6PZB
 
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6PZI
 | | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP only | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8 | | 著者 | Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W. | | 登録日 | 2019-07-31 | | 公開日 | 2019-08-14 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
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6PZA
 | | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide | | 分子名称: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | 著者 | Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W. | | 登録日 | 2019-07-31 | | 公開日 | 2019-08-14 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
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6PZ9
 | | Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and repaglinide | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11, ... | | 著者 | Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W. | | 登録日 | 2019-07-31 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
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6PZC
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5KK2
 | | Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy | | 分子名称: | Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | | 著者 | Zhao, Y, Chen, S, Yoshioka, C, Baconguis, I, Gouaux, E. | | 登録日 | 2016-06-20 | | 公開日 | 2016-07-06 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | | 主引用文献 | Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.
Nature, 536, 2016
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6DW1
 | | Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-06-26 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA.
Elife, 7, 2018
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6DW0
 | | Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (Whole map) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-06-26 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA.
Elife, 7, 2018
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3J7T
 | | Calcium atpase structure with two bound calcium ions determined by electron crystallography of thin 3D crystals | | 分子名称: | CALCIUM ION, SODIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | | 著者 | Yonekura, K, Kato, K, Ogasawara, M, Tomita, M, Toyoshima, C. | | 登録日 | 2014-08-07 | | 公開日 | 2015-02-18 | | 最終更新日 | 2016-09-28 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3.4 Å) | | 主引用文献 | Electron crystallography of ultrathin 3D protein crystals: atomic model with charges
Proc.Natl.Acad.Sci.USA, 112, 2015
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1IS3
 | | LACTOSE AND MES-LIGANDED CONGERIN II | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CONGERIN II, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Shirai, T, Matsui, Y, Shionyu-Mitsuyama, C, Yamane, T, Kamiya, H, Ishii, C, Ogawa, T, Muramoto, K. | | 登録日 | 2001-11-12 | | 公開日 | 2002-09-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal structure of a conger eel galectin (congerin II) at 1.45 A resolution: Implication for the accelerated evolution of a new ligand-binding site following gene duplication
J.MOL.BIOL., 321, 2002
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1IS5
 | | Ligand free Congerin II | | 分子名称: | Congerin II | | 著者 | Shirai, T, Matsui, Y, Shionyu-Mitsuyama, C, Yamane, T, Kamiya, H, Ishii, C, Ogawa, T, Muramoto, K. | | 登録日 | 2001-11-12 | | 公開日 | 2002-09-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of a conger eel galectin (congerin II) at 1.45 A resolution: Implication for the accelerated evolution of a new ligand-binding site following gene duplication
J.MOL.BIOL., 321, 2002
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1IS4
 | | LACTOSE-LIGANDED CONGERIN II | | 分子名称: | CONGERIN II, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Shirai, T, Matsui, Y, Shionyu-Mitsuyama, C, Yamane, T, Kamiya, H, Ishii, C, Ogawa, T, Muramoto, K. | | 登録日 | 2001-11-12 | | 公開日 | 2002-09-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of a Conger Eel Galectin (Congerin II) at 1.45 A Resolution: Implication for the Accelerated Evolution of a New Ligand-Binding Site Following Gene Duplication
J.Mol.Biol., 321, 2002
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1IS6
 | | MES-Liganded Congerin II | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Congerin II | | 著者 | Shirai, T, Matsui, Y, Shionyu-Mitsuyama, C, Yamane, T, Kamiya, H, Ishii, C, Ogawa, T, Muramoto, K. | | 登録日 | 2001-11-12 | | 公開日 | 2002-09-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of a conger eel galectin (congerin II) at 1.45 A resolution: Implication for the accelerated evolution of a new ligand-binding site following gene duplication
J.MOL.BIOL., 321, 2002
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4YCM
 | | Crystal structure of the calcium pump with bound marine macrolide BLS | | 分子名称: | (4S,5E,8S,9E,11S,13E,15E,18R)-8-methoxy-9,11-dimethyl-18-[(1Z,4E)-2-methylhexa-1,4-dien-1-yl]-2-oxooxacyclooctadeca-5,9,13,15-tetraen-4-yl 3-O-methyl-beta-D-glucopyranoside, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | | 著者 | Morita, M, Ogawa, H, Ohno, O, Yamori, T, Suenaga, K, Toyoshima, C. | | 登録日 | 2015-02-20 | | 公開日 | 2016-01-13 | | 最終更新日 | 2020-02-05 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding
Febs Lett., 589, 2015
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5AVR
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 1.5 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AVZ
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 55 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AVU
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 7.0 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AW2
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 85 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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4YCN
 | | Crystal structure of the calcium pump with bound marine macrolide BLLB | | 分子名称: | (4S,5E,8S,9E,11S,13E,15E,18R)-4-hydroxy-8-methoxy-9,11-dimethyl-18-[(1Z,4E)-2-methylhexa-1,4-dien-1-yl]oxacyclooctadeca-5,9,13,15-tetraen-2-one, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | | 著者 | Morita, M, Ogawa, H, Ohno, O, Yamori, T, Suenaga, K, Toyoshima, C. | | 登録日 | 2015-02-20 | | 公開日 | 2016-01-13 | | 最終更新日 | 2020-02-05 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding
Febs Lett., 589, 2015
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5AW0
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 55 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AW6
 | | Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 5.5 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AVX
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 20 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AVV
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 8.5 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AW5
 | | Kinetics by X-ray crystallography: Rb+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 2.2 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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5AVW
 | | Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 16.5 min | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Ogawa, H, Cornelius, F, Hirata, A, Toyoshima, C. | | 登録日 | 2015-07-01 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6, 2015
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