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1B3S
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BU of 1b3s by Molmil
STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称: PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日1998-12-01
公開日1998-12-09
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structural response to mutation at a protein-protein interface.
J.Mol.Biol., 286, 1999
1BAO
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BU of 1bao by Molmil
THE CONTRIBUTION OF BURIED HYDROGEN BONDS TO PROTEIN STABILITY: THE CRYSTAL STRUCTURES OF TWO BARNASE MUTANTS
分子名称: BARNASE, ZINC ION
著者Chen, Y.W, Fersht, A.R, Henrick, K.
登録日1993-05-19
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants.
J.Mol.Biol., 234, 1993
1B2U
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BU of 1b2u by Molmil
STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称: PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日1998-12-01
公開日1998-12-09
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural response to mutation at a protein-protein interface.
J.Mol.Biol., 286, 1999
1BRS
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BU of 1brs by Molmil
PROTEIN-PROTEIN RECOGNITION: CRYSTAL STRUCTURAL ANALYSIS OF A BARNASE-BARSTAR COMPLEX AT 2.0-A RESOLUTION
分子名称: BARNASE, BARSTAR
著者Buckle, A.M, Schreiber, G, Fersht, A.R.
登録日1994-03-11
公開日1994-06-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution.
Biochemistry, 33, 1994
1BSE
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BU of 1bse by Molmil
CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
分子名称: BARNASE
著者Buckle, A.M, Henrick, K, Fersht, A.R.
登録日1993-07-19
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1RNB
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BU of 1rnb by Molmil
CRYSTAL STRUCTURE OF A BARNASE-D(*GP*C) COMPLEX AT 1.9 ANGSTROMS RESOLUTION
分子名称: BARNASE, DNA (5'-D(*GP*C)-3'), SULFATE ION
著者Janin, J, Baudet, S.
登録日1991-03-19
公開日1992-07-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a barnase-d(GpC) complex at 1.9 A resolution.
J.Mol.Biol., 219, 1991
1B21
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BU of 1b21 by Molmil
DELETION OF A BURIED SALT BRIDGE IN BARNASE
分子名称: PROTEIN (BARNASE), ZINC ION
著者Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R.
登録日1998-12-03
公開日1998-12-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
1B20
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BU of 1b20 by Molmil
DELETION OF A BURIED SALT-BRIDGE IN BARNASE
分子名称: PROTEIN (BARNASE), ZINC ION
著者Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R.
登録日1998-12-03
公開日1998-12-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
1B2Z
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BU of 1b2z by Molmil
DELETION OF A BURIED SALT BRIDGE IN BARNASE
分子名称: PROTEIN (BARNASE), ZINC ION
著者Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R.
登録日1998-12-03
公開日1998-12-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
1B2X
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BU of 1b2x by Molmil
BARNASE WILDTYPE STRUCTURE AT PH 7.5 FROM A CRYO_COOLED CRYSTAL AT 100K
分子名称: PROTEIN (BARNASE), ZINC ION
著者Harrison, P, Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日1998-12-03
公開日1998-12-09
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
1BNS
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BU of 1bns by Molmil
STRUCTURAL STUDIES OF BARNASE MUTANTS
分子名称: BARNASE
著者Chen, Y.W.
登録日1994-04-11
公開日1994-06-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants.
J.Mol.Biol., 234, 1993
1BSD
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BU of 1bsd by Molmil
CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
分子名称: BARNASE
著者Buckle, A.M, Henrick, K, Fersht, A.R.
登録日1993-07-19
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSB
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BU of 1bsb by Molmil
CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
分子名称: BARNASE
著者Buckle, A.M, Henrick, K, Fersht, A.R.
登録日1993-07-19
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSC
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BU of 1bsc by Molmil
CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
分子名称: BARNASE
著者Buckle, A.M, Henrick, K, Fersht, A.R.
登録日1993-07-19
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BNI
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BU of 1bni by Molmil
BARNASE WILDTYPE STRUCTURE AT PH 6.0
分子名称: BARNASE
著者Cameron, A, Henrick, K, Fersht, A.R, Dodson, G, Buckle, A.M.
登録日1995-05-17
公開日1995-09-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSA
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BU of 1bsa by Molmil
CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
分子名称: BARNASE
著者Buckle, A.M, Henrick, K, Fersht, A.R.
