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Crystal structure of ITK in complex with compound 9 [4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1H-pyrazole-3-carboxamide] and ADP
分子名称:	4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1H-pyrazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Tyrosine-protein kinase ITK/TSK
著者	Han, S, Caspers, N.L.
登録日	2013-08-02
公開日	2014-04-02
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.52 Å)
主引用文献	Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors. Biochem.J., 460, 2014

SF3b core in complex with a splicing modulator
分子名称:	PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ...
著者	Cretu, C, Pena, V.
登録日	2017-10-04
公開日	2018-06-20
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (3.08 Å)
主引用文献	Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds. Mol. Cell, 70, 2018

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1
分子名称:	1,2-ETHANEDIOL, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide, Bromodomain-containing protein 4, ...
著者	Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Fish, P, Bunnage, M, Owen, D, Knapp, S, Cook, A, Structural Genomics Consortium (SGC)
登録日	2012-03-20
公開日	2012-04-18
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.92 Å)
主引用文献	Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J.Med.Chem., 55, 2012