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4KUC
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BU of 4kuc by Molmil
Crystal structure of ricin-A chain in complex with the antibody 6C2
分子名称: Ricin, mAb6c2 fab-Heavy chain, mAb6c2 fab-Light chain
著者Zhu, Y, Li, X, Teng, M.
登録日2013-05-21
公開日2013-07-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.787 Å)
主引用文献Structural insights into the neutralization mechanism of mAb 6C2 against ricin
To be Published
3RKZ
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BU of 3rkz by Molmil
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model.
分子名称: (5R,6S)-3-(L-alanyl)-5,6,15,15,18-pentamethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-12,8-(metheno)[1,5,9]triazacyclotetradecino[1,2-a]indole-9-carboxamide, Heat shock protein HSP 90-alpha
著者Zapf, C.W, Bloom, J.D, Li, Z, Dushin, R.G, Nittoli, T, Otteng, M, Nikitenko, A, Golas, J.M, Liu, H, Lucas, J, Boschelli, F, Vogan, E, Olland, A, Johnson, M, Levin, J.I.
登録日2011-04-18
公開日2011-07-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5693 Å)
主引用文献Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Bioorg.Med.Chem.Lett., 21, 2011
3R91
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BU of 3r91 by Molmil
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
分子名称: (6S)-4,6,15,15,18-pentamethyl-5,17-dioxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-12,8-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide, Heat shock protein HSP 90-alpha
著者Zapf, C.W, Bloom, J.D, McBean, J.L, Dushin, R.G, Nittoli, T, Otteng, M, Ingalls, C, Golas, J.M, Liu, H, Lucas, J, Boschelli, F, Vogan, E, Hu, Y, Levin, J.I.
登録日2011-03-24
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.579 Å)
主引用文献Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
Bioorg.Med.Chem.Lett., 21, 2011
4HWO
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BU of 4hwo by Molmil
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
分子名称: N-{[3-(4-aminoquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION
著者Hilgers, M.T.
登録日2012-11-08
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.907 Å)
主引用文献Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J.Med.Chem., 56, 2013
4HWR
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BU of 4hwr by Molmil
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
分子名称: N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION
著者Hilgers, M.T.
登録日2012-11-08
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J.Med.Chem., 56, 2013
4HWS
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BU of 4hws by Molmil
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
分子名称: N-{[3-(4-amino-2-chloroquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION
著者Hilgers, M.T.
登録日2012-11-08
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J.Med.Chem., 56, 2013
4HWP
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BU of 4hwp by Molmil
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
分子名称: N-{[3-(4-amino-2-methylquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION
著者Hilgers, M.T.
登録日2012-11-08
公開日2013-09-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.807 Å)
主引用文献Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J.Med.Chem., 56, 2013
4HWT
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BU of 4hwt by Molmil
Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor
分子名称: N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, cytoplasmic, ...
著者Hilgers, M.T.
登録日2012-11-08
公開日2013-09-18
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J.Med.Chem., 56, 2013
4YLY
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BU of 4yly by Molmil
Crystal structure of peptidyl-tRNA hydrolase from a Gram-positive bacterium, staphylococcus aureus at 2.25 angstrom resolution
分子名称: GLYCEROL, Peptidyl-tRNA hydrolase
著者Zhang, F, Song, Y, Li, X, Teng, M.K.
登録日2015-03-06
公開日2016-01-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 angstrom resolution.
Acta Biochim.Biophys.Sin., 47, 2015
1XX5
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BU of 1xx5 by Molmil
Crystal Structure of Natrin from Naja atra snake venom
分子名称: ETHANOL, Natrin 1
著者Wang, J, Shen, B, Lou, X.H, Guo, M, Teng, M.K, Niu, L.W.
登録日2004-11-04
公開日2005-06-14
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel
Biochemistry, 44, 2005
6LH8
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BU of 6lh8 by Molmil
Structure of aerolysin-like protein (Bombina maxima)
分子名称: aerolysin-like protein
著者Bian, X.L, Wang, Q.Q, Li, X, Teng, M.Q, Zhang, Y.
登録日2019-12-07
公開日2020-06-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.729 Å)
主引用文献A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions.
J.Biol.Chem., 295, 2020
6LHZ
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BU of 6lhz by Molmil
Structure of aerolysin-like protein (Bombina maxima)
分子名称: aerolysin-like protein
著者Bian, X.L, Wang, Q.Q, Li, X, Teng, M.Q, Zhang, Y.
登録日2019-12-10
公開日2020-06-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions.
J.Biol.Chem., 295, 2020
1NFD
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BU of 1nfd by Molmil
AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, H57 FAB, N15 ALPHA-BETA T-CELL RECEPTOR
著者Wang, J.-H, Lim, K, Smolyar, A, Teng, M.-K, Sacchittini, J, Reinherz, E.L.
