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Manganese-dependent transcriptional repressor DR2539 complexed with cadmium (SAD 7 keV)
分子名称:	CADMIUM ION, Iron dependent repressor, putative
著者	Mota, C, De Sanctis, D.
登録日	2023-07-18
公開日	2024-05-08
最終更新日	2024-08-14
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539. Febs J., 291, 2024

8PO2

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFRinsNPG [V948R]
分子名称:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.28 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PTI

CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR
分子名称:	BOVINE PANCREATIC TRYPSIN INHIBITOR
著者	Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A.
登録日	1990-12-17
公開日	1991-04-15
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor. J.Mol.Biol., 220, 1991

8PO0

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG
分子名称:	1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.523 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PQX

p97 (VCP) mutant - F539A state III
分子名称:	ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Transitional endoplasmic reticulum ATPase
著者	Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A.
登録日	2023-07-12
公開日	2024-05-29
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	p97 (VCP) mutant - F539A state III To Be Published

7BOM

Crystal structure of recombinant horse spleen apo-R52C/E56C/R59C/E63C-Fr immobilized with gold ions.
分子名称:	1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ...
著者	Hishikawa, Y, Maity, B, Ito, N, Abe, S, Lu, D, Ueno, T.
登録日	2020-03-19
公開日	2021-01-27
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	Design of Multinuclear Gold Binding Site at the Two-fold Symmetric Interface of the Ferritin Cage Chem Lett., 49, 2021

8D04

Hallucinated C2 protein assembly HALC2_062
分子名称:	HALC2_062
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.11 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

8D07

Hallucinated C3 protein assembly HALC3_109
分子名称:	HALC3_109
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.09 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

7BX7

Cryo-EM structure of amyloid fibril formed by hnRNPA1 low complexity domain
分子名称:	Heterogeneous nuclear ribonucleoprotein A1
著者	Sun, Y.P, Zhao, K, Liu, C, Li, D.
登録日	2020-04-17
公開日	2020-11-18
最終更新日	2024-03-27
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure. Nat Commun, 11, 2020

8PO3

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R]
分子名称:	2-methyl-5-[[3-[1-[(3~{S})-1-propanoylpyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.13 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8D05

Hallucinated C2 protein assembly HALC2_065
分子名称:	HALC2_065
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.51 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

8PO1

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 22 bound to EGFRinsNPG [V948R]
分子名称:	2-methyl-5-[[3-[1-[(3~{S},5~{R})-5-methyl-1-propanoyl-pyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor, IODIDE ION
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.11 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO4

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R]
分子名称:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Epidermal growth factor receptor, ...
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.621 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

7C1L

Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant R148A in complex with C8-CoA
分子名称:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Non-ribosomal peptide synthetase modules, OCTANOYL-COENZYME A
著者	Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X.
登録日	2020-05-05
公開日	2020-11-25
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. Nat Commun, 12, 2021

8D08

Hallucinated C4 protein assembly HALC4_135
分子名称:	HALC4_135
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

7C1U

Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant H140V/R148A in a "product-released" conformation
分子名称:	Non-ribosomal peptide synthetase modules
著者	Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X.
登録日	2020-05-05
公開日	2020-11-25
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. Nat Commun, 12, 2021

8PEW

Rho-ATPgS-Psu complex II
分子名称:	MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Polarity suppression protein, ...
著者	Gjorgjevikj, D, Wahl, M.C, Hilal, T, Loll, B.
登録日	2023-06-15
公開日	2024-06-26
実験手法	ELECTRON MICROSCOPY (4.3 Å)
主引用文献	Rho-ATPgS-Psu complex II To Be Published

8PNZ

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR
分子名称:	1-[(3~{S})-3-[4-(6,7-dimethoxyquinazolin-4-yl)-3-(3-methoxyphenyl)pyrazol-1-yl]pyrrolidin-1-yl]propan-1-one, Epidermal growth factor receptor
著者	Hargreaves, D.
登録日	2023-07-03
公開日	2024-06-05
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (2.51 Å)
主引用文献	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8D03

Hallucinated C2 protein assembly HALC2_068
分子名称:	HALC2_068
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

8PEL

Structure of C. thermophilum RNA exosome core
分子名称:	Exoribonuclease phosphorolytic domain-containing protein, Exoribonuclease-like protein, Exosome complex component MTR3, ...
著者	Lazzaretti, D, Holdermann, I, Sprangers, R.
登録日	2023-06-14
公開日	2024-06-26
実験手法	X-RAY DIFFRACTION (3.81 Å)
主引用文献	Beyond static structures: quantitative dynamics in the eukaryotic RNA exosome complex Biorxiv, 2024

8D09

Hallucinated C4 protein assembly HALC4_136
分子名称:	HALC4_136
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

8PFR

Mouse RPL39L integrated into the yeast 60S ribosomal subunit
分子名称:	25S rRNA, 5.8S rRNA, 5S rRNA, ...
著者	Rabl, J, Banerjee, A, Boehringer, D, Zavolan, M.
登録日	2023-06-16
公開日	2024-06-26
実験手法	ELECTRON MICROSCOPY (2.15 Å)
主引用文献	Mouse RPL39L integrated into the yeast 60S ribosomal subunit To Be Published

8D06

Hallucinated C3 protein assembly HALC3_104
分子名称:	HALC3_104
著者	Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日	2022-05-25
公開日	2022-09-28
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (3.4 Å)
主引用文献	Hallucinating symmetric protein assemblies. Science, 378, 2022

8PEX

Rho P167L-ATPgS-Psu complex I
分子名称:	MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Polarity suppression protein, ...
著者	Gjorgjevikj, D, Wahl, M.C, Hilal, T, Loll, B.
登録日	2023-06-15
公開日	2024-06-26
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Rho P167L-ATPgS-Psu complex I To Be Published

7C1H

Crystal structure of the starter condensation domain of rhizomide synthetase RzmA
分子名称:	Non-ribosomal peptide synthetase modules
著者	Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X.
登録日	2020-05-04
公開日	2020-11-25
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. Nat Commun, 12, 2021

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表示件数:	25
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