8UP9
 
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19Q) | | 分子名称: | 1,2-ETHANEDIOL, Asparaginase, CHLORIDE ION, ... | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-21 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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2YBU
 | | Crystal structure of human acidic chitinase in complex with bisdionin F | | 分子名称: | 3,7-DIMETHYL-1-[3-(3-METHYL-2,6-DIOXO-9H-PURIN-1-YL)PROPYL]PURINE-2,6-DIONE, ACIDIC MAMMALIAN CHITINASE, GLYCEROL | | 著者 | Sutherland, T.E, Andersen, O.A, Betou, M, Eggleston, I.M, Maizels, R.M, van Aalten, D, Allen, J.E. | | 登録日 | 2011-03-10 | | 公開日 | 2011-06-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Chem. Biol., 18, 2011
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8UOR
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19E) | | 分子名称: | 1,2-ETHANEDIOL, Asparaginase, CHLORIDE ION | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-20 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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8UP8
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant Y21F, complex with L-Asp) | | 分子名称: | ASPARTIC ACID, Asparaginase, CHLORIDE ION, ... | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-21 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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2VTP
 | | Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design. | | 分子名称: | CELL DIVISION PROTEIN KINASE 2, {[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide | | 著者 | Wyatt, P.G, Woodhead, A.J, Boulstridge, J.A, Berdini, V, Carr, M.G, Cross, D.M, Danillon, D, Davis, D.J, Devine, L.A, Early, T.R, Feltell, R.E, Lewis, E.J, McMenamin, R.L, Navarro, E.F, O'Brien, M.A, O'Reilly, M, Reule, M, Saxty, G, Seavers, L.C.A, Smith, D, Squires, M.S, Trewartha, G, Walker, M.T, Woolford, A.J. | | 登録日 | 2008-05-15 | | 公開日 | 2008-08-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H-Pyrazole-3-Carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
J.Med.Chem., 51, 2008
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2VTH
 | | Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design | | 分子名称: | 5-hydroxynaphthalene-1-sulfonamide, CELL DIVISION PROTEIN KINASE 2, GLYCEROL | | 著者 | Wyatt, P.G, Woodhead, A.J, Boulstridge, J.A, Berdini, V, Carr, M.G, Cross, D.M, Danillon, D, Davis, D.J, Devine, L.A, Early, T.R, Feltell, R.E, Lewis, E.J, McMenamin, R.L, Navarro, E.F, O'Brien, M.A, O'Reilly, M, Reule, M, Saxty, G, Seavers, L.C.A, Smith, D, Squires, M.S, Trewartha, G, Walker, M.T, Woolford, A.J. | | 登録日 | 2008-05-15 | | 公開日 | 2008-08-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H-Pyrazole-3-Carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
J.Med.Chem., 51, 2008
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2E2J
 | | RNA polymerase II elongation complex in 5 mM Mg+2 with GMPCPP | | 分子名称: | 27-MER DNA template strand, 5'-D(P*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*A)-3', 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-14 | | 公開日 | 2006-12-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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7ZL8
 | | NME1 in complex with succinyl-CoA | | 分子名称: | Nucleoside diphosphate kinase A, SUCCINYL-COENZYME A | | 著者 | Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. | | 登録日 | 2022-04-14 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.
Sci Adv, 9, 2023
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2EB4
 | | Crystal structure of apo-HpcG | | 分子名称: | 2-oxo-hept-3-ene-1,7-dioate hydratase, SODIUM ION, THIOCYANATE ION | | 著者 | Izumi, A, Rea, D, Adachi, T, Unzai, S, Park, S.Y, Roper, D.I, Tame, J.R.H. | | 登録日 | 2007-02-07 | | 公開日 | 2007-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli
J.Mol.Biol., 370, 2007
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7ZLW
 | | NME1 in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | | 著者 | Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. | | 登録日 | 2022-04-15 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.
Sci Adv, 9, 2023
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8UOU
 | | Structure of atypical asparaginase from Rhodospirillum rubrum in complex with L-Asp | | 分子名称: | ASPARTIC ACID, Asparaginase, CHLORIDE ION | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-20 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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7ZTK
 | | NME1 in complex with CoA | | 分子名称: | COENZYME A, Nucleoside diphosphate kinase A | | 著者 | Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. | | 登録日 | 2022-05-10 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.
