6FV5
| QTRT2, the non-catalytic subunit of murine tRNA-Guanine Transglycosylase | 分子名称: | DI(HYDROXYETHYL)ETHER, MALONATE ION, Queuine tRNA-ribosyltransferase accessory subunit 2, ... | 著者 | Behrens, C, Heine, A, Reuter, K. | 登録日 | 2018-03-01 | 公開日 | 2018-06-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.179 Å) | 主引用文献 | Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase. Biochemistry, 57, 2018
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6H62
| QTRT1, the catalytic subunit of murine tRNA-Guanine Transglycosylase | 分子名称: | GLYCEROL, Queuine tRNA-ribosyltransferase catalytic subunit 1, ZINC ION | 著者 | Behrens, C, Heine, A, Reuter, K. | 登録日 | 2018-07-26 | 公開日 | 2019-08-14 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (2.684 Å) | 主引用文献 | Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Acs Chem.Biol., 17, 2022
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4GCX
| tRNA-guanine transglycosylase Y106F, C158V, V233G mutant in complex with preQ1 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Schmidt, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-07-31 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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4GD0
| tRNA-guanine transglycosylase Y106F, C158V mutant | 分子名称: | GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Schmidt, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-07-31 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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4H7Z
| tRNA-guanine transglycosylase Y106F, C158V mutant in complex with guanine | 分子名称: | GLYCEROL, GUANINE, Queuine tRNA-ribosyltransferase, ... | 著者 | Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-09-21 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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4H6E
| tRNA-guanine transglycosylase Y106F, C158V, V233G mutant apo structure | 分子名称: | GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-09-19 | 公開日 | 2012-11-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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4HSH
| tRNA-guanine transglycosylase Y106F, V233G mutant in complex with queuine | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-10-30 | 公開日 | 2012-11-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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4HVX
| tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-11-07 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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4HQV
| tRNA-guanine transglycosylase Y106F, C158V, V233G mutant in complex with queuine | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2012-10-26 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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2NQZ
| Trna-guanine transglycosylase (TGT) mutant in complex with 7-deaza-7-aminomethyl-guanine | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Tidten, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2006-11-01 | 公開日 | 2007-11-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor Plos One, 8, 2013
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2POT
| tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine | 分子名称: | GLYCEROL, GUANINE, Queuine tRNA-ribosyltransferase, ... | 著者 | Tidten, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2007-04-27 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies. J.Mol.Biol., 374, 2007
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2PWU
| tRNA guanine transglycosylase in complex with guanine | 分子名称: | GLYCEROL, GUANINE, Queuine tRNA-ribosyltransferase, ... | 著者 | Tidten, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2007-05-13 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies. J.Mol.Biol., 374, 2007
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2PWV
| tRNA guanine transglycosylase E235Q mutant in complex with preQ0 | 分子名称: | 2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Tidten, N, Stengl, B, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2007-05-13 | 公開日 | 2007-10-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies. J.Mol.Biol., 374, 2007
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2NSO
| Trna-gunanine-transglycosylase (TGT) mutant Y106F, C158V, A232S, V233G- APO-Structure | 分子名称: | GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Tidten, N, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2006-11-06 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor. Plos One, 8, 2013
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2QII
| Crystal Structure Of tRNA-Guanine Transglycosylase (TGT) From Zymomonas mobilis Complexed With Archaeosine Precursor, Preq0 | 分子名称: | 2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Tidten, N, Brenk, R, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2007-07-04 | 公開日 | 2007-07-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies. J.Mol.Biol., 374, 2007
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1ENU
| A new target for shigellosis: Rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase | 分子名称: | 4-AMINOPHTHALHYDRAZIDE, TRNA-GUANINE TRANSGLYCOSYLASE, ZINC ION | 著者 | Gradler, U, Gerber, H.D, Goodenough-Lashua, D.M, Garcia, G.A, Ficner, R, Reuter, K, Stubbs, M.T, Klebe, G. | 登録日 | 2000-03-21 | 公開日 | 2000-04-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. J.Mol.Biol., 306, 2001
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7B2I
| Heterodimeric tRNA-Guanine Transglycosylase from mouse | 分子名称: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, ... | 著者 | Sebastiani, M, Heine, A, Reuter, K. | 登録日 | 2020-11-27 | 公開日 | 2021-12-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Acs Chem.Biol., 17, 2022
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1P0D
| CRYSTAL STRUCTURE OF ZYMOMONAS MOBILIS tRNA-GUANINE TRANSGLYCOSYLASE (TGT) CRYSTALLISED AT PH 5.5 | 分子名称: | Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-10 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme
tRNA-guanine transglycosylase and their implications for substrate selectivity,
reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1P0B
| Crystal Structure Of tRNA-Guanine Transglycosylase (TGT) From Zymomonas mobilis Complexed With Archaeosine Precursor, Preq0 | 分子名称: | 2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-10 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase
and their implications for substrate selectivity, reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1OZQ
| CRYSTAL STRUCTURE OF THE MUTATED TRNA-GUANINE TRANSGLYCOSYLASE (TGT)Y106F COMPLEXED WITH PREQ1 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-09 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase
and their implications for substrate selectivity, reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1OZM
| Y106F mutant of Z. mobilis TGT | 分子名称: | Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-09 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme
tRNA-guanine transglycosylase and their implications for substrate selectivity,
reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1P0E
| CRYSTAL STRUCTURE OF ZYMOMONAS MOBILIS tRNA-GUANINE TRANSGLYCOSYLASE (TGT) COCRYSTALLISED WITH PREQ1 AT PH 5.5 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-10 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase
and their implications for substrate selectivity, reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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2Z1X
| tRNA guanine transglycosylase E235Q mutant in complex with preQ1 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Tidten, N, Stengl, B, Heine, A, Garcia, G.A, Klebe, G, Reuter, K. | 登録日 | 2007-05-16 | 公開日 | 2007-11-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies J.Mol.Biol., 374, 2007
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1PXG
| Crystal structure of the mutated tRNA-guanine transglycosylase (TGT) D280E complexed with preQ1 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Kittendorf, J.D, Sgraja, T, Reuter, K, Klebe, G, Garcia, G.A. | 登録日 | 2003-07-04 | 公開日 | 2003-09-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coli. J.Biol.Chem., 278, 2003
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1Q4W
| CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE | 分子名称: | 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Meyer, E, Reuter, K, Stubbs, M.T, Garcia, G.A, Klebe, G. | 登録日 | 2003-08-04 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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