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2F9I
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BU of 2f9i by Molmil
Crystal Structure of the carboxyltransferase subunit of ACC from Staphylococcus aureus
分子名称: ZINC ION, acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
著者Bilder, P.W.
登録日2005-12-05
公開日2006-12-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.
Biochemistry, 45, 2006
3V5Q
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BU of 3v5q by Molmil
Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models
分子名称: 1-(3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea, CHLORIDE ION, NT-3 growth factor receptor
著者Kreusch, A.
登録日2011-12-16
公開日2012-02-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2001 Å)
主引用文献Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
ACS Med Chem Lett, 3, 2012
2WGC
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BU of 2wgc by Molmil
2.2 ANGSTROMS RESOLUTION STRUCTURE ANALYSIS OF TWO REFINED N-ACETYLNEURAMINYLLACTOSE-WHEAT GERM AGGLUTININ ISOLECTIN COMPLEXES
分子名称: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, WHEAT GERM LECTIN
著者Wright, C.S.
登録日1990-04-03
公開日1990-10-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献2.2 A resolution structure analysis of two refined N-acetylneuraminyl-lactose--wheat germ agglutinin isolectin complexes.
J.Mol.Biol., 215, 1990
3WAJ
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BU of 3waj by Molmil
Crystal structure of the Archaeoglobus fulgidus oligosaccharyltransferase (O29867_ARCFU) complex with Zn and sulfate
分子名称: SULFATE ION, Transmembrane oligosaccharyl transferase, ZINC ION
著者Matsumoto, S, Shimada, A, Kohda, D.
登録日2013-05-03
公開日2013-10-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation
Proc.Natl.Acad.Sci.USA, 110, 2013
3WAK
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BU of 3wak by Molmil
Crystal structure of the Archaeoglobus fulgidus oligosaccharyltransferase (O29867_ARCFU) in the apo form
分子名称: MANGANESE (II) ION, Transmembrane oligosaccharyl transferase
著者Matsumoto, S, Shimada, A, Kohda, D.
登録日2013-05-03
公開日2013-10-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.413 Å)
主引用文献Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation
Proc.Natl.Acad.Sci.USA, 110, 2013
7FSA
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BU of 7fsa by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 24
分子名称: (1M)-6-[4-(3-aminobenzene-1-sulfonyl)piperazine-1-sulfonyl][1,1'-biphenyl]-3,3',4,4'-tetrol, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.909 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS1
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BU of 7fs1 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 11
分子名称: (1P)-N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-3',4,4',5-tetrahydroxy[1,1'-biphenyl]-2-sulfonamide, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.863 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS0
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BU of 7fs0 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 8
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 3,4-dihydroxy-N-{2-[4-(3-hydroxybenzene-1-sulfonyl)phenyl]ethyl}benzene-1-sulfonamide, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.412 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS5
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BU of 7fs5 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 17
分子名称: (10aP)-6-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-2,3,8,9-tetrahydroxy-5lambda~6~-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.182 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS3
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BU of 7fs3 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 15
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-4,4',5-trihydroxy[1,1'-biphenyl]-2-sulfonamide, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.655 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FRV
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BU of 7frv by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 3
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 4,4'-sulfonyldi(benzene-1,2-diol), MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FRY
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BU of 7fry by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 6
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-{2-[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]ethyl}-3,4-dihydroxybenzene-1-sulfonamide, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.958 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS6
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BU of 7fs6 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 18
分子名称: (10aM)-6-{2-[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]ethyl}-2,3,8,9-tetrahydroxy-5lambda~6~-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.241 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FSB
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BU of 7fsb by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 41
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)-3,4-dihydroxybenzene-1-sulfonamide, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS7
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BU of 7fs7 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 20
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-N-(3,4-dihydroxyphenyl)-3,4-dihydroxybenzene-1-sulfonamide, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.774 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FRZ
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BU of 7frz by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 7
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 3,4-dihydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}benzene-1-sulfonamide, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.085 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FRX
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BU of 7frx by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 5
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-3,4-dihydroxybenzene-1-sulfonamide, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.847 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FRW
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Structure of liver pyruvate kinase in complex with allosteric modulator 4
分子名称: (10aM)-3,8,9-trihydroxy-6H-6lambda~6~-dibenzo[c,e][1,2]oxathiine-6,6-dione, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.737 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS4
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BU of 7fs4 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 16
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 4,4',5-trihydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}[1,1'-biphenyl]-2-sulfonamide, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS9
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BU of 7fs9 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 22
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 4-[4-(4-aminobenzene-1-sulfonyl)piperazine-1-sulfonyl]benzene-1,2-diol, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.721 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FSD
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BU of 7fsd by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 44
分子名称: (1M)-N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)-3',4,4',5-tetrahydroxy[1,1'-biphenyl]-2-sulfonamide, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.769 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS2
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BU of 7fs2 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 13
分子名称: (1P)-3',4,4',5-tetrahydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}[1,1'-biphenyl]-2-sulfonamide, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.374 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FS8
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BU of 7fs8 by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 21
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 4-[4-(3-aminobenzene-1-sulfonyl)piperazine-1-sulfonyl]benzene-1,2-diol, MAGNESIUM ION, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
7FSC
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BU of 7fsc by Molmil
Structure of liver pyruvate kinase in complex with allosteric modulator 42
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)benzenesulfonamide, ...
著者Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M.
登録日2022-12-18
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.855 Å)
主引用文献Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
2LTH
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BU of 2lth by Molmil
NMR structure of major ampullate spidroin 1 N-terminal domain at pH 5.5
分子名称: Major ampullate spidroin 1
著者Otikovs, M, Jaudzems, K, Nordling, K, Landreh, M, Rising, A, Askarieh, G, Knight, S, Johansson, J.
登録日2012-05-25
公開日2013-11-27
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.
Nat Commun, 5, 2014

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