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E. coli 50S ribosome bound to compound 47
分子名称:	(3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ...
著者	Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
登録日	2019-06-16
公開日	2020-06-17
最終更新日	2020-10-07
実験手法	ELECTRON MICROSCOPY (2.5 Å)
主引用文献	Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020

Crystal structure of Syk in complex with GS-9876
分子名称:	6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine, Tyrosine-protein kinase SYK
著者	Lansdon, E.B.
登録日	2020-01-31
公開日	2020-03-11
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases. Acs Med.Chem.Lett., 11, 2020