8S01
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s01 by Molmil](/molmil-images/mine/8s01) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-(4-chlorophenyl)-1H-pyrazole, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8S0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s0o by Molmil](/molmil-images/mine/8s0o) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-[4-chloranyl-2-(1H-pyrazol-4-ylmethyl)indazol-5-yl]-5-methyl-6-(piperazin-1-ylmethyl)-1H-pyrrolo[3,2-b]pyridine, FORMIC ACID, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.834 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8S07
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s07 by Molmil](/molmil-images/mine/8s07) | A fragment-based inhibitor of SHP2 | 分子名称: | 7-azanyl-N-pyridin-3-yl-3H-pyrrolo[3,2-b]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8S0I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s0i by Molmil](/molmil-images/mine/8s0i) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-phenyl-1H-pyrrolo[3,2-b]pyridine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.929 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8S0Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s0q by Molmil](/molmil-images/mine/8s0q) | A fragment-based inhibitor of SHP2 | 分子名称: | (1S,5R)-8-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]-8-azabicyclo[3.2.1]octan-3-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.872 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8RZY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rzy by Molmil](/molmil-images/mine/8rzy) | A fragment-based inhibitor of SHP2 | 分子名称: | 1H-pyrrolo[3,2-b]pyridin-5-amine, DIMETHYL SULFOXIDE, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8S0H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s0h by Molmil](/molmil-images/mine/8s0h) | A fragment-based inhibitor of SHP2 | 分子名称: | 5-(aminomethyl)-N-(3-chloranyl-1-methyl-indol-7-yl)-1,3-dihydroisoindole-2-sulfonamide, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
8S0J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8s0j by Molmil](/molmil-images/mine/8s0j) | A fragment-based inhibitor of SHP2 | 分子名称: | 3-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]propan-1-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Cleasby, A, Price, A. | 登録日 | 2024-02-14 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
|
|
4XY2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xy2 by Molmil](/molmil-images/mine/4xy2) | Crystal structure of PDE10A in complex with ASP9436 | 分子名称: | 1-methyl-5-(1-methyl-3-{[4-(1-methyl-1H-benzimidazol-4-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Amano, Y, Honbou, K. | 登録日 | 2015-02-02 | 公開日 | 2015-06-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436 Bioorg.Med.Chem., 23, 2015
|
|
3FX5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fx5 by Molmil](/molmil-images/mine/3fx5) | Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by High Resolution X-ray Crystallography | 分子名称: | (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide, GLYCEROL, protease | 著者 | Adachi, M, Ohhara, T, Tamada, T, Okazaki, N, Kuroki, R. | 登録日 | 2009-01-20 | 公開日 | 2009-03-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (0.93 Å) | 主引用文献 | Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography. Proc.Natl.Acad.Sci.USA, 2009
|
|
1QRS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qrs by Molmil](/molmil-images/mine/1qrs) | |
1QRT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qrt by Molmil](/molmil-images/mine/1qrt) | |
1QRU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qru by Molmil](/molmil-images/mine/1qru) | |
2LEV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lev by Molmil](/molmil-images/mine/2lev) | Structure of the DNA complex of the C-Terminal domain of Ler | 分子名称: | DNA (5'-D(*CP*CP*TP*AP*TP*CP*AP*AP*TP*TP*AP*TP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*AP*TP*AP*AP*TP*TP*GP*AP*TP*AP*GP*G)-3'), Ler | 著者 | Cordeiro, T.N, Schimdt, H, Madrid, C, Juarez, A, Bernado, P, Grisienger, C, Garcia, J, Pons, M. | 登録日 | 2011-06-23 | 公開日 | 2011-12-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | 主引用文献 | Indirect DNA Readout by an H-NS Related Protein: Structure of the DNA Complex of the C-Terminal Domain of Ler. Plos Pathog., 7, 2011
|
|
5B0D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b0d by Molmil](/molmil-images/mine/5b0d) | Polyketide cyclase OAC from Cannabis sativa, Y27W mutant | 分子名称: | Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
5B09
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b09 by Molmil](/molmil-images/mine/5b09) | Polyketide cyclase OAC from Cannabis sativa bound with Olivetolic acid | 分子名称: | 2,4-bis(oxidanyl)-6-pentyl-benzoic acid, Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
5B0G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b0g by Molmil](/molmil-images/mine/5b0g) | Polyketide cyclase OAC from Cannabis sativa, H78S mutant | 分子名称: | Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
1IQH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1iqh by Molmil](/molmil-images/mine/1iqh) | Human coagulation factor Xa in complex with M55143 | 分子名称: | 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-07-23 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published
|
|
5B0B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b0b by Molmil](/molmil-images/mine/5b0b) | Polyketide cyclase OAC from Cannabis sativa, I7F mutant | 分子名称: | ACETATE ION, Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.187 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
1IOE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ioe by Molmil](/molmil-images/mine/1ioe) | Human coagulation factor Xa in complex with M55532 | 分子名称: | (-)-7-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]TETRAHYDRO-8A-(METHOXYMETHYL)-1'-(4-PYRIDINYL)-SPIRO[5H-OXAZOLO[3,2-A]PYRAZINE-2(3H),4'-PIPERIDIN]-5-ONE, CALCIUM ION, COAGULATION FACTOR XA | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-03-08 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Factor Xa Specific Inhibitor That Induces the Novel Binding Model In Complex With Human FXa To be Published
|
|
1FQG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fqg by Molmil](/molmil-images/mine/1fqg) | |
5B08
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b08 by Molmil](/molmil-images/mine/5b08) | Polyketide cyclase OAC from Cannabis sativa | 分子名称: | Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.325 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
5B0A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b0a by Molmil](/molmil-images/mine/5b0a) | Polyketide cyclase OAC from Cannabis sativa, H5Q mutant | 分子名称: | Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
5B0E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5b0e by Molmil](/molmil-images/mine/5b0e) | Polyketide cyclase OAC from Cannabis sativa, V59M mutant | 分子名称: | GLYCEROL, Olivetolic acid cyclase | 著者 | Yang, X, Matsui, T, Mori, T, Abe, I, Morita, H. | 登録日 | 2015-10-28 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.603 Å) | 主引用文献 | Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa Febs J., 283, 2016
|
|
8PE9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pe9 by Molmil](/molmil-images/mine/8pe9) | Complex between DDR1 DS-like domain and PRTH-101 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Liu, J, Chiang, H, Xiong, W, Laurent, V, Griffiths, S.C, Duelfer, J, Deng, H, Sun, X, Yin, Y.W, Li, W, Audoly, L.P, An, Z, Schuerpf, T, Li, R, Zhang, N. | 登録日 | 2023-06-13 | 公開日 | 2023-06-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.152 Å) | 主引用文献 | A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer. J Immunother Cancer, 11, 2023
|
|