登録日1993-07-19
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BNJ
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BU of 1bnj by Molmil
BARNASE WILDTYPE STRUCTURE AT PH 9.0
分子名称: BARNASE
著者Cameron, A, Henrick, K, Fersht, A.R, Dodson, G, Buckle, A.M.
登録日1995-05-17
公開日1995-09-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BRG
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BU of 1brg by Molmil
CRYSTALLOGRAPHIC ANALYSIS OF PHE->LEU SUBSTITUTION IN THE HYDROPHOBIC CORE OF BARNASE
分子名称: BARNASE, ZINC ION
著者Chen, Y.W, Fersht, A.R, Henrick, K.
登録日1994-03-30
公開日1994-06-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystallographic analysis of Phe-->Leu substitution in the hydrophobic core of barnase.
Acta Crystallogr.,Sect.D, 51, 1995
1BRN
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BU of 1brn by Molmil
SUBSITE BINDING IN AN RNASE: STRUCTURE OF A BARNASE-TETRANUCLEOTIDE COMPLEX AT 1.76 ANGSTROMS RESOLUTION
分子名称: DNA (5'-D(*CP*GP*AP*C)-3'), PROTEIN (BARNASE (E.C.3.1.27.-))
著者Buckle, A.M, Fersht, A.R.
登録日1993-11-17
公開日1994-01-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Subsite binding in an RNase: structure of a barnase-tetranucleotide complex at 1.76-A resolution.
Biochemistry, 33, 1994
7OLX
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BU of 7olx by Molmil
MerTK kinase domain with type 1.5 inhibitor containing a tri-methyl pyrazole group
分子名称: CHLORIDE ION, Tyrosine-protein kinase Mer, ~{N}-[[3-[4-[(dimethylamino)methyl]phenyl]imidazo[1,2-a]pyridin-6-yl]methyl]-~{N}-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine
著者Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Winter-Holt, J.
登録日2021-05-20
公開日2021-09-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
J.Med.Chem., 64, 2021
7OLS
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BU of 7ols by Molmil
MerTK kinase domain with type 1.5 inhibitor containing a di-methyl pyrazole group
分子名称: 5-[4-(1,5-dimethylpyrazol-4-yl)-2-methyl-phenyl]-~{N}-(imidazo[1,2-a]pyridin-6-ylmethyl)-~{N}-methyl-1,3,4-oxadiazol-2-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Winter-Holt, J.
登録日2021-05-20
公開日2021-09-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
J.Med.Chem., 64, 2021
7OLV
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BU of 7olv by Molmil
MerTK kinase domain with type 1.5 inhibitor containing a di-methyl, cyano pyrazole group
分子名称: 4-[4-[5-[imidazo[1,2-a]pyridin-6-ylmethyl(methyl)amino]-1,3,4-oxadiazol-2-yl]-3-methyl-phenyl]-2,5-dimethyl-pyrazole-3-carbonitrile, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Winter-Holt, J.
登録日2021-05-20
公開日2021-09-15
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
J.Med.Chem., 64, 2021
7O70
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BU of 7o70 by Molmil
KRasG12C ligand complex
分子名称: 1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2, CALCIUM ION, GTPase KRas, ...
著者Phillips, C.
登録日2021-04-12
公開日2022-04-20
最終更新日2022-05-25
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022
7O83
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KRasG12C ligand complex
分子名称: 1-[(7S)-11-chloro-12-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,15,17-tetrazatetracyclo[8.7.1.02,7.014,18]octadeca-1(17),10,12,14(18),15-pentaen-5-yl]prop-2-en-1-one, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Phillips, C, Breed, J.
登録日2021-04-14
公開日2022-04-20
最終更新日2022-05-25
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022
7OO7
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KRasG12C ligand complex
分子名称: 1-[(6aS)-3-chloro-2-(5-methyl-1H-indazol-4-yl)-5,6,6a,7,9,10-hexahydro-8H-pyrazino[1',2':5,6][1,5]oxazocino[4,3,2-de]quinazolin-8-yl]-2-propen-1-one, CALCIUM ION, GTPase KRas, ...
著者Phillips, C.
登録日2021-05-26
公開日2022-04-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C .
J.Med.Chem., 65, 2022

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