8FQM
 
 | | ADC-7 in complex with boronic acid transition state inhibitor MB076 | | 分子名称: | 1-[(2R)-2-{2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetamido}-2-boronoethyl]-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, GLYCINE | | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Fernando, M.C. | | 登録日 | 2023-01-06 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J.Med.Chem., 66, 2023
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8FQO
 | | ADC-33 in complex with boronic acid transition state inhibitor MB076 | | 分子名称: | 1-[(2R)-2-{2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetamido}-2-boronoethyl]-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Fish, E.R. | | 登録日 | 2023-01-06 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J.Med.Chem., 66, 2023
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8FQN
 | | apo ADC-33 beta-lactamase | | 分子名称: | Beta-lactamase, GLYCINE, PHOSPHATE ION | | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Fish, E.R. | | 登録日 | 2023-01-06 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.256 Å) | | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J.Med.Chem., 66, 2023
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8FQP
 | | apo ADC-162 beta-lactamase | | 分子名称: | Beta-lactamase, GLYCINE, PHOSPHATE ION | | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Fernando, M.C. | | 登録日 | 2023-01-06 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.419 Å) | | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J.Med.Chem., 66, 2023
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6PWL
 | | ADC-7 in complex with boronic acid transition state inhibitor LP06 | | 分子名称: | (7Z)-7-(2-amino-1,3-thiazol-4-yl)-1,1,3-trihydroxy-10,10-dimethyl-1,6-dioxo-2,9-dioxa-5,8-diaza-1lambda~5~-phospha-3-boraundec-7-en-11-oic acid, Beta-lactamase, GLYCINE | | 著者 | Curtis, B.C, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-07-23 | | 公開日 | 2020-10-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.
Antimicrob.Agents Chemother., 64, 2020
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6PWM
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5W14
 | | ADC-7 in complex with boronic acid transition state inhibitor S03043 | | 分子名称: | 3-{1-[(2R)-2-borono-2-{[(thiophen-2-yl)acetyl]amino}ethyl]-1H-1,2,3-triazol-4-yl}benzoic acid, Beta-lactamase | | 著者 | Smolen, K.A, Powers, R.A, Wallar, B.J. | | 登録日 | 2017-06-01 | | 公開日 | 2017-11-29 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel beta-Lactamase Inhibitors.
ACS Infect Dis, 4, 2018
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5W12
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5W13
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6TZH
 | | ADC-7 in complex with boronic acid transition state inhibitor S06015 | | 分子名称: | Beta-lactamase, GLYCINE, PHOSPHATE ION, ... | | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-08-12 | | 公開日 | 2020-06-24 | | 最終更新日 | 2020-07-22 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase.
Acs Infect Dis., 6, 2020
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6TZJ
 | | ADC-7 in complex with boronic acid transition state inhibitor ME_096 | | 分子名称: | Beta-lactamase, GLYCINE, [4-[[(4-methylphenyl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]methyl-phosphonooxy-borinic acid | | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-08-12 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase.
Acs Infect Dis., 6, 2020
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6TZI
 | | ADC-7 in complex with boronic acid transition state inhibitor PFC_001 | | 分子名称: | Beta-lactamase, phosphonooxy-[[4-[[2,2,2-tris(fluoranyl)ethylsulfonylamino]methyl]-1,2,3-triazol-1-yl]methyl]borinic acid | | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-08-12 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.744 Å) | | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase.
Acs Infect Dis., 6, 2020
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6TZF
 | | ADC-7 in complex with boronic acid transition state inhibitor S17079 | | 分子名称: | 3-(1-{[hydroxy(phosphonooxy)boranyl]methyl}-1H-1,2,3-triazol-4-yl)benzoic acid, Beta-lactamase | | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-08-12 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase.
Acs Infect Dis., 6, 2020
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6TZG
 | | ADC-7 in complex with boronic acid transition state inhibitor S17083 | | 分子名称: | Beta-lactamase, [4-(3-aminocarbonylphenyl)-1,2,3-triazol-1-yl]methyl-phosphonooxy-borinic acid | | 著者 | Fish, E.R, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-08-12 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.816 Å) | | 主引用文献 | 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase.
Acs Infect Dis., 6, 2020
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1MHZ
 | | METHANE MONOOXYGENASE HYDROXYLASE | | 分子名称: | FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE | | 著者 | Elango, N, Radhakrishnan, R, Froland, W.A, Waller, B.J, Earhart, C.A, Lipscomb, J.D, Ohlendorf, D.H. | | 登録日 | 1996-10-21 | | 公開日 | 1997-05-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b
Protein Sci., 6, 1997
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1MHY
 | | METHANE MONOOXYGENASE HYDROXYLASE | | 分子名称: | FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE | | 著者 | Elango, N, Radhakrishnan, R, Froland, W.A, Waller, B.J, Earhart, C.A, Lipscomb, J.D, Ohlendorf, D.H. | | 登録日 | 1996-10-21 | | 公開日 | 1997-05-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b
Protein Sci., 6, 1997
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