Search by PDB author

Crystal Structure of Dok1 PTB Domain Complex
分子名称:	13-mer peptide from Proto-oncogene tyrosine-protein kinase receptor ret, Docking protein 1
著者	Shi, N, Ye, S, Liu, Y, Zhou, W, Ding, Y, Lou, Z, Qiang, B, Yan, J, Rao, Z.
登録日	2003-05-14
公開日	2004-05-25
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain J.Biol.Chem., 279, 2004

5HGU

Crystal structure of human transcription factor TEAD2 in complex with palmitate
分子名称:	PALMITIC ACID, Transcriptional enhancer factor TEF-4
著者	Luo, X, Xiao, H.
登録日	2016-01-08
公開日	2016-02-17
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.046 Å)
主引用文献	Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Nat.Chem.Biol., 12, 2016

5M02

Crystal structure of murine P14 TCR / H-2Db with PF, modified gp33 peptide from LCMV
分子名称:	Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ...
著者	Achour, A, Sandalova, T, Sun, R.
登録日	2016-10-03
公開日	2017-12-20
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Thernary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant To Be Published

3IOP

PDK-1 in complex with the inhibitor Compound-8i
分子名称:	2-(5-{[(2R)-2-amino-3-phenylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine, 3-phosphoinositide-dependent protein kinase 1
著者	Olland, A.M.
登録日	2009-08-14
公開日	2010-02-16
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1). Eur.J.Med.Chem., 45, 2010

3ION

PDK1 in complex with Compound 8h
分子名称:	2-(5-{[(2S)-2-amino-3-phenylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine, 3-phosphoinositide-dependent protein kinase 1, SULFATE ION
著者	Olland, A.M.
登録日	2009-08-14
公開日	2010-02-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1). Eur.J.Med.Chem., 45, 2010

6CDY

Crystal structure of TEAD complexed with its inhibitor
分子名称:	2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide, Transcriptional enhancer factor TEF-4
著者	LIU, S, HAN, X, LUO, X.
登録日	2018-02-09
公開日	2020-07-01
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.32 Å)
主引用文献	Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell, 26, 2020

6JK8

Cryo-EM structure of the full-length human IGF-1R in complex with insulin
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
著者	Zhang, X, Yu, D, Wang, T.
登録日	2019-02-27
公開日	2020-03-04
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.7 Å)
主引用文献	Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. Structure, 28, 2020

3LPC

Crystal structure of a subtilisin-like protease
分子名称:	ACETATE ION, AprB2, CALCIUM ION, ...
著者	Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M.
登録日	2010-02-05
公開日	2010-12-08
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010

3LPA

Crystal structure of a subtilisin-like protease
分子名称:	Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION
著者	Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M.
登録日	2010-02-05
公開日	2010-12-08
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010

3LPD

Crystal structure of a subtilisin-like protease
分子名称:	Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION
著者	Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M.
登録日	2010-02-05
公開日	2010-12-08
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010

6LNK

Candida albicans Fructose-1,6-bisphosphate aldolase
分子名称:	1,2-ETHANEDIOL, Fructose-bisphosphate aldolase, ZINC ION
著者	Huang, Y, Cao, H, Ren, Y, Wan, J.
登録日	2019-12-30
公開日	2020-12-30
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.639 Å)
主引用文献	Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65, 2022

6VN2

USP7 IN COMPLEX WITH LIGAND COMPOUND 18
分子名称:	1-({7-[(2R)-5-chloro-2-(piperazine-1-carbonyl)-2,3-dihydro-1-benzofuran-7-yl]thieno[3,2-b]pyridin-2-yl}methyl)-1H-pyrrole-2,5-dione, ACETATE ION, Ubiquitin carboxyl-terminal hydrolase 7
著者	Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M.
登録日	2020-01-29
公開日	2020-04-29
最終更新日	2020-06-17
実験手法	X-RAY DIFFRACTION (2.93 Å)
主引用文献	Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020

6VN3

USP7 IN COMPLEX WITH LIGAND COMPOUND 23
分子名称:	1-{[7-(5-chloro-2-{[(3R,4S)-4-fluoropyrrolidin-3-yl]oxy}-3-methylphenyl)thieno[3,2-b]pyridin-2-yl]methyl}-1H-pyrrole-2,5-dione, Ubiquitin carboxyl-terminal hydrolase 7
著者	Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M.
登録日	2020-01-29
公開日	2020-04-29
最終更新日	2020-06-17
実験手法	X-RAY DIFFRACTION (2.73 Å)
主引用文献	Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020

6VN6

USP7 IN COMPLEX WITH LIGAND COMPOUND 14
分子名称:	Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION, [(2R)-5-chloro-7-{2-[(2S)-1-chloro-2,3-dihydroxypropan-2-yl]thieno[3,2-b]pyridin-7-yl}-2,3-dihydro-1-benzofuran-2-yl](piperazin-1-yl)methanone
著者	Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M.
登録日	2020-01-29
公開日	2020-04-29
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.99 Å)
主引用文献	Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020

