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Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
分子名称:	N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide, Protein-tyrosine kinase 2-beta
著者	Newby, Z.E.
登録日	2016-10-17
公開日	2017-11-29
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.117 Å)
主引用文献	Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency. Bioorg. Med. Chem. Lett., 26, 2016

PI3Kdelta in complex with the inhibitor GS-643624
分子名称:	2,4-bis(azanyl)-6-[[(1~{S})-1-[5-chloranyl-3-(5-fluoranyl-4-methyl-pyridin-3-yl)-4-oxidanylidene-quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者	Somoza, J.R, Villasenor, A.
登録日	2016-09-04
公開日	2016-12-28
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd To Be Published

PI3Kdelta in complex with the inhibitor GS-9901
分子名称:	2,4-diamino-6-{[(S)-[5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl](cyclopropyl)methyl]amino}pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者	Somoza, J.R, Villasenor, A.
登録日	2016-09-07
公開日	2016-12-28
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd To Be Published