6TD5
| Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib | 分子名称: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome endopeptidase complex, Proteasome subunit alpha type, ... | 著者 | Srinivas, H. | 登録日 | 2019-11-07 | 公開日 | 2020-08-26 | 最終更新日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem., 63, 2020
|
|
6TCZ
| Leishmania tarentolae proteasome 20S subunit complexed with LXE408 | 分子名称: | Proteasome endopeptidase complex, Proteasome subunit alpha type, Proteasome subunit beta, ... | 著者 | Srinivas, H. | 登録日 | 2019-11-07 | 公開日 | 2020-08-26 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem., 63, 2020
|
|
3LJ1
| IRE1 complexed with Cdk1/2 Inhibitor III | 分子名称: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Lee, K.P.K, Sicheri, F. | 登録日 | 2010-01-25 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
|
|
3LJ2
| IRE1 complexed with JAK Inhibitor I | 分子名称: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Lee, K.P.K, Sicheri, F. | 登録日 | 2010-01-25 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
|
|
3LJ0
| IRE1 complexed with ADP and Quercetin | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Lee, K.P.K, Sicheri, F. | 登録日 | 2010-01-25 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
|
|