Sci Adv, 9, 2023
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2YEV
 | | Structure of caa3-type cytochrome oxidase | | 分子名称: | (1R,4S,6R)-6-({[2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL]OXY}METHYL)-4-HYDROXY-1-{[(15-METHYLHEXADECANOYL)OXY]METHYL}-4-OXIDO-7-OXO-3,5-DIOXA-8-AZA-4-PHOSPHAHEPTACOS-1-YL 15-METHYLHEXADECANOATE, (2R)-2,3-DIHYDROXYPROPYL (7Z)-TETRADEC-7-ENOATE, (2R)-3-HYDROXYPROPANE-1,2-DIYL DIHEXADECANOATE, ... | | 著者 | Lyons, J.A, Aragao, D, Soulimane, T, Caffrey, M. | | 登録日 | 2011-03-31 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Structural Insights Into Electron Transfer in Caa3-Type Cytochrome Oxidases.
Nature, 487, 2012
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2Y6N
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8UTA
 | | yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N | | 分子名称: | Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, MAGNESIUM ION, ... | | 著者 | Krochmal, D, Lewicka, A, Piccirilli, J.A. | | 登録日 | 2023-10-30 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
Cell Discov, 10, 2024
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8UOW
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant Y21A) | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Asparaginase | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-20 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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2YMD
 | | Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with serotonin (5-hydroxytryptamine) | | 分子名称: | GLYCEROL, PHOSPHATE ION, SEROTONIN, ... | | 著者 | Kesters, D, Thompson, A.J, Brams, M, Elk, R.v, Spurny, R, Geitmann, M, Villalgordo, J.M, Guskov, A, Danielson, U.H, Lummis, S.C.R, Smit, A.B, Ulens, C. | | 登録日 | 2012-10-09 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural Basis of Ligand Recognition in 5-Ht(3) Receptors.
Embo Rep., 14, 2013
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2Y7Y
 | | APLYSIA CALIFORNICA ACHBP IN APO STATE | | 分子名称: | SOLUBLE ACETYLCHOLINE RECEPTOR | | 著者 | Ulens, C, Akdemir, A, Jongejan, A, van Elk, R, Bertrand, S, Perrakis, A, Leurs, R, Smit, A.B, Sixma, T.K, Bertrand, D, De Esch, I.J. | | 登録日 | 2011-02-02 | | 公開日 | 2011-03-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.895 Å) | | 主引用文献 | Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-Ray Analysis.
J.Med.Chem., 52, 2009
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2YAZ
 | | The Crystal Structure of Leishmania major dUTPase in complex dUMP | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DUTPASE, MAGNESIUM ION, ... | | 著者 | Hemsworth, G.R, Moroz, O.V, Fogg, M.J, Scott, B, Bosch-Navarrete, C, Gonzalez-Pacanowska, D, Wilson, K.S. | | 登録日 | 2011-02-25 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
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8UIW
 | | yjdF riboswitch from R. gauvreauii in complex with chelerythrine bound to Fab BL3-6 S97N | | 分子名称: | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, ... | | 著者 | Krochmal, D, Lewicka, A, Piccirilli, J.A. | | 登録日 | 2023-10-10 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
Cell Discov, 10, 2024
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2YAY
 | | The Crystal Structure of Leishmania major dUTPase in complex with substrate analogue dUpNpp | | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DUTPASE | | 著者 | Hemsworth, G.R, Moroz, O.V, Fogg, M.J, Scott, B, Bosch-Navarrete, C, Gonzalez-Pacanowska, D, Wilson, K.S. | | 登録日 | 2011-02-25 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
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8UKQ
 | | RNA polymerase II elongation complex with Fapy-dG lesion in apo state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Hou, P, Oh, J, Wang, D. | | 登録日 | 2023-10-15 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
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8UKT
 | | RNA polymerase II elongation complex with Fapy-dG lesion with AMP added | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Hou, P, Oh, J, Wang, D. | | 登録日 | 2023-10-15 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
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8UKU
 | | RNA polymerase II elongation complex with Fapy-dG lesion with CMP added | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Hou, P, Oh, J, Wang, D. | | 登録日 | 2023-10-15 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
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8UKS
 | | RNA polymerase II elongation complex with Fapy-dG lesion soaking with CTP before chemistry | | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Hou, P, Oh, J, Wang, D. | | 登録日 | 2023-10-15 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
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