3WGN

STAPHYLOCOCCUS AUREUS FTSZ bound with GTP-gamma-S
分子名称:	5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein FtsZ
著者	Matsui, T, Mogi, N, Tanaka, I, Yao, M.
登録日	2013-08-06
公開日	2013-12-25
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.606 Å)
主引用文献	Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop J.Biol.Chem., 289, 2014

6VN5

USP7 IN COMPLEX WITH LIGAND COMPOUND 7
分子名称:	Ubiquitin carboxyl-terminal hydrolase 7, [(2R)-7-(2-aminopyridin-4-yl)-5-chloro-2,3-dihydro-1-benzofuran-2-yl](piperazin-1-yl)methanone
著者	Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M.
登録日	2020-01-29
公開日	2020-04-29
最終更新日	2020-06-10
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020

6VN4

USP7 IN COMPLEX WITH LIGAND COMPOUND 1
分子名称:	3-({4-hydroxy-1-[(2R)-2-methyl-3-phenylpropanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7
著者	Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M.
登録日	2020-01-29
公開日	2020-04-29
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.69 Å)
主引用文献	Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020

3WGJ

STAPHYLOCOCCUS AUREUS FTSZ T7 chimera mutant, T7Bs
分子名称:	CALCIUM ION, Cell division protein FtsZ
著者	Matsui, T, Tanaka, I, Yao, M.
登録日	2013-08-06
公開日	2013-12-25
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.179 Å)
主引用文献	Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop J.Biol.Chem., 289, 2014

3DI6

HIV-1 RT with pyridazinone non-nucleoside inhibitor
分子名称:	6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one, Reverse transcriptase/ribonuclease H, p51 RT
著者	Harris, S.F, Villasenor, A, Dunten, P.
登録日	2008-06-19
公開日	2008-08-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 18, 2008

8KHU

Hepatitis B virus core protein Y132A mutant in complex with THPP derivatives 48
分子名称:	(6~{S},7~{R})-6,7-dimethyl-3-(2-oxidanylidenepyrrolidin-1-yl)-~{N}-[3,4,5-tris(fluoranyl)phenyl]-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-5-carboxamide, Capsid protein, GLYCEROL, ...
著者	Zhou, Z, Xu, Z.H.
登録日	2023-08-22
公開日	2023-10-25
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus. J.Med.Chem., 66, 2023

4IZY

Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
分子名称:	C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[4-(methylsulfonyl)piperidin-1-yl]-1H-indol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
著者	Kuglstatter, A, Shao, A.
登録日	2013-01-30
公開日	2013-12-18
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties. Bioorg.Med.Chem.Lett., 23, 2013

4KJU

Crystal structure of XIAP-Bir2 with a bound benzodiazepinone inhibitor.
分子名称:	E3 ubiquitin-protein ligase XIAP, N-{(3S)-5-(4-aminobenzoyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N~2~-methyl-L-alaninamide, ZINC ION
著者	Lukacs, C.M, Janson, C.A.
登録日	2013-05-03
公開日	2013-11-27
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain. J.Med.Chem., 56, 2013

5J5N

Crystal structure of the R39W mutant of Populus trichocarpa glutathione transferase PtGSTU30 in complex with glutathione
分子名称:	GLUTATHIONE, Glutathione transferase family protein
著者	Yang, Q, Gu, J, Yang, M, Zeng, Q.
登録日	2016-04-03
公開日	2017-04-12
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.629 Å)
主引用文献	Functional and Structural Profiles of GST Gene Family from Three Populus Species Revealed the Sequence-function Decoupling of Orthologous Genes To Be Published

4KJV

Crystal structure of XIAP-Bir2 with a bound spirocyclic benzoxazepinone inhibitor.
分子名称:	6-methoxy-5-({(3S)-3-[(N-methyl-L-alanyl)amino]-4-oxo-2',3,3',4,5',6'-hexahydro-5H-spiro[1,5-benzoxazepine-2,4'-pyran]-5-yl}methyl)naphthalene-2-carboxylic acid, E3 ubiquitin-protein ligase XIAP, ZINC ION
著者	Lukacs, C.M, Janson, C.A.
登録日	2013-05-03
公開日	2013-11-27
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain. J.Med.Chem., 56, 2013

5DBI

Crystal Structure of Iridoid Synthase from Cantharanthus roseus in complex with NAD+ and 10-oxogeranial
分子名称:	(2E,6E)-2,6-dimethylocta-2,6-dienedial, Iridoid synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者	Hu, Y.M, Liu, W.D, Zheng, Y.Y, Xu, Z.X, Ko, T.P, Chen, C.C, Guo, R.T.
登録日	2015-08-21
公開日	2015-11-04
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms Angew.Chem.Int.Ed.Engl., 54, 2015

<1 2 3 4 5 678 9 >

全ヒット件数:	225
表示件数:	25
表示順	関連性が高い順