7PCM
 
 | | BurG (holo) in complex with (Z)-2,3-dihydroxy-6-methyl-hept-2-enoate (13): Biosynthesis of cyclopropanol rings in bacterial toxins | | 分子名称: | (Z)-6-methyl-2,3-bis(oxidanyl)hept-2-enoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, ... | | 著者 | Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C. | | 登録日 | 2021-08-03 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat.Chem., 14, 2022
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7PCN
 | | BurG (holo) in complex with gonyenediol (14), trigonic acid (6) and DMS: Biosynthesis of cyclopropanol rings in bacterial toxins | | 分子名称: | (2R)-2-oxidanyl-2-(1-oxidanylcyclopropyl)ethanoic acid, (METHYLSULFANYL)METHANE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | 著者 | Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C. | | 登録日 | 2021-08-03 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat.Chem., 14, 2022
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7PCT
 | | BurG E232Q mutant (holo) in complex with enol-oxalacetate (15): Biosynthesis of cyclopropanol rings in bacterial toxins | | 分子名称: | (~{Z})-2-oxidanylbut-2-enedioic acid, GLYCEROL, Ketol-acid reductoisomerase, ... | | 著者 | Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C. | | 登録日 | 2021-08-04 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat.Chem., 14, 2022
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5MR6
 | | XiaF from Streptomyces sp. in complex with FADH2 and Glycerol | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, XiaF protein | | 著者 | Kugel, S, Baunach, M, Baer, P, Ishida-Ito, M, Sundaram, S, Xu, Z, Groll, M, Hertweck, C. | | 登録日 | 2016-12-21 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
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5C1J
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7AYY
 | | Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ... | | 著者 | Masuyer, G, Davies, J.R, Stenmark, P. | | 登録日 | 2020-11-13 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
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7AYZ
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7AZ0
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4YUF
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4YUC
 | | Crystal Structure of CorB derivatized with S-(2-acetamidoethyl) 4-methyl-3-oxohexanethioate | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CorB, SODIUM ION | | 著者 | Zocher, G, Vilstrup, J, Stehle, T. | | 登録日 | 2015-03-18 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Structural basis of head to head polyketide fusion by CorB.
Chem Sci, 6, 2015
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4KC5
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5LX7
 | | Cys-Gly dipeptidase GliJ mutant D38N | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dipeptidase, FE (III) ION, ... | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2016-09-20 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5LX0
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5LX1
 | | Cys-Gly dipeptidase GliJ mutant D304A | | 分子名称: | Dipeptidase, FE (III) ION, GLYCEROL | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2016-09-19 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5LX4
 | | Cys-Gly dipeptidase GliJ mutant D38H | | 分子名称: | Dipeptidase, FE (III) ION, GLYCEROL | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2016-09-20 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5LWZ
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5NRU
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5NRX
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5NS2
 | | Cys-Gly dipeptidase GliJ in complex with Co2+ | | 分子名称: | CHLORIDE ION, COBALT (II) ION, Dipeptidase gliJ, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2017-04-25 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5NRT
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5NS1
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5NRZ
 | | Cys-Gly dipeptidase GliJ in complex with Mn2+ | | 分子名称: | CHLORIDE ION, Dipeptidase gliJ, GLYCEROL, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2017-04-25 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5NS5
 | | Cys-Gly dipeptidase GliJ in complex with Cu2+ and Zn2+ | | 分子名称: | CHLORIDE ION, COPPER (II) ION, Dipeptidase gliJ, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2017-04-25 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5NRY
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7NCL
 | | Glutathione-S-transferase GliG mutant E82Q | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Glutathione S-transferase GliG | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2021-01-29 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and Mechanistic Insights into C-S Bond Formation in Gliotoxin.
Angew.Chem.Int.Ed.Engl., 60, 2021
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