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CRYSTAL STRUCTURES OF METYRAPONE-AND PHENYLIMIDAZOLE-INHIBITED COMPLEXES OF CYTOCHROME P450-CAM
分子名称:	1-phenyl-1H-imidazole, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE
著者	Poulos, T.L.
登録日	1992-07-27
公開日	1993-10-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam. Biochemistry, 26, 1987

1PHG

CRYSTAL STRUCTURES OF METYRAPONE-AND PHENYLIMIDAZOLE-INHIBITED COMPLEXES OF CYTOCHROME P450-CAM
分子名称:	CYTOCHROME P450-CAM, METYRAPONE, PROTOPORPHYRIN IX CONTAINING FE
著者	Poulos, T.L.
登録日	1992-07-27
公開日	1993-10-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam. Biochemistry, 26, 1987

1PHE

CRYSTAL STRUCTURES OF METYRAPONE-AND PHENYLIMIDAZOLE-INHIBITED COMPLEXES OF CYTOCHROME P450-CAM
分子名称:	2-phenyl-1H-imidazole, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE, ...
著者	Poulos, T.L.
登録日	1992-07-27
公開日	1993-10-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam. Biochemistry, 26, 1987

1PHF

CRYSTAL STRUCTURES OF METYRAPONE-AND PHENYLIMIDAZOLE-INHIBITED COMPLEXES OF CYTOCHROME P450-CAM
分子名称:	4-PHENYL-1H-IMIDAZOLE, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE
著者	Poulos, T.L.
登録日	1992-07-27
公開日	1993-10-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam. Biochemistry, 26, 1987

1GJM

Covalent attachment of an electroactive sulphydryl reagent in the active site of cytochrome P450cam
分子名称:	CYTOCHROME P450-CAM, N-(2-FERROCENYLETHYL)MALEIMIDE, PROTOPORPHYRIN IX CONTAINING FE
著者	Fulop, V.
登録日	2001-07-26
公開日	2001-07-31
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Covalent Attachment of an Electroactive Sulphydryl Reagent in the Active Site of Cytochrome P450Cam as Revealed by the Crystal Structure of the Modified Protein J.Am.Chem.Soc., 120, 1998

1AK9

SUBTILISIN MUTANT 8321
分子名称:	CALCIUM ION, ISOPROPYL ALCOHOL, SODIUM ION, ...
著者	Whitlow, M, Howard, A.J, Wood, J.F.
登録日	1997-05-30
公開日	1997-11-12
最終更新日	2021-11-03
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding. Biochemistry, 28, 1989

1AQN

SUBTILISIN MUTANT 8324
分子名称:	CALCIUM ION, ISOPROPYL ALCOHOL, SUBTILISIN 8324, ...
著者	Whitlow, M, Howard, A.J, Wood, J.F.
登録日	1997-07-31
公開日	1998-01-14
最終更新日	2021-11-03
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Large increases in general stabilityfor subtilisin BPN' through incremental changes in the free energy of unfolding To be published

1AU9

SUBTILISIN BPN' MUTANT 8324 IN CITRATE
分子名称:	CALCIUM ION, ISOPROPYL ALCOHOL, SUBTILISIN BPN', ...
著者	Whitlow, M, Howard, A.J, Wood, J.F.
登録日	1997-09-12
公開日	1997-12-31
最終更新日	2021-11-03
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding. Biochemistry, 28, 1989

4CCP

X-RAY STRUCTURES OF RECOMBINANT YEAST CYTOCHROME C PEROXIDASE AND THREE HEME-CLEFT MUTANTS PREPARED BY SITE-DIRECTED MUTAGENESIS
分子名称:	PROTOPORPHYRIN IX CONTAINING FE, YEAST CYTOCHROME C PEROXIDASE
著者	Wang, J, Mauro, J.M, Edwards, S.L, Oatley, S.J, Fishel, L.A, Ashford, V.A, Xuong, N.-H, Kraut, J.
登録日	1990-02-28
公開日	1991-07-15
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	X-ray structures of recombinant yeast cytochrome c peroxidase and three heme-cleft mutants prepared by site-directed mutagenesis. Biochemistry, 29, 1990

2IFF

STRUCTURE OF AN ANTIBODY-LYSOZYME COMPLEX: EFFECT OF A CONSERVATIVE MUTATION
分子名称:	HEN EGG WHITE LYSOZYME, IGG1 HYHEL-5 FAB (HEAVY CHAIN), IGG1 HYHEL-5 FAB (LIGHT CHAIN)
著者	Chacko, S, Davies, D.R.
登録日	1994-02-03
公開日	1994-05-31
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	Structure of an antibody-lysozyme complex unexpected effect of conservative mutation. J.Mol.Biol., 245, 1995

2I4Q

Human renin/PF02342674 complex
分子名称:	(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE, Renin
著者	Holsworth, D.D, Jalaie, M, Zhang, E, Mcconnell, P, Mochalkin, I, Finzel, B.C.
登録日	2006-08-22
公開日	2006-10-24
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. Bioorg.Med.Chem., 15, 2007

6CP4

P450CAM D251N MUTANT
分子名称:	CAMPHOR, CYTOCHROME P450CAM, GLYCEROL, ...
著者	Li, H, Poulos, T.L.
登録日	1998-05-28
公開日	1998-09-16
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect. Biochemistry, 37, 1998

6CCP

EFFECT OF ARGININE-48 REPLACEMENT ON THE REACTION BETWEEN CYTOCHROME C PEROXIDASE AND HYDROGEN PEROXIDE
分子名称:	CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
著者	Wang, J, Miller, M.A, Kraut, J.
登録日	1993-06-07
公開日	1993-10-31
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Effect of arginine-48 replacement on the reaction between cytochrome c peroxidase and hydrogen peroxide. Biochemistry, 32, 1993

