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Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300
分子名称:	Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone
著者	Merritt, E.A, Larson, E.T.
登録日	2011-11-18
公開日	2012-03-14
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.27 Å)
主引用文献	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V51

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176
分子名称:	3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Merritt, E.A, Larson, E.T.
登録日	2011-12-15
公開日	2012-03-14
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V5P

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288
分子名称:	3-(4-methoxy-3-methylphenyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Merritt, E.A, Larson, E.T.
登録日	2011-12-16
公開日	2012-03-14
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

4TZR

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1561
分子名称:	1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-07-10
公開日	2014-08-27
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016

4WG5

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647
分子名称:	5-amino-3-[7-(cyclobutyloxy)quinolin-3-yl]-1-cyclohexyl-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-09-17
公開日	2014-10-15
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647 to be published

4WG3

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610
分子名称:	3-(7-ethoxynaphthalen-2-yl)-1-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-09-17
公開日	2014-10-15
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610 to be published

4WG4

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
分子名称:	3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-09-17
公開日	2014-10-15
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613 to be published

3HGB

Crystal structure of glycine cleavage system protein H from Mycobacterium tuberculosis
分子名称:	Glycine cleavage system H protein
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2009-05-13
公開日	2009-05-26
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. J.Struct.Funct.Genom., 11, 2010

3TK1

Crystal structure of a MeaB and Rv1496 ortholog from Mycobacterium thermoresistible bound to GDP
分子名称:	CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Membrane ATPase/protein kinase
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2011-08-25
公開日	2011-10-05
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Crystal structures of Mycobacterial MeaB and MMAA-like GTPases. J.Struct.Funct.Genom., 16, 2015

3TSC

Crystal structure of short chain dehydrogenase MAP_2410 from Mycobacterium paratuberculosis bound to NAD
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2011-09-12
公開日	2011-10-05
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors. Sci Rep, 7, 2017

4DQ8

Crystal structure of acetate kinase AckA from Mycobacterium marinum
分子名称:	Acetate kinase
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-02-15
公開日	2012-02-22
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4DXL

Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abscessus, bound to CMP and ATP
分子名称:	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-02-27
公開日	2012-03-07
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4DIE

Crystal structure of a cytidylate kinase CmK from Mycobacterium abscessus bound to cytidine-5'-monophosphate
分子名称:	CYTIDINE-5'-MONOPHOSPHATE, Cytidylate kinase, PHOSPHATE ION
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-01-30
公開日	2012-02-08
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4DI1

Crystal structure of enoyl-CoA hydratase EchA17 from Mycobacterium marinum
分子名称:	1,2-ETHANEDIOL, Enoyl-CoA hydratase EchA17
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-01-30
公開日	2012-02-08
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4EGF

Crystal structure of a L-xylulose reductase from Mycobacterium smegmatis
分子名称:	L-xylulose reductase
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID), Arakaki, T.L, Staker, B.L, Fairman, J.W.
登録日	2012-03-30
公開日	2012-05-02
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4ED4

Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to ATP
分子名称:	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-03-26
公開日	2012-04-04
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4EO9

Crystal structure of a phosphoglycerate mutase gpm1 from Mycobacterium leprae
分子名称:	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, CHLORIDE ION
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-04-13
公開日	2012-04-25
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.45 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4EYE

Crystal structure of a probable oxidoreductase from Mycobacterium abscessus solved by iodide ion SAD
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Probable oxidoreductase
著者	Edwards, T.E, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-05-01
公開日	2012-05-09
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4E98

Crystal structure of possible CutA1 divalent ion tolerance protein from Cryptosporidium parvum Iowa II
分子名称:	CHLORIDE ION, CutA1 divalent ion tolerance protein
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID), Buchko, G.W, Robinson, H.
登録日	2012-03-20
公開日	2012-04-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis. Acta Crystallogr F Struct Biol Commun, 71, 2015

4EMD

Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to CMP and SO4
分子名称:	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CYTIDINE-5'-MONOPHOSPHATE, SULFATE ION
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-04-11
公開日	2012-04-25
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4EGE

Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans
分子名称:	1,2-ETHANEDIOL, Dipeptidase PepE, UNKNOWN ATOM OR ION, ...
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2012-03-30
公開日	2012-04-25
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

6BFA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1553
分子名称:	1-{4-amino-3-[6-(cyclopropyloxy)naphthalen-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2017-10-26
公開日	2017-12-06
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016

4Y5Q

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP
分子名称:	ADENOSINE MONOPHOSPHATE, CALCIUM ION, Calmodulin-domain protein kinase 1, ...
著者	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2015-02-11
公開日	2015-02-25
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP To Be Published

4ONA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
分子名称:	5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-01-28
公開日	2014-03-19
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

3LAA

Crystal structure of the trimeric autotransporter adhesin head domain BpaA from Burkholderia pseudomallei
分子名称:	Haemagglutinin family protein
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2010-01-06
公開日	2010-05-12
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.35 Å)
主引用文献	Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head. Plos One, 5, 2010

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