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6UQO
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BU of 6uqo by Molmil
ClpA/ClpP Engaged State bound to RepA-GFP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp endopeptidase proteolytic subunit ClpP, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
著者Lopez, K.L, Rizo, A.N, Southworth, D.R.
登録日2019-10-21
公開日2020-04-22
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6D00
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BU of 6d00 by Molmil
Calcarisporiella thermophila Hsp104
分子名称: ADENOSINE-5'-DIPHOSPHATE, Calcarisporiella thermophila Hsp104
著者Zhang, K, Pintilie, G.
登録日2018-04-09
公開日2019-04-03
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure, 27, 2019
7ZJ2
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BU of 7zj2 by Molmil
Amyloid fibril (in vitro) from full-length hnRNPA1 protein
分子名称: Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1
著者Sharma, K, Banerjee, S, Schmidt, M, Faendrich, M.
登録日2022-04-08
公開日2023-08-02
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Cryo-EM Structure of the Full-length hnRNPA1 Amyloid Fibril.
J.Mol.Biol., 435, 2023
6VUB
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BU of 6vub by Molmil
Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 5 (1-methyl-4-phenylpyrrolidin-2-one)
分子名称: (4R)-1-methyl-4-phenylpyrrolidin-2-one, Bromodomain-containing protein 4
著者Ilyichova, O.V, Scanlon, M.J, Thompson, P.E.
登録日2020-02-14
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.
Eur.J.Med.Chem., 191, 2020
6VUF
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BU of 6vuf by Molmil
Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 7h (4-(1-methyl-5-oxopyrrolidin-3-yl)-N-propylbenzenesulfonamide)
分子名称: 4-[(3R)-1-methyl-5-oxopyrrolidin-3-yl]-N-propylbenzene-1-sulfonamide, Bromodomain-containing protein 4
著者Ilyichova, O.V, Scanlon, M.J, Thompson, P.E.
登録日2020-02-15
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.
Eur.J.Med.Chem., 191, 2020
6VUJ
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BU of 6vuj by Molmil
Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 15c (N,N-diethyl-3',4'-dimethoxy-6-(1-methyl-5-oxopyrrolidin-3-yl)-[1,1'-biphenyl]-3-sulfonamide)
分子名称: Bromodomain-containing protein 4, N,N-diethyl-3',4'-dimethoxy-6-[(3S)-1-methyl-5-oxopyrrolidin-3-yl][1,1'-biphenyl]-3-sulfonamide, NITRATE ION
著者Ilyichova, O.V, Scanlon, M.J, Thompson, P.E.
登録日2020-02-15
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.
Eur.J.Med.Chem., 191, 2020
6VUC
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BU of 6vuc by Molmil
Crystal structure of BRD4 bromodomain 1 with N-methylpyrrolidin-2-one (NMP) derivative 7b (1-methyl-4-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-one)
分子名称: (4R)-1-methyl-4-{4-[(piperidin-1-yl)sulfonyl]phenyl}pyrrolidin-2-one, Bromodomain-containing protein 4
著者Ilyichova, O.V, Scanlon, M.J, Thompson, P.E.
登録日2020-02-14
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.
Eur.J.Med.Chem., 191, 2020
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