4NJU
 
 | | Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with tipranavir | | 分子名称: | N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, Protease | | 著者 | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Mitsuya, H. | | 登録日 | 2013-11-11 | | 公開日 | 2014-04-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
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4NJT
 | | Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir | | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | | 著者 | Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | | 登録日 | 2013-11-11 | | 公開日 | 2014-04-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
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4NJS
 | | Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL008 | | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-carbamoylphenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, Protease | | 著者 | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | | 登録日 | 2013-11-11 | | 公開日 | 2014-04-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
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1QBZ
 | | THE CRYSTAL STRUCTURE OF THE SIV GP41 ECTODOMAIN AT 1.47 A | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, MERCURY (II) ION, ... | | 著者 | Yang, Z.-N, Mueser, T.C, Kaufman, J, Stahl, S.J, Wingfield, P.T, Hyde, C.C. | | 登録日 | 1999-04-28 | | 公開日 | 1999-05-17 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | The crystal structure of the SIV gp41 ectodomain at 1.47 A resolution.
J.Struct.Biol., 126, 1999
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6I1B
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7I1B
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4TRX
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3TRX
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2JR0
 | | Solution structure of NusB from Aquifex Aeolicus | | 分子名称: | N utilization substance protein B homolog | | 著者 | Das, R, Loss, S, Li, J, Tarasov, S, Wingfield, P, Waugh, D.S, Byrd, R.A, Altieri, A.S. | | 登録日 | 2007-06-18 | | 公開日 | 2008-02-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural biophysics of the NusB:NusE antitermination complex.
J.Mol.Biol., 376, 2008
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7U0F
 | | HIV-1 Rev in complex with tubulin | | 分子名称: | Protein Rev, Tubulin alpha-1A chain, Tubulin beta chain | | 著者 | Eren, E. | | 登録日 | 2022-02-18 | | 公開日 | 2023-08-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev.
Structure, 31, 2023
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2EZQ
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2EZR
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2EZP
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2EZS
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2EZO
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8VJN
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8VJO
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1D8V
 | | THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30. | | 分子名称: | ANTI-HIV AND ANTI-TUMOR PROTEIN MAP30 | | 著者 | Wang, Y.-X, Neamati, N, Jacob, J, Palmer, I, Stahl, S.J. | | 登録日 | 1999-10-26 | | 公開日 | 1999-11-19 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions.
Cell(Cambridge,Mass.), 99, 1999
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1QCE
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1QA4
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1QA5
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2NVH
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7M18
 | | HeLa-tubulin in complex with cryptophycin 1 | | 分子名称: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Eren, E. | | 登録日 | 2021-03-12 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action.
J.Biol.Chem., 297, 2021
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7M20
 | | 18-mer HeLa-tubulin rings in complex with Cryptophycin 1 | | 分子名称: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Eren, E. | | 登録日 | 2021-03-15 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action.
J.Biol.Chem., 297, 2021
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7LXB
 | | HeLa-tubulin in complex with cryptophycin 52 | | 分子名称: | Cryptophycin 52, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Eren, E. | | 登録日 | 2021-03-03 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action.
J.Biol.Chem., 297, 2021
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