7AQE
 
 | | Structure of SARS-CoV-2 Main Protease bound to UNC-2327 | | 分子名称: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Guenther, S, Reinke, P, Meents, A. | | 登録日 | 2020-10-21 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Science, 372, 2021
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6Z9U
 | | Crystal structure of a TSEN15-34 heterodimer. | | 分子名称: | GLYCEROL, tRNA-splicing endonuclease subunit Sen15, tRNA-splicing endonuclease subunit Sen34 | | 著者 | Trowitzsch, S, Sekulovski, S. | | 登録日 | 2020-06-04 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.10001779 Å) | | 主引用文献 | Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Nat Commun, 12, 2021
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8S85
 | | Crystal structure of JAK1 JH1 domain in complex with an inhibitor | | 分子名称: | SODIUM ION, Tyrosine-protein kinase JAK1, ~{N}-(2-ethylphenyl)-~{N},1-dimethyl-imidazo[4,5-c]pyridin-6-amine | | 著者 | Flower, T.F, Lopez-Ramos, M, Geney, R, Jestel, A. | | 登録日 | 2024-03-05 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Design of a potent and selective dual JAK1/TYK2 inhibitor.
Bioorg.Med.Chem., 114, 2024
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7Z3K
 | | Autotaxin in complex with orthosteric site-binder CpdA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | 著者 | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | | 登録日 | 2022-03-02 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Autotaxin facilitates selective LPA receptor signaling.
Cell Chem Biol, 30, 2023
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7Z3L
 | | Autotaxin in complex with hybrid compound ziritaxestat (GLPG1690) | | 分子名称: | 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A. | | 登録日 | 2022-03-02 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Autotaxin facilitates selective LPA receptor signaling.
Cell Chem Biol, 30, 2023
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