6BR2
 
 | | Structure of RORgt in complex with a novel isoquinoline inverse agonist. | | 分子名称: | (1R)-N-(4-tert-butyl-3-fluorophenyl)-6-methoxy-2-[(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxamide, (4S)-2-METHYL-2,4-PENTANEDIOL, Nuclear receptor ROR-gamma | | 著者 | Skene, R.J, Hoffman, I. | | 登録日 | 2017-11-29 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist.
J. Med. Chem., 61, 2018
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6BR3
 | | Structure of RORgt in complex with a novel inverse agonist TAK-828. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Nuclear receptor ROR-gamma, {cis-3-[(5R)-5-[(7-fluoro-1,1-dimethyl-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carbonyl]cyclobutyl}acetic acid | | 著者 | Skene, R.J, Hoffman, I. | | 登録日 | 2017-11-29 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist.
J. Med. Chem., 61, 2018
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4RSJ
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2RVM
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2RVN
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2RVL
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5X2E
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5X2D
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4XE8
 | | Bacillus thuringiensis ParM with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein | | 著者 | Jiang, S.M, Robinson, R.C. | | 登録日 | 2014-12-23 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.381 Å) | | 主引用文献 | A novel plasmid-segregating actin-like protein from Bacillus thuringiensis forms dynamically unstable tubules
to be published
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4XE7
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4XHN
 | | Bacillus thuringiensis ParM with AMPPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Uncharacterized protein | | 著者 | Jiang, S.M, Robinson, R.C. | | 登録日 | 2015-01-06 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A novel plasmid-segregating actin-like protein from Bacillus thuringiensis forms dynamically unstable tubules
to be published
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4XHO
 | | Bacillus thuringiensis ParM with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein | | 著者 | Jiang, S.M, Robinson, R.C. | | 登録日 | 2015-01-06 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | A novel plasmid-segregating actin-like protein from Bacillus thuringiensis forms dynamically unstable tubules
to be published
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4XHP
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3WKL
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5YU8
 | | Cofilin decorated actin filament | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Tanaka, K, Narita, A. | | 登録日 | 2017-11-21 | | 公開日 | 2018-05-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis for cofilin binding and actin filament disassembly
Nat Commun, 9, 2018
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6AHT
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6B33
 | | Structure of RORgt in complex with a novel inverse agonist 3 | | 分子名称: | (2R)-N~2~-(3-chloro-4-cyanophenyl)-N~4~-[3-(cyclopropylmethyl)-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]morpholine-2,4-dicarboxamide, Nuclear receptor ROR-gamma | | 著者 | Skene, R.J, Hoffman, I, Snell, G. | | 登録日 | 2017-09-20 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Design and Synthesis of Conformationally Constrained ROR gamma t Inverse Agonists.
Chemmedchem, 2019
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3AN2
 | | The structure of the centromeric nucleosome containing CENP-A | | 分子名称: | 147 mer DNA, Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Tachiwana, H, Kagawa, W, Shiga, T, Saito, K, Osakabe, A, Hayashi-Takanaka, Y, Park, S.-Y, Kimura, H, Kurumizaka, H. | | 登録日 | 2010-08-27 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of the human centromeric nucleosome containing CENP-A
Nature, 476, 2011
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6LJD
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6KWZ
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6LJF
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6LJC
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6LJE
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3ASK
 | | Structure of UHRF1 in complex with histone tail | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ZINC ION | | 著者 | Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. | | 登録日 | 2010-12-16 | | 公開日 | 2012-01-25 | | 最終更新日 | 2013-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.904 Å) | | 主引用文献 | Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
Proc.Natl.Acad.Sci.USA, 109, 2012
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3ASL
 | | Structure of UHRF1 in complex with histone tail | | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ... | | 著者 | Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. | | 登録日 | 2010-12-16 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
Proc.Natl.Acad.Sci.USA, 109, 2012
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