6VYA
| Crystal structure of NotF in complex with brevianamide F and DMSPP | 分子名称: | (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Deoxybrevianamide E synthase notF | 著者 | Dan, Q, Smith, J.L. | 登録日 | 2020-02-25 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc., 144, 2022
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6VY9
| Crystal structure of NotF prenyltransferase | 分子名称: | Deoxybrevianamide E synthase notF | 著者 | Dan, Q, Smith, J.L. | 登録日 | 2020-02-25 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc., 144, 2022
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6WER
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3NNM
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6WEQ
| DENV1 NS1 in complex with neutralizing 2B7 Fab fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B7 Fab fragment heavy chain, 2B7 Fab fragment light chain, ... | 著者 | Akey, D.L, Smith, J.L. | 登録日 | 2020-04-02 | 公開日 | 2020-12-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science, 371, 2021
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3NNJ
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6AL6
| Crystal structure HpiC1 in P42 space group | 分子名称: | 12-epi-hapalindole C/U synthase, CALCIUM ION | 著者 | Newmister, S.A, Li, S, Garcia-Borras, M, Sanders, J.N, Yang, S, Lowell, A.N, Yu, F, Smith, J.L, Williams, R.M, Houk, K.N, Sherman, D.H. | 登録日 | 2017-08-07 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.088 Å) | 主引用文献 | Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. Nat. Chem. Biol., 14, 2018
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6AL8
| Crystal structure HpiC1 Y101F/F138S | 分子名称: | 1,2-ETHANEDIOL, 12-epi-hapalindole C/U synthase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Newmister, S.A, Li, S, Garcia-Borras, M, Sanders, J.N, Yang, S, Lowell, A.N, Yu, F, Smith, J.L, Williams, R.M, Houk, K.N, Sherman, D.H. | 登録日 | 2017-08-07 | 公開日 | 2018-03-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.641 Å) | 主引用文献 | Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. Nat. Chem. Biol., 14, 2018
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2REE
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6BEV
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6B3A
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6B3B
| AprA Methyltransferase 1 - GNAT in complex with Mn2+ , SAM, and Malonate | 分子名称: | AprA Methyltransferase 1, GLYCEROL, MALONATE ION, ... | 著者 | Skiba, M.A, Smith, J.L. | 登録日 | 2017-09-21 | 公開日 | 2017-11-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem. Biol., 12, 2017
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6B39
| AprA Methyltransferase 1 - GNAT in complex with SAH | 分子名称: | AprA Methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION | 著者 | Skiba, M.A, Smith, J.L. | 登録日 | 2017-09-21 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.392 Å) | 主引用文献 | A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem. Biol., 12, 2017
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5DOV
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5DOZ
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6D5X
| Structure of Human ATP:Cobalamin Adenosyltransferase bound to ATP, Adenosylcobalamin, and Triphosphate | 分子名称: | 5'-DEOXYADENOSINE, ADENOSINE-5'-TRIPHOSPHATE, COBALAMIN, ... | 著者 | Dodge, G.J, Campanello, G, Smith, J.L, Banerjee, R. | 登録日 | 2018-04-19 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Sacrificial Cobalt-Carbon Bond Homolysis in Coenzyme B12as a Cofactor Conservation Strategy. J. Am. Chem. Soc., 140, 2018
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6D6Y
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5DP1
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5DP2
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6D5K
| Structure of Human ATP:Cobalamin Adenosyltransferase bound to ATP, and Adenosylcobalamin | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-DEOXYADENOSINE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Dodge, G.J, Campanello, G, Smith, J.L, Banerjee, R. | 登録日 | 2018-04-19 | 公開日 | 2018-10-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Sacrificial Cobalt-Carbon Bond Homolysis in Coenzyme B12as a Cofactor Conservation Strategy. J. Am. Chem. Soc., 140, 2018
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6PVG
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6PVI
| Crystal structure of PhqK in complex with paraherquamide L | 分子名称: | (8aS,13S,13aR,14aS)-4,4,13,15,15-pentamethyl-12,13,14,14a,15,16-hexahydro-4H,8H,9H,11H-8a,13a-(epiminomethano)[1,4]dioxepino[2,3-a]indolizino[6,7-h]carbazol-17-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Fraley, A.E, Smith, J.L, Sherman, D.H. | 登録日 | 2019-07-20 | 公開日 | 2020-01-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.093 Å) | 主引用文献 | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVF
| Crystal structure of PhqK in complex with malbrancheamide B | 分子名称: | (5aS,12aS,13aS)-9-chloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Fraley, A.E, Smith, J.L, Sherman, D.H. | 登録日 | 2019-07-20 | 公開日 | 2020-01-22 | 最終更新日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVH
| Crystal structure of PhqK in complex with paraherquamide K | 分子名称: | (7aS,12S,12aR,13aS)-3,3,12,14,14-pentamethyl-3,7,11,12,13,13a,14,15-octahydro-8H,10H-7a,12a-(epiminomethano)indolizino[6,7-h]pyrano[3,2-a]carbazol-16-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Fraley, A.E, Smith, J.L, Sherman, D.H. | 登録日 | 2019-07-20 | 公開日 | 2020-01-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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6PVJ
| Crystal structure of PhqK in complex with malbrancheamide C | 分子名称: | (5aS,12aS,13aS)-9-bromo-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, FAD monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Fraley, A.E, Smith, J.L, Sherman, D.H. | 登録日 | 2019-07-20 | 公開日 | 2020-01-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway. J.Am.Chem.Soc., 142, 2020
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