8C33
 
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8C37
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8C31
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6OMU
 | | Structure of human Bruton's Tyrosine Kinase in complex with Evobrutinib | | 分子名称: | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one, CHLORIDE ION, Tyrosine-protein kinase BTK | | 著者 | Mochalkin, I, Gardberg, A.S. | | 登録日 | 2019-04-19 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
J.Med.Chem., 62, 2019
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6XEW
 | | Structure of Serratia marcescens 2,3-butanediol dehydrogenase | | 分子名称: | 2,3-butanediol dehydrogenase, ADENOSINE-5'-DIPHOSPHATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Alahuhta, P.M, Lunin, V.V. | | 登録日 | 2020-06-14 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Phylogenetics-based identification and characterization of a superior 2,3-butanediol dehydrogenase for Zymomonas mobilis expression.
Biotechnol Biofuels, 13, 2020
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6XEX
 | | Structure of Serratia marcescens 2,3-butanediol dehydrogenase mutant Q247A/V139Q | | 分子名称: | 1,2-ETHANEDIOL, 2,3-butanediol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Alahuhta, P.M, Lunin, V.V. | | 登録日 | 2020-06-14 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Phylogenetics-based identification and characterization of a superior 2,3-butanediol dehydrogenase for Zymomonas mobilis expression.
Biotechnol Biofuels, 13, 2020
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6XWL
 | | Cystathionine beta-synthase from Toxoplasma gondii | | 分子名称: | Cystathionine beta-synthase, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. | | 登録日 | 2020-01-23 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | | 主引用文献 | Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii .
Comput Struct Biotechnol J, 19, 2021
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9EYX
 | | Human PRMT5 in complex with AZ compound 28 | | 分子名称: | (3~{S})-2-[(5-azanyl-6-fluoranyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... | | 著者 | Debreczeni, J. | | 登録日 | 2024-04-09 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 2024
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9EYU
 | | Human PRMT5 in complex with AZ compound 1 | | 分子名称: | (1~{S})-2-[(2-carbamimidamido-1,3-thiazol-5-yl)methyl]-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... | | 著者 | Debreczeni, J. | | 登録日 | 2024-04-09 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 2024
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9EYV
 | | Human PRMT5 in complex with AZ compound 12 | | 分子名称: | (1~{S})-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-2-(1~{H}-pyrrolo[3,2-b]pyridin-2-ylmethyl)-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... | | 著者 | Debreczeni, J. | | 登録日 | 2024-04-09 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 2024
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9EYW
 | | Human PRMT5 in complex with AZ compound 21 | | 分子名称: | (3~{S})-2-[(5-azanyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ... | | 著者 | Debreczeni, J. | | 登録日 | 2024-04-09 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 2024
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8Q0E
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5WXH
 | | Crystal structure of TAF3 PHD finger bound to H3K4me3 | | 分子名称: | Histone H3K4me3, Transcription initiation factor TFIID subunit 3, ZINC ION | | 著者 | Zhao, S, Huang, J, Li, H. | | 登録日 | 2017-01-07 | | 公開日 | 2017-08-16 | | 最終更新日 | 2017-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.297 Å) | | 主引用文献 | Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WXG
 | | Structure of TAF PHD finger domain binds to H3(1-15)K4ac | | 分子名称: | Histone H3K4ac, MAGNESIUM ION, Transcription initiation factor TFIID subunit 3, ... | | 著者 | Zhao, S, Li, H. | | 登録日 | 2017-01-07 | | 公開日 | 2017-08-16 | | 最終更新日 | 2017-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | | 主引用文献 | Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8Q0P
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5X9H
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5X9G
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7YUJ
 | | Crystal structure of HOIL-1L(365-510) | | 分子名称: | DI(HYDROXYETHYL)ETHER, RanBP-type and C3HC4-type zinc finger-containing protein 1, ZINC ION | | 著者 | Xiao, L, Pan, L. | | 登録日 | 2022-08-17 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.865 Å) | | 主引用文献 | Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding.
Sci Adv, 9, 2023
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7YUI
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3ZM7
 | | CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPCP | | 分子名称: | DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | 著者 | Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C. | | 登録日 | 2013-02-05 | | 公開日 | 2013-09-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
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3ZKD
 | | CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP | | 分子名称: | DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C. | | 登録日 | 2013-01-22 | | 公開日 | 2013-09-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
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3ZFZ
 | | Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by soaking | | 分子名称: | CADMIUM ION, CHLORIDE ION, Ceftaroline, ... | | 著者 | Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. | | 登録日 | 2012-12-13 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function
Proc.Natl.Acad.Sci.USA, 110, 2013
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3ZG5
 | | Crystal structure of PBP2a from MRSA in complex with peptidoglycan analogue at allosteric | | 分子名称: | CADMIUM ION, CHLORIDE ION, PEPTIDOGLYCAN ANALOGUE, ... | | 著者 | Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. | | 登録日 | 2012-12-14 | | 公開日 | 2013-10-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function
Proc.Natl.Acad.Sci.USA, 110, 2013
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7DSJ
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7DSM
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