7P4B
| HLA-E*01:03 in complex with IL9 | 分子名称: | Beta-2-microglobulin, ESAT-6-like protein EsxH, GLYCEROL, ... | 著者 | Walters, L.C, Gillespie, G.M. | 登録日 | 2021-07-10 | 公開日 | 2022-07-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes. Cell Rep, 39, 2022
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7PA0
| NaK C-DI F92A mutant with Rb+ and K+ | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... | 著者 | Minniberger, S, Plested, A.J.R. | 登録日 | 2021-07-28 | 公開日 | 2022-08-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7OPH
| NaK S-DI mutant with Na+ and K+ | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | 著者 | Minniberger, S, Plested, A.J.R. | 登録日 | 2021-05-31 | 公開日 | 2022-06-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7OOR
| NaK C-DI mutant with Na+ and K+ | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | 著者 | Minniberger, S, Plested, A.J.R. | 登録日 | 2021-05-28 | 公開日 | 2022-06-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7OOU
| NaK C-DI mutant with Li+ and K+ | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | 著者 | Minniberger, S, Plested, A.J.R. | 登録日 | 2021-05-28 | 公開日 | 2022-06-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7P49
| HLA-E*01:03 in complex with Mtb14 | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | 著者 | Walters, L.C, Gillespie, G.M. | 登録日 | 2021-07-10 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes. Cell Rep, 39, 2022
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7OQ1
| NaK S-ELM mutant with Na+ and K+ | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | 著者 | Minniberger, S, Plested, A.J.R. | 登録日 | 2021-06-02 | 公開日 | 2022-06-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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7OQ2
| NaK S-DI mutant soaked in Na+ | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Minniberger, S, Plested, A.J.R. | 登録日 | 2021-06-02 | 公開日 | 2022-06-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
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3F4M
| Crystal structure of TIPE2 | 分子名称: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | 著者 | Zhang, X, Wang, J, Shi, Y. | 登録日 | 2008-11-01 | 公開日 | 2009-03-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Crystal structure of TIPE2 provides insights into immune homeostasis Nat.Struct.Mol.Biol., 16, 2009
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3HH8
| Crystal Structure and metal binding properties of the lipoprotein MtsA | 分子名称: | FE (III) ION, Metal ABC transporter substrate-binding lipoprotein | 著者 | Baker, E.N, Baker, H.M, Sun, X, Ye, Q.-Y. | 登録日 | 2009-05-15 | 公開日 | 2009-06-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry, 48, 2009
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7W0G
| Human PPAR delta ligand binding domain in complex with a synthetic agonist H11 | 分子名称: | 2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta | 著者 | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | 登録日 | 2021-11-18 | 公開日 | 2022-02-02 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.443 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPAR alpha / delta Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J.Med.Chem., 65, 2022
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7KXD
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7KXE
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7KXF
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5B5R
| Crystal structure of GSDMA3 | 分子名称: | Gasdermin-A3 | 著者 | Ding, J, Shao, F. | 登録日 | 2016-05-14 | 公開日 | 2016-06-15 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | Pore-forming activity and structural autoinhibition of the gasdermin family. Nature, 535, 2016
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8JBJ
| Crystal structure of anti-PVRIG Fab | 分子名称: | antibody heavy chain, antibody light chain | 著者 | Sun, J, Li, X.L, Song, J. | 登録日 | 2023-05-09 | 公開日 | 2023-06-21 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity. Mabs, 15, 2023
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6R5F
| Crystal structure of RIP1 kinase in complex with DHP77 | 分子名称: | Receptor-interacting serine/threonine-protein kinase 1, [(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone | 著者 | Thorpe, J.H, Campobasso, N, Harris, P.A. | 登録日 | 2019-03-25 | 公開日 | 2019-05-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J.Med.Chem., 62, 2019
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8COI
| Human adenovirus-derived synthetic ADDobody binder | 分子名称: | ADDobody | 著者 | Buzas, D, Toelzer, C, Gupta, K, Berger-Schaffitzel, C, Berger, I. | 登録日 | 2023-02-28 | 公開日 | 2023-12-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders. Structure, 32, 2024
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8H3G
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166V Mutant in Complex with Inhibitor Enstrelvir | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | 登録日 | 2022-10-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H3L
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (T21I and E166V) in Complex with Inhibitor Enstrelvir | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | 登録日 | 2022-10-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H3K
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (L50F and E166V) in Complex with Inhibitor Enstrelvir | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, ... | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | 登録日 | 2022-10-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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2JW2
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2KDX
| Solution structure of HypA protein | 分子名称: | Hydrogenase/urease nickel incorporation protein hypA, ZINC ION | 著者 | Xia, W, Li, H, Sze, K.-H. | 登録日 | 2009-01-20 | 公開日 | 2009-10-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a nickel chaperone, HypA, from Helicobacter pylori reveals two distinct metal binding sites J.Am.Chem.Soc., 131, 2009
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8H57
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) A193P Mutant in Complex with Inhibitor Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Lin, M, Liu, X. | 登録日 | 2022-10-12 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H4Y
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) F140L Mutant in Complex with Inhibitor Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Lin, M, Liu, X. | 登録日 | 2022-10-11 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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