4XIS

A METAL-MEDIATED HYDRIDE SHIFT MECHANISM FOR XYLOSE ISOMERASE BASED ON THE 1.6 ANGSTROMS STREPTOMYCES RUBIGINOSUS STRUCTURES WITH XYLITOL AND D-XYLOSE
分子名称:	D-xylose, MANGANESE (II) ION, XYLOSE ISOMERASE, ...
著者	Whitlow, M, Howard, A.J.
登録日	1991-03-25
公開日	1992-07-15
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 A Streptomyces rubiginosus structures with xylitol and D-xylose. Proteins, 9, 1991

4WYF

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a DSF fragment hit
分子名称:	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, N-(1-oxo-1H-inden-5-yl)acetamide, PYRIDOXAL-5'-PHOSPHATE
著者	Barry, C.F, Dai, R.
登録日	2014-11-17
公開日	2015-07-08
最終更新日	2015-07-22
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015

1UYU

Xenon COMPLEX OF wildtype P450CAM FROM PSEUDOMONAS PUTIDA
分子名称:	CAMPHOR, CYTOCHROME P450-CAM, POTASSIUM ION, ...
著者	Wade, R.C, Winn, P.J, Schlichting, I, Sudarko, X.
登録日	2004-03-02
公開日	2005-03-07
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	A Survey of Active Site Access Channels in Cytochromes P450 J.Inorg.Biochem., 98, 2004

2C2C

REFINEMENT OF THE CRYSTAL STRUCTURE OF OXIDIZED RHODOSPIRILLUM RUBRUM CYTOCHROME C2
分子名称:	CYTOCHROME C2, HEME C
著者	Bhatia, G, Finzel, B.C, Kraut, J.
登録日	1983-11-03
公開日	1984-02-02
最終更新日	2021-03-03
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Refinement of the Crystal Structure of Oxidized Rhodospirillum Rubrum Cytochrome C2 Thesis, 1981

2CCP

X-RAY STRUCTURES OF RECOMBINANT YEAST CYTOCHROME C PEROXIDASE AND THREE HEME-CLEFT MUTANTS PREPARED BY SITE-DIRECTED MUTAGENESIS
分子名称:	PROTOPORPHYRIN IX CONTAINING FE, YEAST CYTOCHROME C PEROXIDASE
著者	Wang, J, Mauro, J.M, Edwards, S.L, Oatley, S.J, Fishel, L.A, Ashford, V.A, Xuong, N.-H, Kraut, J.
登録日	1990-02-28
公開日	1991-07-15
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	X-ray structures of recombinant yeast cytochrome c peroxidase and three heme-cleft mutants prepared by site-directed mutagenesis. Biochemistry, 29, 1990

2CEP

ROLE OF MET-230 IN INTRAMOLECULAR ELECTRON TRANSFER BETWEEN THE OXYFERRYL HEME AND TRP 191 IN CYTOCHROME C PEROXIDASE COMPOUND II
分子名称:	CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
著者	Han, G.W, Miller, M.A, Kraut, J.
登録日	1994-05-31
公開日	1994-08-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Role of methionine 230 in intramolecular electron transfer between the oxyferryl heme and tryptophan 191 in cytochrome c peroxidase compound II. Biochemistry, 33, 1994

1BHQ

MAC-1 I DOMAIN CADMIUM COMPLEX
分子名称:	ACETYL GROUP, CADMIUM ION, CD11B
著者	Baldwin, E.T.
登録日	1998-06-10
公開日	1998-11-04
最終更新日	2023-08-02
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Cation binding to the integrin CD11b I domain and activation model assessment Structure, 6, 1998

1BHO

MAC-1 I DOMAIN MAGNESIUM COMPLEX
分子名称:	CD11B, MAGNESIUM ION
著者	Baldwin, E.T.
登録日	1998-06-10
公開日	1998-11-04
最終更新日	2023-08-02
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Cation binding to the integrin CD11b I domain and activation model assessment Structure, 6, 1998

1O76

CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA
分子名称:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, CYANIDE ION, ...
著者	Fedorov, R, Ghosh, D, Schlichting, I.
登録日	2002-10-23
公開日	2002-12-19
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal Structures of Cyanide Complexes of P450Cam and the Oxygenase Domain of Inducible Nitric Oxide Synthase-Structural Models of the Short-Lived Oxygen Complexes Arch.Biochem.Biophys., 409, 2003

2Q1L

Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors
分子名称:	(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
著者	Pavlovsky, A, Pfefferkorn, J.A, Harris, M.S, Finzel, B.C.
登録日	2007-05-24
公開日	2007-07-17
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17, 2007

1NOO

CYTOCHROME P450-CAM COMPLEXED WITH 5-EXO-HYDROXYCAMPHOR
分子名称:	5-EXO-HYDROXYCAMPHOR, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE
著者	Li, H.Y, Poulos, T.L.
登録日	1995-12-02
公開日	1996-03-08
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Crystal Structure of Cytochrome P450-Cam Complexed with its Catalytic Product, 5-Exo-Hydroxycamphor J.Am.Chem.Soc., 117, 1995

2PHB

An Orally Efficacious Factor Xa Inhibitor
分子名称:	(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE, CALCIUM ION, Coagulation factor X, ...
著者	Zhang, E, Kohrt, J.T, Bigge, C.F, Finzel, B.C.
登録日	2007-04-10
公開日	2008-03-25
最終更新日	2017-10-18
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor Chem.Biol.Drug Des., 70, 2007

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