5WYZ
 
 | | Crystal structure of human TLR8 in complex with CU-CPT9b | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2017-01-16 | | 公開日 | 2017-12-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Small-molecule inhibition of TLR8 through stabilization of its resting state
Nat. Chem. Biol., 14, 2018
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5Z14
 | | Crystal structure of human TLR8 in complex with CU-CPT9a | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2017-12-25 | | 公開日 | 2018-07-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State
To Be Published
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5WYX
 | | Crystal structure of human TLR8 in complex with CU-CPT8m | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2017-01-16 | | 公開日 | 2017-12-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Small-molecule inhibition of TLR8 through stabilization of its resting state
Nat. Chem. Biol., 14, 2018
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5YAD
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5YAA
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6KYA
 | | Crystal structure of human TLR8 in complex TH1027 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ... | | 著者 | Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T. | | 登録日 | 2019-09-17 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J.Med.Chem., 63, 2020
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6J7N
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A co-expressed with TakA from Mycobacterium tuberculosis | | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.294 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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6J7S
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis | | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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6J7P
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q co-expressed with TakA from Mycobacterium tuberculosis | | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2020-05-20 | | 実験手法 | X-RAY DIFFRACTION (2.629 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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6J7Q
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A from Mycobacterium tuberculosis | | 分子名称: | CALCIUM ION, MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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6J7O
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q from Mycobacterium tuberculosis | | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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6J7T
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A from Mycobacterium tuberculosis | | 分子名称: | GLYCEROL, MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2020-05-20 | | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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6J7R
 | | Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A co-expressed with TakA from Mycobacterium tuberculosis | | 分子名称: | MAGNESIUM ION, guanylyltransferase-like toxin | | 著者 | Yu, X, Gao, X, Zhu, K, Wojdyla, J.A, Wang, M, Cui, S. | | 登録日 | 2019-01-18 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | | 主引用文献 | Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
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7X08
 | | S protein of SARS-CoV-2 in complex with 2G1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | | 登録日 | 2022-02-21 | | 公開日 | 2022-03-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD.
Cell Discov, 8, 2022
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7WZ7
 | | GPR110/G12 complex | | 分子名称: | Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | He, Y, Zhu, X. | | 登録日 | 2022-02-17 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.
Nat Commun, 13, 2022
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7WY0
 | | GPR110/G13 complex | | 分子名称: | Adhesion G-protein coupled receptor F1, Engineered G alpha 13 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | He, Y, Zhu, X. | | 登録日 | 2022-02-15 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.
Nat Commun, 13, 2022
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7WXU
 | | GPR110/Gq complex | | 分子名称: | Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | He, Y, Zhu, X. | | 登録日 | 2022-02-15 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.
Nat Commun, 13, 2022
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7WXW
 | | GPR110/Gs complex | | 分子名称: | Adhesion G-protein coupled receptor F1, Engineered mini Galpha-s subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | He, Y, Zhu, X. | | 登録日 | 2022-02-15 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.
Nat Commun, 13, 2022
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7X2V
 | | GPR110/Gi complex | | 分子名称: | Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | He, Y, Zhu, X. | | 登録日 | 2022-02-26 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.
Nat Commun, 13, 2022
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7VLM
 | | crystal structure of anti-CRISPR protein AcrIIA18 | | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, H2C7, ... | | 著者 | Zhang, H, Wang, X.S, Li, X.Z. | | 登録日 | 2021-10-04 | | 公開日 | 2021-12-01 | | 最終更新日 | 2023-07-05 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Inhibition mechanisms of CRISPR-Cas9 by AcrIIA17 and AcrIIA18
Nucleic Acids Res., 50, 2022
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7X7R
 | | Cryo-EM structure of a bacterial protein | | 分子名称: | RAMP superfamily protein, RNA (36-MER), RNA (5'-R(P*AP*GP*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ... | | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | | 登録日 | 2022-03-10 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Nat Microbiol, 7, 2022
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7X8A
 | | Cryo-EM structure of a bacterial protein complex | | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | | 登録日 | 2022-03-11 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Nat Microbiol, 7, 2022
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7XC7
 | | Cryo-EM structure of a bacterial protein complex | | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | | 登録日 | 2022-03-23 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Nat Microbiol, 7, 2022
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7X7A
 | | Cryo-EM structure of SbCas7-11 in complex with crRNA and target RNA | | 分子名称: | RAMP superfamily protein, RNA (33-MER), ZINC ION | | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | | 登録日 | 2022-03-09 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Nat Microbiol, 7, 2022
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7WQZ
 | | Structure of Active-mutEP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain | | 著者 | Yang, X.L, Ding, Z.Y, Huang, H.J. | | 登録日 | 2022-01-26 | | 公開日 | 2022-10-26 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase.
Nat Commun, 13, 2022
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