3L3A
| Bace-1 with the aminopyridine Compound 32 | 分子名称: | 4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorophenyl)-1H-pyrrol-2-yl}phenoxy)butanenitrile, Beta-secretase 1 | 著者 | Olland, A.M, Chopra, R. | 登録日 | 2009-12-16 | 公開日 | 2010-04-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.362 Å) | 主引用文献 | Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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2ZE1
| X-ray structure of Bace-1 in complex with compound 6g | 分子名称: | 3-bromo-N-[4-[1-(2-carbamimidamido-2-oxo-ethyl)-5-phenyl-pyrrol-2-yl]phenyl]benzamide, Beta-secretase 1 | 著者 | Chopra, R, Olland, A. | 登録日 | 2007-12-05 | 公開日 | 2008-12-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets. Bioorg.Med.Chem.Lett., 18, 2008
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2ZDZ
| X-ray structure of Bace-1 in complex with compound 3.b.10 | 分子名称: | Beta-secretase 1, N-carbamimidoyl-2-[2-(2-chlorophenyl)-5-[4-(4-ethanoylphenoxy)phenyl]pyrrol-1-yl]ethanamide | 著者 | Chopra, R, Olland, A. | 登録日 | 2007-12-04 | 公開日 | 2008-12-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets. Bioorg.Med.Chem.Lett., 18, 2008
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2QU3
| BACE1 with Compound 2 | 分子名称: | Beta-secretase 1, N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide | 著者 | Chopra, R. | 登録日 | 2007-08-03 | 公開日 | 2008-08-05 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Thiophene substituted acylguanidines as BACE1 inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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2QU2
| BACE1 with Compound 1 | 分子名称: | Beta-secretase 1, N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide | 著者 | Chopra, R. | 登録日 | 2007-08-03 | 公開日 | 2008-08-05 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Thiophene substituted acylguanidines as BACE1 inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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3LHG
| Bace1 in complex with the aminohydantoin Compound 4g | 分子名称: | (5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-methyl-5-pyridin-4-yl-3,5-dihydro-4H-imidazol-4-one, Beta-secretase 1 | 著者 | Olland, A.M. | 登録日 | 2010-01-22 | 公開日 | 2010-04-21 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Pyridinyl aminohydantoins as small molecule BACE1 inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3LXG
| Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3 | 分子名称: | 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine, MAGNESIUM ION, ZINC ION, ... | 著者 | Mosbacher, T, Jestel, A, Steinbacher, S. | 登録日 | 2010-02-25 | 公開日 | 2010-05-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J.Med.Chem., 53, 2010
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