5KF4
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6A5Q
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6A5S
| Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif | 分子名称: | 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... | 著者 | Xu, Y, Ren, J.Q, Feng, W. | 登録日 | 2018-06-25 | 公開日 | 2019-02-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
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6TR7
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6TR6
| N-acetylserotonin-Notum complex | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-12-17 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J. Pineal Res., 68, 2020
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6TR5
| Melatonin-Notum complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-12-17 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.509 Å) | 主引用文献 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J. Pineal Res., 68, 2020
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3JB4
| Structure of Ljungan virus: insight into picornavirus packaging | 分子名称: | VP0, VP1, VP3 | 著者 | Zhu, L, Wang, X.X, Ren, J.S, Porta, C, Wenham, H, Ekstrom, J.-O, Panjwani, A, Knowles, N.J, Kotecha, A, Siebert, A, Lindberg, M, Fry, E.E, Rao, Z.H, Tuthill, T.J, Stuart, D.I. | 登録日 | 2015-07-21 | 公開日 | 2015-10-21 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of Ljungan virus provides insight into genome packaging of this picornavirus. Nat Commun, 6, 2015
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1A4V
| ALPHA-LACTALBUMIN | 分子名称: | ALPHA-LACTALBUMIN, CALCIUM ION | 著者 | Chandra, N, Acharya, K.R. | 登録日 | 1998-02-05 | 公開日 | 1999-04-27 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. Biochemistry, 37, 1998
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4LWH
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 | 分子名称: | Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazol-5-yl}cyclopropanecarboxamide | 著者 | Li, J, Shi, F, Xiong, B, He, J. | 登録日 | 2013-07-27 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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4LWG
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4 | 分子名称: | 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone, Heat shock protein HSP 90-alpha | 著者 | Li, J, Shi, F, Xiong, B, He, J. | 登録日 | 2013-07-27 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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4LWE
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2 | 分子名称: | Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide | 著者 | Li, J, Shi, F, Xiong, B, He, J. | 登録日 | 2013-07-27 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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4LWF
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3 | 分子名称: | 4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol, Heat shock protein HSP 90-alpha | 著者 | Li, J, Shi, F, Xiong, B, He, J. | 登録日 | 2013-07-27 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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4LWI
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6 | 分子名称: | Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide | 著者 | Li, J, Shi, F, Xiong, B, He, J. | 登録日 | 2013-07-27 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87, 2014
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5GKA
| cryo-EM structure of human Aichi virus | 分子名称: | Genome polyprotein, capsid protein VP0, capsid protein VP1 | 著者 | Zhu, L, Wang, X.X, Ren, J.S, Tuthill, T.J, Fry, E.E, Rao, Z.H, Stuart, D.I. | 登録日 | 2016-07-04 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of human Aichi virus and implications for receptor binding Nat Microbiol, 1, 2016
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6TFM
| Frizzled8 CRD | 分子名称: | Frizzled-8 | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-11-14 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63, 2020
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6TFB
| Carbamazepine binds Frizzled8 | 分子名称: | Frizzled-8, GLYCEROL, benzo[b][1]benzazepine-11-carboxamide | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2019-11-13 | 公開日 | 2020-02-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. J.Med.Chem., 63, 2020
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6TV4
| CFF-Notum complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CAFFEINE, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-01-08 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Caffeine inhibits Notum activity by binding at the catalytic pocket. Commun Biol, 3, 2020
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6TUZ
| Theophylline-Notum complex | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-01-08 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Caffeine inhibits Notum activity by binding at the catalytic pocket. Commun Biol, 3, 2020
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6KMH
| The crystal structure of CASK/Mint1 complex | 分子名称: | Amyloid-beta A4 precursor protein-binding family A member 1, CHLORIDE ION, IODIDE ION, ... | 著者 | Li, W, Feng, W. | 登録日 | 2019-07-31 | 公開日 | 2020-08-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discov, 6, 2020
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6J72
| Crystal structure of IniA from Mycobacterium smegmatis with GTP bound | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Isoniazid inducible gene protein IniA, L(+)-TARTARIC ACID, ... | 著者 | Wang, M.F, Guo, X.Y, Hu, J.J, Li, J, Rao, Z.H. | 登録日 | 2019-01-16 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun, 10, 2019
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6J73
| Crystal structure of IniA from Mycobacterium smegmatis | 分子名称: | Isoniazid inducible gene protein IniA | 著者 | Wang, M.F, Guo, X.Y, Hu, J.J, Li, J, Rao, Z.H. | 登録日 | 2019-01-16 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.211 Å) | 主引用文献 | Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun, 10, 2019
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6CN8
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5NC7
| ENAH EVH1 in complex with Ac-WPPPPTEDEL-NH2 | 分子名称: | ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization, Protein enabled homolog | 著者 | Barone, M, Roske, Y. | 登録日 | 2017-03-03 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc.Natl.Acad.Sci.USA, 117, 2020
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5NEG
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5NBX
| ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-9]-OH | 分子名称: | ACY-2L5-PRO-PRO-8SN, BROMIDE ION, Protein enabled homolog | 著者 | Barone, M, Roske, Y. | 登録日 | 2017-03-02 | 公開日 | 2018-03-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc.Natl.Acad.Sci.USA, 117, 2020
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