登録日1997-08-04
公開日1998-01-28
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.
EMBO J., 17, 1998
3HDB
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BU of 3hdb by Molmil
Crystal structure of AaHIV, A metalloproteinase from venom of Agkistrodon Acutus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AAHIV, CALCIUM ION, ...
著者Zhu, Z.Q, Niu, L.W, Teng, M.K.
登録日2009-05-07
公開日2009-08-11
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structural basis of the autolysis of AaHIV suggests a novel target recognizing model for ADAM/reprolysin family proteins
Biochem.Biophys.Res.Commun., 386, 2009
3DXZ
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BU of 3dxz by Molmil
Crystal structure of EcTrmB in complex with SAH
分子名称: 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
著者Zhou, H.H, Liu, Q, Gao, Y.X, Teng, M.K, Niu, L.W.
登録日2008-07-25
公開日2009-05-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
Proteins, 76, 2009
3DXY
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BU of 3dxy by Molmil
Crystal structure of EcTrmB in complex with SAM
分子名称: GLYCEROL, S-ADENOSYLMETHIONINE, SULFATE ION, ...
著者Zhou, H.H, Liu, Q, Gao, Y.X, Teng, M.K, Niu, L.W.
登録日2008-07-25
公開日2009-05-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
Proteins, 76, 2009
3E17
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BU of 3e17 by Molmil
Crystal structure of the second PDZ domain from human Zona Occludens-2
分子名称: Tight junction protein ZO-2
著者Chen, H, Tong, S.L, Teng, M.K, Niu, L.W.
登録日2008-08-01
公開日2009-07-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the second PDZ domain from human zonula occludens 2
Acta Crystallogr.,Sect.F, 65, 2009
3DXX
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BU of 3dxx by Molmil
Crystal structure of EcTrmB
分子名称: GLYCEROL, tRNA (guanine-N(7)-)-methyltransferase
著者Zhou, H.H, Liu, Q, Gao, Y.X, Teng, M.K, Niu, L.W.
登録日2008-07-25
公開日2009-05-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
Proteins, 76, 2009
3B9C
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BU of 3b9c by Molmil
Crystal Structure of Human GRP CRD
分子名称: BETA-MERCAPTOETHANOL, HSPC159, SULFATE ION
著者Zhou, D, Ge, H.H, Niu, L.W, Teng, M.K.
登録日2007-11-05
公開日2008-03-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins.
Proteins, 71, 2008
6LKG
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BU of 6lkg by Molmil
two-component system protein mediate signal transduction
分子名称: 6-O-phosphono-alpha-D-glucopyranose, ABC transporter, solute-binding protein, ...
著者Wang, M, Tao, Y.
登録日2019-12-19
公開日2020-12-02
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.948 Å)
主引用文献Interface switch mediates signal transmission in a two-component system.
Proc.Natl.Acad.Sci.USA, 117, 2020
6LKK
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BU of 6lkk by Molmil
Two-component system protein mediate signal transduction
分子名称: 6-O-phosphono-alpha-D-glucopyranose, ABC transporter, solute-binding protein
著者Wang, M, Tao, Y.
登録日2019-12-19
公開日2020-12-02
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.502 Å)
主引用文献Interface switch mediates signal transmission in a two-component system.
Proc.Natl.Acad.Sci.USA, 117, 2020
4LFI
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BU of 4lfi by Molmil
Crystal structure of scCK2 alpha in complex with GMPPNP
分子名称: Casein kinase II subunit alpha, GLYCEROL, MANGANESE (II) ION, ...
著者Liu, H.
登録日2013-06-27
公開日2014-03-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
8G46
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BU of 8g46 by Molmil
Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2
分子名称: Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DET1- and DDB1-associated protein 1, ...
著者Ma, M.W, Hunkeler, M, Jin, C.Y, Fischer, E.S.
登録日2023-02-08
公開日2023-03-08
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Biorxiv, 2023
8VF6
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BU of 8vf6 by Molmil
Crystal structure of Serine/threonine-protein kinase 33 (STK33) Kinase Domain in complex with inhibitor CDD-2211
分子名称: Serine/threonine-protein kinase 33, {3-[([1,1'-biphenyl]-2-yl)ethynyl]-1H-indazol-5-yl}[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methanone
著者Ta, H.M, Kim, C, Ku, K.A, Matzuk, M.M.
登録日2023-12-21
公開日2024-06-05
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Science, 384, 2024
2B1M
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BU of 2b1m by Molmil
Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus
分子名称: DI(HYDROXYETHYL)ETHER, SPE31, TETRAETHYLENE GLYCOL, ...
著者Zhang, M, Wei, Z, Chang, S.
登録日2005-09-16
公開日2006-10-03
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a papain-fold protein without the catalytic residue: a novel member in the cysteine proteinase family
J.Mol.Biol., 358, 2006

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