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PfCopC mutant - D83N
分子名称:	ACETATE ION, CHLORIDE ION, COPPER (II) ION, ...
著者	Muderspach, S.J, Ipsen, J, Rollan, C.H, Bertelsen, A.B, Norholm, M.H.H, Johansen, K.S, Lo Leggio, L.
登録日	2021-01-15
公開日	2021-07-07
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC. Febs Lett., 595, 2021

X-ray structure of SCoV2-PLpro in complex with small molecule inhibitor
分子名称:	1,2-ETHANEDIOL, Non-structural protein 3, PROFLAVIN, ...
著者	Napolitano, V, Mourao, A, Bostock, M, Matsuda, A, Czarna, A, Popowicz, G.M.
登録日	2021-03-09
公開日	2022-02-02
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.68 Å)
主引用文献	Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chem Biol, 29, 2022

Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST
分子名称:	Mast/stem cell growth factor receptor Kit, ~{N}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine
著者	Graedler, U, Lammens, A.
登録日	2022-05-19
公開日	2023-02-22
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.119 Å)
主引用文献	Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors. J.Med.Chem., 66, 2023

Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST
分子名称:	5-imidazo[1,2-a]pyridin-3-yl-~{N}-[(1~{R})-1-(6-pyrrolidin-1-ylpyridin-3-yl)ethyl]pyridin-3-amine, HUMAN PROTO-ONCOGENE C-KIT
著者	Graedler, U, Lammens, A.
登録日	2022-05-24
公開日	2023-02-22
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (3.09 Å)
主引用文献	Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors. J.Med.Chem., 66, 2023