5M4J
 
 | | Crystal Structure of Wild-Type Human Prolidase with GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, PROLINE, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5M4G
 | | Crystal Structure of Wild-Type Human Prolidase with Mn ions | | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5M4L
 | | Crystal Structure of Wild-Type Human Prolidase with Mg ions and LeuPro ligand | | 分子名称: | GLYCEROL, HYDROXIDE ION, LEUCINE, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5MBY
 | | Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Piwowarczyk, R, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5M4Q
 | | Crystal Structure of Wild-Type Human Prolidase with Mn ions and Pro ligand | | 分子名称: | GLYCEROL, HYDROXIDE ION, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Weiss, M.S, Mueller, U, Dobbek, H. | | 登録日 | 2016-10-18 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Substrate specificity and reaction mechanism of human prolidase.
FEBS J., 284, 2017
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5MC1
 | | Crystal Structure of Asp276Asn mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MBZ
 | | Crystal Structure of Ser202Phe mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC5
 | | Crystal Structure of delGlu452 mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC3
 | | Crystal Structure of Glu412Lys mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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5MC4
 | | Crystal Structure of Gly448Arg mutant of Human Prolidase with Mn ions and GlyPro ligand | | 分子名称: | GLYCEROL, GLYCINE, HYDROXIDE ION, ... | | 著者 | Wilk, P, Mueller, U, Dobbek, H, Weiss, M.S. | | 登録日 | 2016-11-09 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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6F5Q
 | | Crystal Structure of KDM4D with GF026 ligand | | 分子名称: | 1,2-ETHANEDIOL, 2-[2-(methylsulfonylamino)ethylamino]pyridine-4-carboxylic acid, CHLORIDE ION, ... | | 著者 | Malecki, P.H, Link, A, Weiss, M.S, Heinemann, U. | | 登録日 | 2017-12-02 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Crystal Structure of KDM4D with GF026 ligand
To be published
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6ETG
 | | Crystal structure of KDM4D with tetrazolhydrazide compound 6 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Link, A, Weiss, M.S, Heinemann, U. | | 登録日 | 2017-10-26 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.279 Å) | | 主引用文献 | Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases.
Chemmedchem, 14, 2019
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6F5T
 | | Crystal Structure of KDM4D with tetrazole ligand GF057 | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Link, A, Weiss, M.S, Heinemann, U. | | 登録日 | 2017-12-02 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazole ligand
To be published
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6G9E
 | | Crystal structure of immunomodulatory active chitinase from Trichuris suis - TsES1 - 6 molecules in ASU | | 分子名称: | 1,2-ETHANEDIOL, Immunomodulatory active chitinase | | 著者 | Malecki, P.H, Balster, K, Hartmann, S, Weiss, M.S, Heinemann, U. | | 登録日 | 2018-04-10 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.
J Immunol Res, 2021, 2021
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6G5W
 | | Crystal Structure of KDM4A with compound YP-03-038 | | 分子名称: | (4~{R})-5-methyl-4-phenyl-2-pyridin-2-yl-pyrazolidin-3-one, 1,2-ETHANEDIOL, CITRIC ACID, ... | | 著者 | Malecki, P.H, Carter, D.M, Gohlke, U, Specker, E, Nazare, M, Weiss, M.S, Heinemann, U. | | 登録日 | 2018-03-30 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.
J.Med.Chem., 64, 2021
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6G9C
 | | Crystal structure of immunomodulatory active chitinase from Trichuris suis, TsES1 | | 分子名称: | 1,2-ETHANEDIOL, Immunomodulatory active chitinase | | 著者 | Malecki, P.H, Balster, K, Hartmann, S, Weiss, M.S, Heinemann, U. | | 登録日 | 2018-04-10 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.
J Immunol Res, 2021, 2021
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6G5X
 | | Crystal Structure of KDM4A with compound YP-02-145 | | 分子名称: | 1,2-ETHANEDIOL, 2-(3-methyl-5-oxidanylidene-4-phenyl-4~{H}-pyrazol-1-yl)-3~{H}-benzimidazole-5-carboxylic acid, CITRIC ACID, ... | | 著者 | Malecki, P.H, Carter, D.M, Gohlke, U, Specker, E, Nazare, M, Weiss, M.S, Heinemann, U. | | 登録日 | 2018-03-30 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.
J.Med.Chem., 64, 2021
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6H10
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073 | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.104 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073
To be published
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6GKO
 | | Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, ... | | 著者 | Maj, P, Wilk, P, Jarmula, A, Weiss, M.S, Rode, W. | | 登録日 | 2018-05-21 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.839 Å) | | 主引用文献 | Thymidylate synthase fragment screening
To Be Published
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6H0Y
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022 | | 分子名称: | (2~{R})-3-(4-methoxyphenyl)-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide, 1,2-ETHANEDIOL, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.212 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS022
To be published
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6GYJ
 | | Mouse thymidylate synthase crystal soaked in phenolphthalein | | 分子名称: | 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, SULFATE ION, ... | | 著者 | Maj, P, Jarmula, A, Wilk, P, Weiss, M.S, Rode, W. | | 登録日 | 2018-06-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Thymidylate synthase fragment screening
To be published
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6H0Z
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067
To be published
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6H0X
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA040
To be published
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6H2P
 | | Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and Cacodylate ligand | | 分子名称: | CACODYLATE ION, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Wilk, P, Piwowarczyk, R, Weiss, M.S. | | 登録日 | 2018-07-14 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.479 Å) | | 主引用文献 | Structural basis for prolidase deficiency disease mechanisms.
FEBS J., 285, 2018
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6H11
 | | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA028 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... | | 著者 | Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. | | 登録日 | 2018-07-10 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.516 Å) | | 主引用文献 | Crystal Structure of KDM4D with tetrazolylhydrazide ligand AA028
To be published
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