | 登録日 | 2015-03-09 | 公開日 | 2015-04-22 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states Biochem.Biophys.Res.Commun., 461, 2015
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1FT4
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5HDA
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3FKT
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7BUA
| Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, SIgN-3C Fab heavy chain, ... | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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7BR8
| Epstein-Barr virus, C5 penton vertex, CATC absent. | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | 著者 | Li, Z, Yu, X. | 登録日 | 2020-03-26 | 公開日 | 2020-09-30 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Res., 30, 2020
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7BUD
| Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 8.0 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dengue virus serotype 2 E protein, ... | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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4FOD
| Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36 | 分子名称: | 4-fluoro-N-{(2E)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2H-benzimidazol-2-ylidene}benzamide, ALK tyrosine kinase receptor, GLYCEROL | 著者 | Whittington, D.A, Epstein, L.F, Chen, H. | 登録日 | 2012-06-20 | 公開日 | 2012-07-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer. J.Med.Chem., 55, 2012
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7BSI
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7BUE
| Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0 | 分子名称: | Dengue serotype 2 E protein ectodomain, SIgN-3C Fab heavy chain, SIgN-3C Fab light chain | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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7BQT
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7BU8
| Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, SIgN-3C Fab heavy chain, ... | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-05 | 公開日 | 2020-05-13 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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7BQX
| Epstein-Barr virus, C5 portal vertex | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | 著者 | Li, Z, Yu, X. | 登録日 | 2020-03-25 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Res., 30, 2020
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7BR7
| Epstein-Barr virus, C1 portal-proximal penton vertex, CATC binding | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | 著者 | Li, Z, Yu, X. | 登録日 | 2020-03-26 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Res., 30, 2020
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7BUB
| Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 6.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dengue virus serotype 2 M protein, ... | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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7BUF
| Cryo-EM structure of Dengue virus serotype 2 complexed with SIgN-3C IgG | 分子名称: | Dengue virus serotype 2 E protein, Dengue virus serotype 2 M protein, SIgN-3C IgG heavy chain, ... | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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4FOB
| Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1 | 分子名称: | ALK tyrosine kinase receptor, N-{1-[cis-4-(hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)-1H-benzimidazol-2-yl}-3-(prop-2-en-1-ylsulfamoyl)benzamide | 著者 | Whittington, D.A, Epstein, L.F, Chen, H. | 登録日 | 2012-06-20 | 公開日 | 2012-07-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer. J.Med.Chem., 55, 2012
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4FOC
| Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2 | 分子名称: | ALK tyrosine kinase receptor, methyl cis-4-[2-(benzoylamino)-6-(piperidin-1-ylmethyl)-1H-benzimidazol-1-yl]cyclohexanecarboxylate | 著者 | Whittington, D.A, Epstein, L.F, Chen, H. | 登録日 | 2012-06-20 | 公開日 | 2012-07-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer. J.Med.Chem., 55, 2012
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7DRT
| Human Wntless in complex with Wnt3a | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhong, Q, Zhao, Y, Ye, F, Xiao, Z, Huang, G, Zhang, Y, Lu, P, Xu, W, Zhou, Q, Ma, D. | 登録日 | 2020-12-29 | 公開日 | 2021-07-14 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Cryo-EM structure of human Wntless in complex with Wnt3a. Nat Commun, 12, 2021
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3HDF
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7EFT
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8HTR
| Crystal structure of Bcl2 in complex with S-9c | 分子名称: | 4-[4-[(2~{S})-2-(2-chlorophenyl)pyrrolidin-1-yl]phenyl]-~{N}-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide, Apoptosis regulator Bcl-2 | 著者 | Liu, J, Xu, M, Feng, Y, Liu, Y. | 登録日 | 2022-12-21 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2. J.Med.Chem., 67, 2024
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8HTS
| Crystal structure of Bcl2 in complex with S-10r | 分子名称: | 4-[2-[(2~{S})-2-(2-cyclopropylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-~{N}-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide, Apoptosis regulator Bcl-2 | 著者 | Liu, J, Xu, M, Feng, Y, Liu, Y. | 登録日 | 2022-12-21 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2. J.Med.Chem., 67, 2024
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8GK7
| MsbA bound to cerastecin C | 分子名称: | 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid, Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Chen, Y, Klein, D. | 登録日 | 2023-03-17 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii. Nat Microbiol, 9, 2024
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